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Mesoporous calcium magnesium silicate/wheat protein composite material as well as preparation method and application of composite material

A technology of mesoporous calcium magnesium silicate and wheat protein, applied in medical science, prosthesis, etc., can solve the problems of acidic degradation products, poor biocompatibility, less bone tissue repair, etc., and achieve good biological activity and repeatability. And the effect of high stability and good mechanical properties

Inactive Publication Date: 2015-06-24
THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention overcomes the difficulty in meeting the requirements of extracellular scaffold materials for bone tissue engineering with a single type of material in the prior art, and the existing composite materials containing mesoporous calcium magnesium silicate are less used for bone tissue repair and degraded The speed is too slow, the biocompatibility is poor, and the existing composite material containing wheat protein degrades too fast, and the degradation products make the system slightly acidic. A kind of mesoporous calcium magnesium silicate / wheat protein composite material and its Preparation method and application

Method used

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  • Mesoporous calcium magnesium silicate/wheat protein composite material as well as preparation method and application of composite material
  • Mesoporous calcium magnesium silicate/wheat protein composite material as well as preparation method and application of composite material
  • Mesoporous calcium magnesium silicate/wheat protein composite material as well as preparation method and application of composite material

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Experimental program
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Effect test

Embodiment 1

[0051] The preparation method of mesoporous calcium magnesium silicate:

[0052] (1) 4g of triblock copolymer P 123 Dissolve in a mixed solution of 120mL 2M hydrochloric acid and 30mL deionized water until clear;

[0053] (2) Add 9.2mL of tetraethyl orthosilicate TEOS, 4.8197g of magnesium nitrate hexahydrate and 5.23g of calcium nitrate tetrahydrate into the prime number mixed solution and stir vigorously at 50°C for 5 hours to form a stable and transparent sol;

[0054] (3) Place the sol obtained in step (2) in a constant temperature shaking box at 37°C for aging and drying, and heat it up to 600°C at a heating rate of 1°C / min for 6 hours of heat preservation and calcination.

[0055] Transmission electron microscope image of mesoporous calcium magnesium silicate figure 1 Shown, among them, a is the transmission electron microscope image enlarged by 50nm, and b is the transmission electron microscope image enlarged by 20nm.

[0056] The preparation method of composite por...

Embodiment 2

[0061] The preparation method of mesoporous calcium magnesium silicate:

[0062] (1) 2g of triblock copolymer P 123 Dissolve in a mixed solution of 100mL 1M hydrochloric acid and 20mL deionized water until clear;

[0063] (2) Add 8mL of TEOS, 4g of magnesium nitrate hexahydrate and 4g of calcium nitrate tetrahydrate into the prime number mixed solution and stir vigorously at 50°C for 4 hours to form a stable and transparent sol;

[0064] (3) Place the sol obtained in step (2) in a 30°C constant temperature shaking box for aging and drying, and heat it up to 500°C at a heating rate of 2°C / min for 5 hours of heat preservation and calcination.

[0065] The preparation method of composite porous support material:

[0066] (1) After mixing mesoporous calcium magnesium silicate and prolamin wheat protein at a mass ratio of 2:7, weigh 0.5 g, then add 5 g of sodium chloride particles with a particle size of 450-550 μm and mix evenly to obtain a mixture; Add absolute ethanol to the ...

Embodiment 3

[0070] The preparation method of mesoporous calcium magnesium silicate:

[0071] (1) 6g of triblock copolymer P 123 Dissolve in a mixed solution of 150mL 1M hydrochloric acid and 30mL deionized water until clear;

[0072] (2) Add 10mL of tetraethyl orthosilicate TEOS, 6g of magnesium nitrate hexahydrate and 6g of calcium nitrate tetrahydrate into the prime number mixed solution and stir vigorously at 50°C for 6 hours to form a stable and transparent sol;

[0073] (3) Place the sol obtained in step (2) in a constant temperature shaking box at 40°C for aging and drying, and heat it up to 700°C at a heating rate of 1.5°C / min for 7 hours of heat preservation and calcination.

[0074] The preparation method of composite porous support material:

[0075] (1) After mixing mesoporous calcium magnesium silicate and prolamin wheat protein at a mass ratio of 2:9, weigh 0.5 g, then add 4 g of sodium chloride particles with a particle size of 450-550 μm and mix evenly to obtain a mixture...

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Abstract

The invention discloses a mesoporous calcium magnesium silicate / wheat protein composite material as well as a preparation method and an application of the composite material. The method comprises the following steps: (1) mixing a mixture of mesoporous calcium magnesium silicate, wheat protein and a pore-foaming agent with a solvent A evenly to obtain slurry; (2) extruding and molding the slurry obtained from the step (2) to obtain a precursor; and (3) soaking the precursor obtained from the step (2) into a solvent B, removing the pore-foaming agent, and carrying out freeze drying. The preparation method disclosed by the invention is relatively simple and relatively high in repeatability and stability; the prepared composite material has a multi-stage aperture structure, has large specific surface area and good mechanical property, can form an active interface together with tone tissues when being implanted into a body, and has good biological activity; a good growth environment is provided for cells; the composite material can be continuously degraded in Tris-HCl and PBS buffer solutions; regeneration of tissue cells is regulated and controlled, so that the bone tissue is successfully repaired; and the composite material has potential application prospect in the field of bone tissue engineering.

Description

technical field [0001] The invention relates to a mesoporous calcium magnesium silicate / wheat protein composite material and its preparation method and application. Background technique [0002] Scaffold materials play an extremely important role in bone tissue engineering. They not only play an important role in connecting and supporting cells, but also regulate biological behaviors such as cell morphology, specific adhesion, proliferation, and directional differentiation. The repair quality and long-term effect after bone grafting, so the research on scaffold materials is currently the most active field of bone tissue engineering research. [0003] Generally used scaffold materials are divided into two categories: natural materials and synthetic materials. Natural materials are represented by bovine cancellous bone carriers; in terms of artificially synthesized inorganic materials, the most common inorganic materials include: hydroxyapatite, tricalcium phosphate, bioactiv...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61L27/56A61L27/58A61L27/50
Inventor 张继生牛云飞安晓飞申晓军姚如永茹江英吴详何大为
Owner THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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