A kind of preparation method of saw palmetto phytene sustained-release tablet

A technology of alkene sustained-release tablet and phytate, which is applied in the directions of non-active ingredients medical preparations, active ingredients-containing medical preparations, pharmaceutical formulas, etc. and other problems, to achieve the effect of easy control of dosage, low bioavailability and simple preparation method

Active Publication Date: 2017-11-10
煌途医药(无锡)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention: the bioavailability of ordinary tablets and capsules made of saw palmetto extract is low, easy to volatilize, the dosage is not easy to control, it is inconvenient to carry, and the disintegration time of soft capsules is prolonged after being placed for a long time , the active ingredients are reduced in efficacy at the end of the validity period, resulting in the increase of the amount of feed and the increase in production costs during production. A preparation method for saw palmetto phytene sustained-release tablets is provided. The present invention is to take polylactic acid resin particles and Mix dichloromethane and other substances, then mix with polyvinyl alcohol, etc., centrifuge, wash and dry to obtain polyvinyl alcohol sustained-release microsphere carrier for later use; take gelatin and water and mix to obtain gelatin solution, mix with polyvinyl alcohol and other aqueous solutions, and then mix with phytic acid Mix the phytene sustained-release coating colloid with ethylene, lay the die flat, gently press the polyvinyl alcohol sustained-release microsphere carrier into half of the phytene sustained-release coating colloid, and add the remaining colloid into the mold , made by tableting

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0016] First by mass parts, choose 25 parts of polylactic acid resin particles, 25 parts of mass fraction as 45% methylene chloride, 35 parts of liquid paraffin and 15 parts of sorbitan fatty acid ester, at 70 ℃ Mix and stir for 30min, and the mixing and stirring speed is 880r / min. During the stirring and mixing process, 200W ultrasonically assisted vibration for 2min, so that the polylactic acid resin particles are evenly dispersed in methylene chloride, and the polylactic acid emulsion is prepared; At ℃, according to the number of parts by mass, respectively select 35 parts of polylactic acid emulsion prepared above, 30 parts of polyvinyl alcohol and 35 parts of polysorbate, first stir and mix at 2000rpm for 2min, and then place it at 500rpm Stir under magnetic force for 4 hours, then let it stand for cooling, and centrifuge at 4000rpm for 20 minutes, take out the lower layer of sediment, wash it twice with deionized water, dry it in an oven at 60°C for 10 hours, take it out ...

example 2

[0019]First, in terms of parts by mass, 10 parts of polylactic acid resin particles, 30 parts of mass fraction of 45% dichloromethane, 40 parts of liquid paraffin and 20 parts of sorbitan fatty acid ester were selected, at 75 ° C Mix and stir for 30min, and the mixing and stirring speed is 1030r / min. During the stirring and mixing process, 250W ultrasonic assisted vibration for 3min, so that the polylactic acid resin particles are evenly dispersed in methylene chloride, and the polylactic acid emulsion is prepared; At ℃, according to the number of parts by mass, respectively select 25 parts of the polylactic acid emulsion prepared above, 35 parts of polyvinyl alcohol and 40 parts of polysorbate, first stir and mix at 2000rpm for 3min, and then place it at 500rpm Stir under magnetic force for 4.5h, then let it stand for cooling, and centrifuge at 4500rpm for 25min, take out the lower layer of sediment, wash with deionized water for 3 times, dry in an oven at 70°C for 11h, take i...

example 3

[0022] First by mass parts, choose 20 parts of polylactic acid resin particles, 32 parts of mass fraction of 45% methylene chloride, 30 parts of liquid paraffin and 18 parts of sorbitan fatty acid ester, at 80 ℃ Mix and stir for 30min, and the mixing and stirring speed is 1180r / min. During the stirring and mixing process, 300W ultrasonically assisted vibration for 3min, so that the polylactic acid resin particles are uniformly dispersed in methylene chloride, and the polylactic acid emulsion is prepared; At ℃, according to the number of parts by mass, respectively select 39 parts of polylactic acid emulsion prepared above, 28 parts of polyvinyl alcohol and 33 parts of polysorbate, first stir and mix at 2000rpm for 3min, and then place it at 500rpm Stir under magnetic force for 5 hours, then let it stand for cooling, and centrifuge at 5000rpm for 30 minutes, take out the lower layer of sediment, wash with deionized water for 3 times, dry in an oven at 80°C for 12 hours, take it ...

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Abstract

The invention discloses a preparation method of saw palmetto phytene sustained-release tablets and belongs to the field of preparation of phytene sustained-release tablets. The phytic acid pinene sustained-release tablet of the present invention is obtained by taking polylactic acid resin particles and dichloromethane and other materials for ultrasonic vibration and mixing, then mixing with polyvinyl alcohol and polysorbate, centrifugally washing and drying to obtain the polyvinyl alcohol sustained-release microsphere carrier for use; Gelatin is mixed with water to obtain gelatin solution, mixed with mannan polysaccharide aqueous solution and polyvinyl alcohol aqueous solution, and then mixed with phytene and crosslinking agent to obtain phytene sustained-release coating colloid. The release microsphere carrier is lightly pressed into half of the phytic acid pinene slow-release coated colloid, and then the remaining phytic acid pinene slow-release coated colloid is added to the mold and pressed into tablets. The beneficial effects of the present invention are: the obtained Saw Palmetto Phytate Pine Sustained-release Tablet has good slow-release effect, low bioavailability, not easy to volatilize, easy to control dosage, easy to carry, can be stored for 1 to 2 years, and the obtained product has no Any pungent odor.

Description

technical field [0001] The invention relates to a preparation method of saw palmetto phytene sustained-release tablets and belongs to the field of preparation of phytene sustained-release tablets. Background technique [0002] Saw palmetto, also known as saw palmetto leaves or saw palmetto, scientifically named "Sabah palm", belongs to the shrubs of the palm family. The ripe, dried fruit of the leaf palm is used medicinally. The extract of Saw Palmetto fruit is a powerful natural treatment for BPH. Saw palmetto extract can effectively inhibit the activity of 5a-reductase, reduce the production of dihydrotestosterone, antagonize the combination of androgen and androgen receptor in prostate tissue; it has adrenergic antagonism and calcium blocking effect, so as to improve bladder function, Antispasmodic effect; it can also inhibit the activity of cyclooxygenase and lipoxygenase, reduce the production of leukotrienes, prostaglandins and other inflammatory mediators, thus play...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22A61K31/6615A61K47/32A61K47/34A61K47/42A61P13/02A61P13/08A61P13/10
Inventor 王新良陈丽霞刘清茂
Owner 煌途医药(无锡)有限公司
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