A kind of preparation method of flower-shaped hydroxyapatite whisker

Abstract

A method for preparing flower-shaped hydroxyapatite whiskers, using calcium carbonate and phosphoric acid as raw materials, controlling the mass ratio of phosphoric acid to calcium carbonate to be greater than 3:1, placing light calcium carbonate in a phosphoric acid solution whose pH value has been adjusted, Stirring is carried out to obtain the precursor. The precursor is placed in a hydrothermal reaction kettle for hydrothermal reaction. After the reaction is completed, it is cooled to room temperature, and the obtained product is taken out, washed with water three times and washed with alcohol three times in sequence, and centrifuged to remove reaction residues and impurities. After drying the obtained product in a constant temperature drying oven, flower-shaped hydroxyapatite whiskers can be obtained. The aspect ratio of the prepared hydroxyapatite flower-shaped whiskers is controllable, and the shape is uniform and the fracture toughness is significantly improved. , has the characteristics of low cost, high yield, simple process and strong repeatability.

Description

technical field [0001] The invention relates to the technical field of preparation of bioceramic materials, in particular to a method for preparing flower-shaped hydroxyapatite whiskers. Background technique [0002] Hydroxyapatite (HAp) has excellent biocompatibility and bioactivity, and its osteoinductive activity is more prominent. As a special form of hydroxyapatite whiskers, it not only retains excellent biological properties, And it has higher tensile properties and lower dislocation density. As fibers grown in the form of single crystals, HAp whiskers are stronger and tougher than ordinary hydroxyapatite ceramics by about 3～8 It can be used as a reinforcement or filler for hard tissue repair ceramic materials. HAp whiskers absorb energy in bioceramics through deflection effect, bridging effect, pull-out effect and micro-crack effect, and eliminate the concentrated stress at the tip of the crack, which can greatly improve the toughness of the material. Based on its m...

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Problems solved by technology

People such as Sun Kangning (Chinese patent, publication number CN 102431986 A) invented a kind of preparation method of hydroxyapatite nanofiber, and this method is to utilize homogeneous precipitation method to produce HAp nanofiber, and its diameter is about 20 ～30 nm, the length is about 200 ～ 900nm, the aspect ratio is basically controllable, and there are no other impurity phases, but the whole process needs to add the template agent cetyltrimethylammonium bromide (CTAB), and the crystallinity and shape uniformity of the product are not high, which can be repeated Poor sex

The hydrothermal method is currently the most common and mature method for preparing hydroxyapatite whiskers. Zhang Jizhong (Chinese patent, publication number CN 101297978 A) invented a method for preparing hydroxyapatite nanorods. It is carried out under the oleic acid-ethanol-water phase transfer system, and the prepared HAp powder has uniform size, controllable shape, and low production cost, but there are many kinds of medicines required, and the paper does not describe the reaction kettle when it is hydrothermal. Optimum parameters of filling degree and reaction system pressure

Zhang Meijuan (Chinese Patent, Publication No. CN 101723341 A) invented a method for preparing hydroxyapatite nanofibers or nanowires. It is described in the article that the prepared hydroxyapatite nanowires have high purity, uniform particle size, and single shape. The introduction of calcium source is not mentioned in the example, and the yield is not high

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