An enzyme-responsive magnetic nanoparticle and its preparation method and application
A magnetic nanoparticle, enzyme-responsive technology, applied in the field of medicine, to achieve the effect of strong targeting, rich sources and good use effect
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Embodiment 1
[0014] In concrete implementation, the present invention is realized by the following steps:
[0015] 1) Synthesis of Fe 3 o 4 Nanoparticles: Weigh FeSO 4 ·7H 2 O 3.36g and FeCl 3 ·6H 2 O 3.2g, dissolved in 80mL ultrapure water, in N 2 Protect and stir at 80°C for 30 minutes, then add 8mL of ammonia water, the solution turns black, continue to stir for 30 minutes, weigh 1.6g of citric acid and dissolve it in 3.2mL of ultrapure water, then add to the above black solution, heat up to 95°C, React for 90 minutes, magnetically separate to obtain a precipitate, wash the precipitate 3 times, and vacuum dry at 60°C to obtain Fe 3 o 4 Nanoparticles;
[0016] 2) Synthesis of magnetic Fe 3 o 4 @Cu 2-x S nanomaterials: Weigh 3.6mmoL sublimated sulfur and dissolve it in 2.4mL oleylamine, add 0.16mmoL Fe 3 o 4 In 8 mL of cyclohexane containing nanoparticles, stir at 70°C for 10 min to form sublimated sulfur and Fe 3 o 4 cyclohexane mixed solution; in addition, 0.4mmoL copper ...
Embodiment 2
[0019] The present invention can also be realized by the following steps in concrete implementation:
[0020] 1) Synthesis of Fe 3 o 4 Nanoparticles: Weigh FeSO4 ·7H 2 O 4.2g and FeCl 3 ·6H 2 O 4.0g, dissolved in 100mL ultrapure water, in N 2 Protect and stir at 80°C for 30 minutes, then add 10mL of ammonia water, the solution turns black, continue to stir for 30 minutes, weigh 2g of citric acid and dissolve it in 4mL of ultrapure water, then add to the above black solution, heat up to 95°C, and react for 90min , magnetically separated to obtain a precipitate, which was washed three times with water, and dried under vacuum at 60°C to obtain Fe 3 o 4 Nanoparticles;
[0021] 2) Synthesis of magnetic Fe 3 o 4 @Cu 2-x S nanomaterials: Weigh 4mmoL sublimated sulfur and dissolve it in 3mL oleylamine, add 0.2mmoL Fe 3 o 4 In 10 mL of cyclohexane containing nanoparticles, stir at 70°C for 10 min to form sublimated sulfur and Fe 3 o 4 cyclohexane mixed solution; in additi...
Embodiment 3
[0024] In concrete implementation, the present invention is realized by the following steps:
[0025] 1) Synthesis of Fe 3 o 4 Nanoparticles: Weigh FeSO 4 ·7H 2 O 50.4g and FeCl 3 ·6H 2 O 4.8g, dissolved in 120mL ultrapure water, in N 2 Protect and stir at 80°C for 30 minutes, then add 10mL of ammonia water, the solution turns black, continue to stir for 30 minutes, weigh 2.4g of citric acid and dissolve it in 4.8mL of ultrapure water, then add to the above black solution, heat up to 95°C, React for 90 minutes, magnetically separate to obtain a precipitate, wash the precipitate 3 times, and vacuum dry at 60°C to obtain Fe 3 o 4 Nanoparticles;
[0026] 2) Synthesis of magnetic Fe 3 o 4 @Cu 2-x S nanomaterials: Weigh 4.8mmoL sublimated sulfur and dissolve it in 3.6mL oleylamine, add 0.24mmoL Fe 3 o 4 In 12 mL of cyclohexane containing nanoparticles, stir at 70°C for 10 min to form sublimated sulfur and Fe 3 o 4 cyclohexane mixed solution; in addition, 0.6mmoL copp...
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