A medical suture with high mechanical strength

Abstract

The invention discloses a medical suture thread with high mechanical strength. The raw materials include: 80-100 parts of modified chitosan, 1-ethyl-(3-dimethylaminopropyl) carbodiimide 1-5 parts of hydrochloride, 2-6 parts of mannitol, 1-3 parts of tea tree oil; wherein, the preparation method of modified chitosan is: adding carboxymethyl chitosan to dissolve in water, filling inert gas, Heat up, add glutaraldehyde, polyvinylpyrrolidone and N, N-methylenebisacrylamide, keep warm, purify, and obtain the intermediate material; add the intermediate material in the second solvent and mix, fill inert gas, add chlorinated tin, adding polyethylene lactide solution, vacuuming, heating, heat preservation, purification, to obtain modified chitosan. The invention has good compatibility with biological tissue, easy adhesion and propagation of cells on the invention, high mechanical performance, good tensile strength and good knotting strength.

Description

technical field [0001] The invention relates to the technical field of medical sutures, in particular to a medical suture with high mechanical strength. Background technique [0002] Among the absorbable sutures made of natural materials, chitosan sutures have good biocompatibility, have the advantages of antibacterial ability, chemical inertness, and no foreign body reaction to tissues. Produce irritation, allergies, and inflammation, and have the advantages of anti-inflammatory, promoting wound healing, and smoothing the wound after healing. [0003] However, the mechanical strength of chitosan is not high. When it is implanted into the human body through surgical suture, it will degrade under the action of body fluid soaking and enzymes, which will reduce the mechanical strength of the suture, weaken the function or lose it prematurely, and the tensile strength is not high enough. , poor knot strength, resulting in a mismatch between the degradation rate of the suture an...

AI Technical Summary

Problems solved by technology

[0003] However, the mechanical strength of chitosan is not high. When it is implanted into the human body through surgical suture, it will degrade under the action of body fluid soaking and enzymes, which will reduce the mechanical strength of the suture, weaken the function or lose it prematurely, and the tensile strength is not high enough. , poor knot strength, resulting in a mismatch between the degradation rate of the suture and the rate of wound healing

Moreover, chitosan has poor solubility and is not easy to process. In order to overcome the above defects, it is necessary to develop absorbable medical sutures with high mechanical properties and good tensile strength.