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Preparation method and application of three-dimensional interpenetrating porous magnesium-based material

A technology of porous magnesium and base materials, applied in prosthetics, medical science, etc., can solve problems such as the inability to guarantee the uniformity of the pore structure, the connectivity of the pore structure, the corrosion of the metal of the magnesium matrix of the pore-forming agent, and achieve the protection of integrity and purity. , uniform distribution of pores, easy operation

Active Publication Date: 2015-11-11
SHANGHAI JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

During the powder sintering process, due to the non-uniform particle morphology of these pore-forming agents, effective fusion contact points cannot be established between the particles during the sintering process, so these methods cannot guarantee the uniformity of the pore type and the connectivity of the pore structure. ; In addition, during the removal of the pore-forming agent, the residue of the pore-forming agent and the corrosion of the pore-forming agent to the magnesium matrix metal will also occur

Method used

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  • Preparation method and application of three-dimensional interpenetrating porous magnesium-based material

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Embodiment 1

[0030] This embodiment relates to a degradable three-dimensional open-pore porous magnesium alloy used in the field of tissue engineering. The pore type is spherical and the pore diameter is 400-600 μm. It is 150-250 μm, and the porosity is 75%. Its structure is as figure 1 As shown in the physical figure, it can be seen that the spherical hole type and the connected holes evenly distributed on the hole wall.

[0031] This embodiment relates to the aforementioned degradable three-dimensional open-pore porous magnesium and magnesium alloy preparation method for tissue engineering, and the method includes the following steps:

[0032] Step 1, conduct spark plasma sintering of spherical titanium particles with a size of 400-600 μm, the sintering temperature is 800°C, the heating rate is 20°C / min, the pressure is 5MPa, heat preservation and pressure for 3 minutes, and then naturally cool to obtain a porous titanium ball preform ;

[0033] Step 2: Fill the Mg-5wt.%Zn-1wt.%Mn all...

Embodiment 2

[0036] This embodiment relates to a degradable open-pore porous magnesium alloy used for bone tissue engineering scaffolds. The pore type is spherical and the pore diameter is 400-600 μm. It is 250-350 μm, and the porosity is 85%.

[0037] This embodiment relates to the aforementioned degradable open-pore porous magnesium and magnesium alloy preparation method for tissue engineering scaffolds, the method includes the following steps:

[0038]Step 1. Spherical iron particles with a size of 400-600 μm are subjected to spark plasma sintering. The sintering temperature is 900°C, the heating rate is 40°C / min, and the pressure is 10MPa. After holding the heat for 3 minutes, cool naturally to obtain the porous iron ball preform with open pores. ;

[0039] Step 2: Fill the Mg-3wt.%Nd-0.2wt.%Zn-0.5wt.%Zr-0.5wt.%Ca alloy into the gap of the porous iron ball preform by infiltration casting at 720°C and a pressure of 6MPa , and air-cooled to room temperature to obtain a composite block ...

Embodiment 3

[0042] This embodiment relates to a degradable open-pore porous magnesium alloy used for tissue engineering scaffolds. The pore type is spherical and the pore diameter is 800-1000 μm. ~500μm, the porosity is 90%.

[0043] This embodiment relates to the aforementioned degradable three-dimensional open-pore porous pure magnesium preparation method for tissue engineering scaffolds, and the method includes the following steps:

[0044] Step 1, hot isostatic pressing sintering of spherical titanium particles with a size of 600-800 μm, the sintering temperature is 1000°C, the heating rate is 100°C / min, the pressure is 50MPa, heat preservation and pressure holding for 5 minutes, then naturally cool to obtain open porous iron balls Preform;

[0045] Step 2: Fill the pure magnesium melt into the gap of the porous iron ball preform by percolation casting at 720°C and a pressure of 0.1 MPa, and air-cool to room temperature to obtain a composite block of the preform and pure magnesium; ...

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Abstract

The invention discloses a degradable three-dimensional porous magnesium-based biomaterial and a preparation method thereof. The porous magnesium and magnesium alloy materials are in a three-dimensional through complete opening structure; the hole pattern is a sphere with a controllable dimension; intercommunicating holes are uniform in distribution and controllable in dimension; and a magnesium fluoride film is uniformly generated on the surface of each hole wall. The holes of the material obtained by the method are uniform in overall distribution; the porosity and the mechanical property are controllable; titanium sphere or iron sphere particles are sintered in preparation, so as to obtain a porous preform with spherical openings; magnesium and magnesium alloy infiltrate into the preform and then are cooled to room temperature; and the preform is removed through hydrofluoric acid solution corrosion. The preparation method is simple in preparation technology and convenient to operate; an anti-corrosion anti-fouling membrane is formed on a magnesium and magnesium alloy matrix surface in the removal process of the preform; the magnesium-based biomaterial is good in connectivity, and relatively high in porosity and strength; the hole wall is free of corrosion or pore-forming agent residue phenomenon; a closed hole does not exist; and the magnesium-based biomaterial can be used as a new generation of degradable tissue engineering scaffold.

Description

technical field [0001] The invention belongs to the technical field of material preparation, and relates to a design method for a three-dimensional open porous material, and relates to a preparation method and application of a three-dimensional connected porous magnesium-based material. Background technique [0002] Among biomedical metal implant materials, magnesium and magnesium alloys have attracted worldwide attention and research due to their good mechanical properties, biocompatibility and in vivo degradability, and have become a new generation of bone implants. It is an ideal material for vascular stents, dental and orthopedic implants, and is known as a "revolutionary metal biomaterial". The porous magnesium-based biomaterial with a three-dimensional penetrating network structure not only plays the role of tissue filling at the implant site, but also promotes the growth of blood vessels and surrounding tissues through its own pore structure, so that the implant does ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C1/08C22C23/00A61L27/04A61L27/56
CPCA61L27/04A61L27/56C22C23/00C22C1/08C22C23/04A61L27/047
Inventor 袁广银贾高智
Owner SHANGHAI JIAOTONG UNIV
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