A method for preparing curcumin-loaded polyacrylonitrile fiber by dope dyeing method

A technology of curcumin-loaded polyacrylonitrile fiber and dope coloring, applied in spinning solution preparation, wet spinning, dry spinning, etc., can solve the problems of high pollution, high cost, high energy consumption, etc.

Active Publication Date: 2017-09-29
LANGSHA KNITTING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention is to overcome the problems of high cost, high pollution, high energy consumption and resource type in the production process of the existing traditional dyeing process, and to color the chemical fiber polyacrylonitrile spinning slurry by the dope coloring method

Method used

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  • A method for preparing curcumin-loaded polyacrylonitrile fiber by dope dyeing method
  • A method for preparing curcumin-loaded polyacrylonitrile fiber by dope dyeing method

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0022] A kind of stock solution coloring method prepares the method that loads curcumin polyacrylonitrile fiber:

[0023] The first step is to prepare spinning dope. First prepare the polyacrylonitrile spinning stock solution according to the existing technology, wherein the dry solid content A of polyacrylonitrile is 99 parts by weight, then add curcumin and drug transdermal absorption accelerator into the spinning stock solution and stir evenly, The dry solid amount B that adds curcumin is 0.5 weight part, and the drug transdermal absorption accelerator that adds is oleic acid, and dry solid amount C is 0.5 weight part, and analytical pure N, N-dimethylacetamide (DMAc) aqueous solution is used as Solvent, D is 400 parts by weight, (A+B+C): (A+B+C+D)=20%.

[0024] The second step is to make polyacrylonitrile fiber from the spinning stock solution containing curcumin and drug transdermal absorption accelerator, adopt wet spinning process, and use 50% N,N-dimethylacetamide aqu...

Embodiment 2

[0026] In the present embodiment, the dry solid content A of polyacrylonitrile is 85 parts by weight, then curcumin and drug transdermal absorption accelerator are added in this spinning dope and stirred evenly, the dry solid content B of adding curcumin is 10 parts by weight part, the drug transdermal absorption accelerator added is oleic acid, and the dry solid content C is 5 parts by weight, and analytically pure N,N-dimethylacetamide (DMAc) aqueous solution is used as solvent, and D is 355 parts by weight, (A+ B+C): (A+B+C+D) = 22%. The dry-jet wet-spinning process is adopted, the 50% N,N-dimethylacetamide aqueous solution at 5°C is used as the coagulation bath, the three-stage drafting is carried out, and the bright yellow drug-loaded fiber is finally made into a winding roller. Other methods are the same as in Example 1.

Embodiment 3

[0028] In the present embodiment, the dry solid content A of polyacrylonitrile is 80 parts by weight, then curcumin and drug transdermal absorption accelerator are added in this spinning dope and stirred evenly, the dry solid content B of adding curcumin is 15 parts by weight part, the drug transdermal absorption accelerator added is azone, and the dry solid amount C is 5 parts by weight, and the analytically pure N,N-dimethylacetamide (DMAc) aqueous solution is used as a solvent, and D is 456 parts by weight, (A+ B+C): (A+B+C+D) = 18%. The dry-jet wet-spinning process is adopted, the 50% N,N-dimethylacetamide aqueous solution at 5°C is used as the coagulation bath, the three-stage drafting is carried out, and the bright yellow drug-loaded fiber is finally made into a winding roller. Other methods are the same as in Example 1.

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Abstract

The invention discloses a method for preparing curcumin-loaded polyacrylonitrile fibers by the coloring method of stock solution. The spinning solution composed of polyacrylonitrile, curcumin, a transdermal absorption promoter and a solvent can adopt a wet spinning process or a dry process. Spinning process or dry jet wet spinning process. The obtained fiber has a beautiful yellow color, and can be directly used as a colored fiber without dyeing processing, and the color fastness is ≥ 4 to 5 grades; it is used as a drug-loaded functional fiber, which has a drug-sustained release effect, is convenient to use, and has few side effects; Fibers possess weavable mechanical properties and can be woven into fabrics.

Description

technical field [0001] The invention relates to a method for preparing curcumin-loaded polyacrylonitrile fibers by a stock solution coloring method, and belongs to the cross field of biomedicine and material processing technology. Background technique [0002] Curcumin (curcumin) is a plant polyphenol extracted from the rhizome turmeric of the ginger plant (Curcuma Longa L.), with the molecular formula C 21 h 20 o 6 , the molecular weight is 368.39. Studies in recent years have shown that curcumin has a wide range of pharmacological effects, such as anti-oxidation, anti-tumor, anti-ischemia, lowering blood lipids, etc., and has low toxicity. It also has the functions of protecting the kidney, inhibiting pulmonary fibrosis, inhibiting liver fibrosis, and helping muscle damage repair , treating cataracts, anti-parasitic diseases, multiple pharmacological effects, and less toxic and side effects, safe to use, and has a good clinical application prospect. At the same time, i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01F6/18D01F1/06D01F1/10D01D1/02D01D5/06D01D5/04A61K47/32A61K31/12A61P39/06A61P35/00A61P9/10A61P3/06A61P13/12A61P1/16A61P11/00A61P21/00A61P27/12A61P33/00
Inventor 翁荣弟刘爱莲柴红梅周冰情
Owner LANGSHA KNITTING
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