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Preparation method of an electroactive amphiphilic polymer molecularly imprinted sensor

An amphiphilic polymer, molecular imprinting technology, applied in the direction of electrochemical variables of materials, can solve the problems of slow electron transfer rate and low sensitivity of molecularly imprinted sensors, and achieve the effects of improved sensitivity, sensitive detection, and simple synthesis process.

Active Publication Date: 2019-03-29
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the fly in the ointment is that molecularly imprinted polymers are not conductive, and their insulating properties make the electron transfer rate slower, and the resulting molecularly imprinted sensors have low sensitivity.

Method used

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  • Preparation method of an electroactive amphiphilic polymer molecularly imprinted sensor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Preparation of electroactive amphiphilic polymer:

[0026] Synthesis of electroactive amphiphilic polymer poly(N-vinylcarbazole-co-acrylic acid-co-isooctyl acrylate). Take by weighing 1.93g (0.01mol) N-vinyl carbazole, 3.13g (0.017mol) isooctyl acrylate, 1.23g (0.017mol) acrylic acid, 0.11g (0.0007mol) azobisisobutyronitrile (by monomer 1.5% of the total molar weight) in a 50mL round-bottomed flask, add 20mL dioxane and stir to dissolve. Charge N 2 Deoxygenated and sealed, reacted in an oil bath at 75°C for 24 hours, precipitated with petroleum ether three times, dissolved in tetrahydrofuran twice, and dried under vacuum at 30°C after the precipitate was washed. A pure electroactive amphiphilic polymer is obtained.

[0027] (2) Preparation of electroactive amphiphilic polymer solution:

[0028] Dissolve 0.1 g of the polymer prepared in step (1) and 0.01 g of acetaminophen in 10 mL of DMF to prepare a polymer solution with a polymer concentration of 10 mg / mL and ...

Embodiment 2

[0034] (1) Preparation of electroactive amphiphilic polymer:

[0035] Synthesis of electroactive amphiphilic polymer poly(vinylaniline-co-dimethylaminoethyl methacrylate-co-isodecyl acrylate). Weigh 0.6g (0.005mol) vinylaniline, 1.7g (0.008mol) isodecyl acrylate, 2.15g (0.015mol) dimethylaminoethyl methacrylate, 0.049g (0.0003mol) azobisisobutyl Nitrile (according to 1.0% of the total molar weight of the monomer) was added into 20 mL of dioxane in a 50 mL round bottom flask and stirred to dissolve. Charge N 2 Deoxygenated and sealed, reacted in an oil bath at 65°C for 36 hours, precipitated with petroleum ether three times, dissolved in tetrahydrofuran twice, and dried under vacuum at 35°C after the precipitate was washed. A pure electroactive amphiphilic polymer is obtained.

[0036] (2) Preparation of electroactive amphiphilic polymer solution:

[0037] Dissolve 0.2 g of the polymer prepared in step (1) and 0.02 g of ascorbic acid in 10 mL of DMF to prepare a polymer sol...

Embodiment 3

[0043] (1) Preparation of electroactive amphiphilic polymer:

[0044] Synthesis of electroactive amphiphilic polymer poly(vinylthiophene-co-sodium p-styrenesulfonate-co-hydroxyethyl acrylate). Weigh 0.33g (0.003mol) vinylthiophene, 0.58g (0.005mol) hydroxyethyl acrylate, 2.47g (0.012mol) sodium p-styrenesulfonate, 0.049g (0.0003mol) azobisisobutyronitrile (according to 1.5% of the total molar weight of monomers) in a 50 mL round bottom flask, was added into 20 mL of dioxane and stirred to dissolve. Charge N 2 Deoxygenated and sealed, reacted in an oil bath at 85°C for 12 hours, precipitated with petroleum ether three times, dissolved in tetrahydrofuran twice, and dried in vacuum at 25°C after the precipitate was washed. A pure electroactive amphiphilic polymer is obtained.

[0045] (2) Preparation of electroactive amphiphilic polymer solution:

[0046] Dissolve 0.05 g of the polymer prepared in step (1) and 0.005 g of dopamine in 10 mL of DMF to prepare a polymer solution ...

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Abstract

The invention provides a preparation method of an electro-active amphiphilic polymer molecular imprinting sensor and relates to the technical field of combination of high-molecular material science and electro-chemical sensors. The preparation method includes the following steps: synthesizing an electro-active amphiphilic random copolymer through free radical polymerization; performing self-assembly to prepare a molecular imprinting electro-active polymer micelle with detection substances, which are common in food security and bio-medicines, as template molecules; and performing electro-deposition, electro-polymerization and elution of template molecules to obtain the electro-active amphiphilic polymer molecular imprinting sensor. The electro-active amphiphilic polymer molecular imprinting sensor has excellent sensitivity and recognition capability on a template molecule, is high in responding speed and good in stability and can be used repeatedly.

Description

technical field [0001] The invention provides a preparation method of an electroactive amphiphilic polymer molecularly imprinted sensor, and relates to the technical field of combining polymer material science with electrochemical sensors. Background technique [0002] Molecular imprinting technology has received great attention due to its effective application in separation, catalysis, chemical / biosensors and biomedical materials. Molecular imprinting technology (MIT) is a technique for preparing molecularly imprinted copolymers (MIPs) that have a selective and specific binding effect on template molecules and have specific spatial conformation holes. The polymers prepared in the early traditional method of preparing molecularly imprinted copolymers have a large number of molecular recognition sites embedded in the highly cross-linked polymers, resulting in high selectivity of the imprinted materials, but due to the template Difficulty in molecular elution leads to the sho...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/26G01N27/30G01N27/36
Inventor 罗静马强刘鹤刘晓亚
Owner JIANGNAN UNIV
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