Compound rifampin capsules and preparation method thereof
A technology for rifampicin and rifampicin, which is applied in the field of medicine, can solve the problems of complex preparation methods, difficult to achieve precise control and the like, and achieve the effects of improving drug efficacy and preventing contact reactions.
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Embodiment 1
[0028] (1) Preparation of rifampicin coated pellets
[0029] Prescription: rifampicin 75g, microcrystalline cellulose 10g, ethanol 250g, talcum powder 3g, hypromellose succinate 10g; preparation process: pass the above-mentioned prescription raw materials and auxiliary materials through a 100-mesh sieve, weigh according to the prescription amount, Mix evenly, add ethanol and stir to form a soft material, pass through a 40-mesh sieve to granulate, then dry at 45°C for 1 hour, add talcum powder, and pass through an 80-mesh sieve to granulate to obtain a tablet core; correctly weigh hypromellose amber Ethyl acid ester, add 200g of ethanol to dissolve and stir evenly to obtain an enteric coating solution; put the above-mentioned tablet core in the coating pan, roll the coating pan, spray the enteric coating solution while blowing hot air, take it out and dry it at 45°C for 2 hours. Delifampicin coated pellets, ready for use.
[0030] (2) Preparation of isoniazid coated pellets
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Embodiment 2
[0036] (1) Preparation of rifampicin coated pellets
[0037] Prescription: rifampicin 75g, chitosan 10g, ethanol 250g, magnesium stearate 2g, hydroxypropyl methylcellulose phthalate 9g;
[0038] Preparation process: pass the above-mentioned prescription raw materials and auxiliary materials through a 100-mesh sieve, weigh them according to the prescription amount, mix them evenly, add ethanol and stir into a soft material, pass through a 40-mesh sieve to granulate, then dry at 45°C for 1 hour, and then add stearic acid The magnesium is then granulated through an 80-mesh sieve to obtain tablet cores; correctly weigh hydroxypropylmethylcellulose phthalate, add 200 g of ethanol to dissolve and stir evenly to obtain an enteric coating solution; place the above-mentioned tablet cores in a coating pan Inside, roll the coating pan, spray the enteric coating liquid while blowing hot air, take it out and dry at 45°C for 2 hours to obtain the rifampicin-coated pellets, set aside.
[00...
Embodiment 3
[0045] (1) Preparation of rifampicin-coated pellets
[0046] Prescription: rifampicin 75g, microcrystalline cellulose 10g, ethanol 150g, zinc stearate 3g, shellac 10g;
[0047] Preparation process: pass the above-mentioned prescription raw materials and auxiliary materials through a 100-mesh sieve, weigh them according to the prescription amount, mix them evenly, add ethanol and stir into a soft material, pass through a 40-mesh sieve to granulate, then dry at 45°C for 1 hour, and then add stearic acid Zinc passes through an 80-mesh sieve to granulate to obtain tablet cores; correctly weigh shellac, add 100 g of ethanol to dissolve and stir evenly to obtain an enteric coating solution; place the above-mentioned tablet cores in a coating pan, roll the coating pan, and spray While blowing hot air on the enteric coating solution, take it out and dry it at 45°C for 2 hours to obtain the rifampicin-coated pellets, which are ready for use.
[0048] (2) Preparation of isoniazid coate...
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