Blumea balsamifera volatile oil suppository and preparation process thereof
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A technology of volatile oil and oil suppository, which is applied in the field of medicine and can solve problems such as short residence time, toxic side effects, drug resistance, etc.
Inactive Publication Date: 2016-01-27
TROPICAL CORP STRAIN RESOURCE INST CHINESE ACAD OF TROPICAL AGRI SCI +1
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Problems solved by technology
[0005] At present, the drugs used to treat bacterial infections are mostly antibiotics, such as dacryline ointment, ciprofloxacin suppository, metronidazole suppository, estriol ointment, miconazole suppository, α-interferon suppository, etc. These antibiotics are prone to cause Drug resistance and side effects
However, traditional dosage forms such as lotion and ointment have a short residence time at the action site, and it is difficult to reach an effective concentration, and they are easily excreted.
Method used
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Embodiment 1
[0081] This embodiment provides a suppository of volatile oil of Ainaxiang, which is a suppository comprising at least the following components: volatile oil of Ainaxiang, base, surfactant, and preservative.
[0082] The components of the Ainaxiang volatile oil suppository, in parts by weight, are: Ainaxiang volatile oil 1.0, matrix 9.0, surfactant 0.1, and preservative 0.05.
[0083] The matrix is preferably a mixture of polyethylene glycol 6000 and polyethylene glycol 4000, and the matrix is prepared by the following method: take polyethylene glycol 6000, polyethylene glycol 4000 and distilled water, place the weighted In the evaporating dish, the water bath is heated and melted, and stirred evenly to make a water-soluble matrix; the weight ratio of polyethylene glycol 6000, polyethylene glycol 4000, and water in the matrix is 5:3:2.
[0084] The surfactant is polysorbate-80.
[0085] The preservative is potassium sorbate.
[0086] Preferably, described Ai Naxiang vo...
Embodiment 2
[0097] This embodiment provides a preparation process of Ainaxiang volatile oil suppository, comprising the following steps:
[0098] 1) Weigh polyethylene glycol 6000, polyethylene glycol 4000 and distilled water, put them in a weighed evaporating dish, heat and melt in a water bath, stir evenly, and make a water-soluble matrix;
[0099] 2) Accurately weigh the volatile oil of Ainaxiang, put it in a weighed evaporating dish, add surfactant and preservative, then add the prepared molten polyethylene glycol mixed matrix, heat and melt in a water bath at 60-65°C, and stir evenly ; The 60-65°C molding temperature is moderate, which will not affect the fluidity of the drug, cause uneven mixing, and will not destroy the active ingredients of the drug;
[0100] 3) After stirring evenly, quickly pour into the suppository mold that has been coated with lubricant, solidify and release the mold, and absorb the moisture on the surface of the suppository with absorbent paper.
[0101] De...
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Abstract
The present invention discloses a blumea balsamifera volatile oil suppository and a preparation process thereof, wherein the components of the suppository at least comprise blumea balsamifera volatile oil and an auxiliary material. The preparation process comprises: preparing blumea balsamifera volatile oil; adding an auxiliary material to the blumea balsamifera volatile oil, and carrying out water bath heating melting; and filling into a suppository mold, curing, and demolding. According to the present invention, the blumea balsamifera plant resource is rich, the material is easy to obtain, and the cost is low; the blumea balsamifera volatile oil suppository reaches the affected area through the local action, and has characteristics of long residence time, rapid efficacy providing, good bioavailability, first pass effect reducing, toxic-side effect reducing, and good efficacy obtaining; the blumea balsamifera volatile oil suppository preparation process is simple, and is suitable for industrialization; the blumea balsamifera volatile oil suppository has characteristics of wide application people, good patient compliance, a certain economic and social benefit, and the like; and the blumea balsamifera volatile oil suppository provides good research basis for the development of new traditional Chinese medicine dosage forms for treatment of gynecological vaginitis and other diseases, and provides a certain promotion effect for the traditional Chinese medicine modernization and international development.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to an Ainaxiang volatile oil suppository and a preparation process thereof. Background technique [0002] Gynecological vaginitis is an inflammation of the vaginal mucosa and submucosal connective tissue, which belongs to the category of "vaginal itching" in traditional Chinese medicine. It is a common gynecological inflammatory disease and can be suffered by all age groups. The main cause of gynecological inflammation caused by vaginitis is that damp heat and poisonous qi take advantage of the deficiency and accumulate in the uterus, causing dysfunction of qi and blood in viscera. [0003] Ainaxiang belongs to the genus Ainaxiang in the family Asteraceae, and the Miao medicine name is Wokai plant. The medicinal parts are branches, leaves and twig roots. Ainaxiang is mainly distributed in Guangdong, Guangxi, Yunnan, Hainan and other places in my country. Worldwide distribution ma...
Claims
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Application Information
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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/02A61K36/28A61K47/34A61P15/02
Inventor 不公告发明人
Owner TROPICAL CORP STRAIN RESOURCE INST CHINESE ACAD OF TROPICAL AGRI SCI
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