Collagen/silk fibroin composite support and manufacturing method and application thereof

A technology of silk fibroin and composite scaffold, applied in medical science, prosthesis, etc., can solve the problems of inaccessibility, poor strength, etc., and achieve the effects of good mechanical properties, favorable adhesion and excellent biocompatibility

Inactive Publication Date: 2015-09-09
ZHENDE MEDICAL CO LTD
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Problems solved by technology

[0004] Collagen is the substantive tissue that constitutes the largest amount of connective tissue protein, and is the main component of the extracellular matrix. Its ultrastructure and stability play an extremely important role in cell-cell and cell-matrix interactions; it has a wide range of Its act

Method used

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  • Collagen/silk fibroin composite support and manufacturing method and application thereof
  • Collagen/silk fibroin composite support and manufacturing method and application thereof

Examples

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[0022] A collagen / silk fibroin composite scaffold, comprising a collagen-based porous scaffold and a silk non-woven fabric, the silk non-woven fabric is more tightly integrated in the collagen-based porous scaffold, and the collagen-based porous scaffold has 30- 500μm pore size structure; silk fibroin non-woven fabric has good three-dimensional porous structure and permeability, the pore size range is between 20-3000μm, and the diameter of a single cooked silk is about 10μm, such as figure 1 shown.

[0023] The quantitative relationship between the silk fibroin nonwoven fabric and the collagen-based scaffold can be adjusted according to the different uses of the scaffold and the properties of the target tissue / organ. In addition to collagen, the materials used to prepare collagen-based porous scaffolds can also use chitosan, hyaluronic acid, silk fibroin, chondroitin sulfate, glycosaminoglycans, elastin and its hydrolyzate, laminin, Bone morphogenic protein, cellulose, etc. ...

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Abstract

The invention discloses a collagen/silk fibroin composite support and a manufacturing method and application thereof. The collagen/silk fibroin composite support comprises a collagen-based porous support body and fibroin non-woven fabric. The fibroin non-woven fabric is closely integrated in the collagen-based porous support body. The collagen-based porous support body is provided with an aperture structure of 30-500 [u]m. The fibroin non-woven fabric is provided with a good three-dimensional porous structure and has good permeability. The aperture ranges from 20 [u]m to 3,000 [u]m. The diameter of single bright silk is about 10 [u]m, and generally ranges from 8 [u]m to 12 [u]m. The collagen/silk fibroin composite support obtained through the manufacturing method is excellent in biocompatibility and mechanical performance and is provided with a non-woven fabric structure with certain biodegradability. Tissue engineering skin construction can be met well. Then, skin wound healing is accelerated, and healing quality is improved.

Description

technical field [0001] The invention relates to a tissue engineering scaffold, in particular to a collagen / silk fibroin composite scaffold, a preparation method and an application thereof. Background technique [0002] Once the dermis is damaged, it cannot be completely regenerated. In clinical practice, autologous, allogeneic or xenograft skin grafts are usually used to repair large areas of deep skin damage. Or it is difficult to heal by itself; on the other hand, the sources of skin grafts available for transplantation are limited, and there may be adverse reactions such as infection and rejection, and sometimes it is difficult to achieve the ideal repair effect. The basic idea of ​​skin tissue engineering is to rebuild damaged dermal tissue to make dermal regeneration possible. [0003] Silk fibroin is one of the outstanding representatives of natural biological materials. It is safe, non-toxic, non-irritating, and has unique mechanical properties and good biological ac...

Claims

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Application Information

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IPC IPC(8): A61L27/48A61L27/22A61L27/24
Inventor 韩春茂王新刚鲁建国有传刚胡修元胡烨婷
Owner ZHENDE MEDICAL CO LTD
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