Cefaclor compound, medicine composition of cefaclor compound and bromhexine hydrochloride, and preparation of cefaclor compound

A technology of bromhexine hydrochloride and cefaclor, applied in the field of medicine, can solve problems such as research on bioavailability of preparations, and achieve the effects of good clinical treatment effect, good stability and improved synergistic drug effect

Active Publication Date: 2015-11-25
SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
8 Cites 3 Cited by

AI-Extracted Technical Summary

Problems solved by technology

[0008] However, the above patents did not conduct in-d...
View more

Abstract

The invention relates to the field of medicines, in particular to a cefaclor trihydrate and a preparation thereof. The cefaclor trihydrate has a structural formula shown in formula (I). The invention further relates to a medicine composition prepared from the cefaclor trihydrate and bromhexine hydrochloride. The form of the medicine composition is selected from tablets, capsules and granules. Stability tests prove that the prepared cefaclor trihydrate is high in stability and bioavailability, and suitable for clinical application.

Application Domain

Antibacterial agentsOrganic active ingredients +1

Technology Topic

DrugDosage form +6

Image

  • Cefaclor compound, medicine composition of cefaclor compound and bromhexine hydrochloride, and preparation of cefaclor compound
  • Cefaclor compound, medicine composition of cefaclor compound and bromhexine hydrochloride, and preparation of cefaclor compound
  • Cefaclor compound, medicine composition of cefaclor compound and bromhexine hydrochloride, and preparation of cefaclor compound

Examples

  • Experimental program(14)
  • Comparison scheme(3)

Example Embodiment

[0039] Example 1 Preparation of Cefaclor Trihydrate
[0040] 1. Dissolve the crude cefaclor in water with a pH of 3.0 and a temperature of 40°C;
[0041] 2. While stirring, add a mixed solvent of diethyl ether and n-hexane in a volume ratio of 2:1; the stirring speed is 1200 rpm; the weight of the mixed solvent is 4 times the weight of the cefaclor aqueous solution, and the adding speed is 30 ml/min;
[0042] 3. After the mixed solvent is added, the temperature is lowered to -1°C, and the cooling rate is 4°C/hour; adjust the pH to 4.5 to obtain crystals and then stand for crystallization; filter, wash, and vacuum dry for 2 hours to obtain cefaclor III Hydrate.
[0043] The compound crystals were tested by high performance liquid chromatography, the purity was 99.96%, the yield was 94.0%; the X-ray powder diffraction pattern obtained by Cu-Kα ray measurement is as follows figure 1 As shown, the thermogravimetric analysis diagram is as figure 2 Shown; elemental analysis (%) measured value:
[0044] C (42.710), H (4.740), N (9.965), Cl (8.400), O (26.550), S (7.610).

Example Embodiment

[0045] Example 2 Preparation of Cefaclor Trihydrate
[0046] 1. Crude cefaclor is dissolved in water with a pH of 2.5 and a temperature of 35°C;
[0047] 2. While stirring, add a mixed solvent of diethyl ether and n-hexane with a volume ratio of 2:0.8; the stirring speed is 1000 rpm; the weight of the mixed solvent is 3 times the weight of the cefaclor aqueous solution, and the adding speed is 20 ml/min;
[0048] 3. After the mixed solvent is added, the temperature is lowered to 0°C, and the cooling rate is 5°C/hour; adjust the pH to 5.0 to obtain crystals and then stand for crystallization; filter, wash, and vacuum dry for 4 hours to obtain cefaclor trihydrate Things.
[0049] The compound crystals were tested by high performance liquid chromatography, and the purity was 99.95%, and the yield was 93.5%; the X-ray powder diffraction pattern obtained by Cu-Kα ray measurement is as follows figure 1 As shown, the thermogravimetric analysis diagram is as figure 2 Shown; elemental analysis (%) measured values: C (42.710), H (4.740), N (9.965), Cl (8.400), O (26.550), S (7.610).

Example Embodiment

[0050] Example 3 Preparation of Cefaclor Trihydrate
[0051] 1. The crude cefaclor is dissolved in water with a pH of 3.0 and a temperature of 38°C;
[0052] 2. While stirring, add a mixed solvent of diethyl ether and n-hexane with a volume ratio of 4:1; the stirring speed is 900 rpm; the weight of the mixed solvent is 3 times the weight of the cefaclor aqueous solution, and the adding speed is 20 ml/min;
[0053] 3. After the mixed solvent is added, the temperature is lowered to -1°C, and the cooling rate is 4°C/hour; adjust the pH to 4.5 to obtain crystals and then stand for crystallization; filter, wash, and vacuum dry for 3 hours to obtain cefaclor III Hydrate.
[0054] The compound crystals were tested by high performance liquid chromatography, the purity was 99.96%, the yield was 94.2%; the X-ray powder diffraction pattern obtained by Cu-Kα ray measurement is as follows figure 1 As shown, the thermogravimetric analysis diagram is as figure 2 Shown; elemental analysis (%) measured values: C (42.710), H (4.740), N (9.965), Cl (8.400), O (26.550), S (7.610).

PUM

no PUM

Description & Claims & Application Information

We can also present the details of the Description, Claims and Application information to help users get a comprehensive understanding of the technical details of the patent, such as background art, summary of invention, brief description of drawings, description of embodiments, and other original content. On the other hand, users can also determine the specific scope of protection of the technology through the list of claims; as well as understand the changes in the life cycle of the technology with the presentation of the patent timeline. Login to view more.

Similar technology patents

Classification and recommendation of technical efficacy words

  • Simple preparation process
  • high purity

Low-platinum high active core-shell structure catalyst and preparation method thereof

InactiveCN101664685AAddress performance and costSimple preparation process
Owner:NORTHWEST NORMAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products