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Preparation method of bulk drug of lysine acetate

A technology of lysine acetate and lysine hydrochloride, which is applied in the field of amino acid preparation, can solve the problems of insufficient environmental protection of ammonia gas, environmental pollution, and high energy consumption of ammonia, so as to improve market competitiveness, solve consumption and salt pollution, and reduce water pollution. the effect of consumption

Inactive Publication Date: 2015-08-12
WUXI JINGHAI AMINO ACID
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the whole process, elution of lysine consumes a large amount of ammonia water, and the subsequent heating and vacuum concentration to catch ammonia consumes high energy consumption, and the volatilization of a large amount of ammonia gas is not environmentally friendly; the elution and regeneration process of the detachable column requires strong alkali and strong acid solution, and the elution of lysine also requires the use of a large amount of ammonia solution
Strong alkali, strong acid and ammonia solution are not environmentally friendly and can easily cause environmental pollution

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The preparation of embodiment 1 lysine acetate

[0020] After dissolving 10kg of lysine hydrochloride with water, the diluted solubility is 20% (g / 100ml water). The aqueous solution of lysine hydrochloride is electrodialyzed with a special heterogeneous metal membrane (EPL4016C of Hangzhou Lanran Environmental Technology Co., Ltd. ) Dechlorination, the volume of the clear solution after dechlorination is twice the volume of the concentrated solution, the conductivity of the clear solution after dechlorination is ≤400μs / cm, and the yield is ≥99%.

[0021] Add the concentrated lysine solution into a 100L reaction kettle, add glacial acetic acid with the same number of moles as lysine, adjust the pH value to 7.0, and react at 70-80°C for 2 hours to obtain a lysine acetate solution. Use a filter membrane with a molecular weight cut-off of 400Da to filter the lysine acetate solution; then use 767 activated carbon with a dry matter mass fraction of lysine acetate of 0.2% for ...

Embodiment 2

[0022] The preparation of embodiment 2 lysine acetate

[0023] After 100kg of lysine hydrochloride is dissolved in water, the diluted solubility is 20%. The lysine hydrochloride aqueous solution is dechlorinated by a special heterogeneous metal membrane through electrodialysis. After dechlorination, the clear night conductivity is ≤350μs / cm, and the yield is ≥98%.

[0024] Add the lysine solution into a 1000L reaction kettle, add glacial acetic acid with 1.1 moles of lysine, adjust the pH value to 7.0, and react at 70-80°C for 2 hours to obtain a lysine acetate solution. Use a filter membrane with a molecular weight cut-off of 500Da to filter the lysine acetate solution; then decolorize the lysine acetate with 767 activated carbon with a dry matter mass of 0.3%; Liquid; concentrated by vacuum segmental evaporation, the evaporation temperature of the first stage is 65 ° C, concentrated to the saturation critical point, then transferred to the second concentration stage, the ev...

Embodiment 3

[0025] The preparation of embodiment 3 lysine acetate

[0026] After 500kg of lysine hydrochloride is dissolved in water, the diluted solubility is 20%. The lysine hydrochloride aqueous solution is dechlorinated by a special heterogeneous metal membrane through electrodialysis. The clear volume after dechlorination is twice the volume of the concentrated solution. The conductivity of the clear night after chlorine is ≤300μs / cm, and the yield is ≥97%.

[0027] Add the lysine solution into a 5000L reaction kettle, add glacial acetic acid with 1.2 times the molar number of lysine, adjust the pH value to 7.0, and react at 70-80°C for 2 hours to obtain a lysine acetate solution. Use a filter membrane with a molecular weight cut-off of 600Da to filter the lysine acetate solution; then decolorize the lysine acetate with 767 activated carbon with a dry matter mass of 0.4%; after decolorization, filter the lysine acetate with a molecular weight cut-off membrane of 8000Da Liquid; conce...

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Abstract

The invention discloses a preparation method of a bulk drug of lysine acetate and belongs to the field of amino acid preparation. The preparation method includes following steps: preparing lysine hydrochloride into a water solution, dechlorinating the water solution to obtain a high-purity lysine solution through an electrodialysis system, performing a reaction to the lysine solution with glacial acetic acid to obtain a lysine acetate water solution, and further nano-filtering, decoloring, ultra-filtering and concentrating and crystallizing the lysine acetate water solution to obtain the bulk drug of lysine acetate. In the method, a conventional ion exchange column dechlorinating method is abandoned so that the preparation method is free of acid, alkali, ammonia water and such solutions, thereby reducing environmental pollution. A special vacuum-sectionalized concentration and crystallization process is employed to obtain a crystal of the lysine acetate being better in crystal form and higher in light transmittance, thereby improving production quality.

Description

technical field [0001] The invention relates to a preparation method of a lysine acetate bulk drug, which belongs to the field of amino acid preparation. Background technique [0002] L-Lysine is one of the essential amino acids for the human body, because it is not only a basic nutrient for human health, but also has anti-inflammatory and analgesic effects, liver cell protection, immunity enhancement, and anti-tumor effects in disease treatment. . Medical compound amino acid injection can not only provide patients with essential nutrients, but also has good effects in treating burns, liver diseases, kidney diseases, encephalopathy, etc. Lysine is one of the main raw materials for compound amino acid injection. Due to the poor chemical stability of lysine, it was often used as lysine hydrochloride in the early stage. The compound amino acid infusion prepared with lysine hydrochloride has high chloride ion content, and some patients are not suitable for it. Therefore, more...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/26C07C227/18
Inventor 宁健飞蔡立明
Owner WUXI JINGHAI AMINO ACID
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