Method for synthesizing tocopherol succinate

Abstract

The invention discloses a method for synthesizing tocopherol succinate. The method comprises the following steps: by taking tocopherol and succinic acid as raw materials and taking lipase as a catalyst, adding the tocopherol and succinic acid in a mole ratio of (1: 1) to (1: 5) into a double-solvent reaction mixed solvent which is prepared by mixing a halohydrocarbon or alkane solvent and DMSO; reacting at 20-60 DEG C for 24-48h by using a method of generating water through an azeotropic removal reaction system while reacting; cooling to room temperature; washing to be neutral by diluted hydrochloric acid and pure water after the reaction is finished; standing for layering to separate out the lower water phase; removing the solvent of the oil phase under vacuum state; adding normal hexane to crystallize; and drying and grinding to obtain high-purity natural vitamin E monoester succinate.

Description

technical field

[0001] The invention relates to a method for synthesizing tocopherol succinate. Background technique

[0002] Vitamin E has significant functions of anti-aging, anti-tumor, preventing cardiovascular and cerebrovascular diseases, and improving immunity of the body. It is an indispensable vitamin in human life activities. Vitamin E contains phenolic hydroxyl groups in its structure, so it is easily oxidized. At the same time, because it is a fat-soluble vitamin, it has brought certain restrictions on the application in some occasions.

[0003] Existing related patents also use enzyme-catalyzed esterification reaction, using tocopherol and succinic acid as raw materials. Other literatures on the synthesis of tocopherol succinate include the use of tocopherol and acid anhydride as raw materials, which require neutralization and washing, resulting in a large amount of waste water and environmental problems.

[0004] In recent years, researchers from all over the...