Microencapsulated animal drug and preparation method thereof

Abstract

The invention discloses a microencapsulated animal drug which comprises the following synthesis raw materials in parts by weight: 9-29 parts of drug, 56-86 parts of wall material and 3-7 parts of an emulsifying agent. The invention further relates to a preparation method for the microencapsulated animal drug. The preparation method comprises the following steps: 1) preparing raw materials, 2), dissolving the wall material into water so as to obtain a water phase A; 3), dissolving the drug into a solvent, and adding the emulsifying agent so as to obtain an oil phase B; 4), under the condition of high shearing and high stirring, adding the oil phase B into the water phase A, stirring and emulsifying at a high speed and heating to remove the solvent so as to obtain microemulsion; 5), adding the obtained microemulsion into a spray granulation tower and mixing the microemulsion with corn starch or rice bran, and carrying out spray-drying, so as to obtain the microencapsulated animal drug granules or powder. The microencapsulated animal drug prepared through the preparation method disclosed by the invention is good in covering effect and good in flowing properties and the purposes of masking the smell, preventing dampness, and improving drug stability and drug bioavailability are realized.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a microencapsulated animal medicine and a preparation method thereof. Background technique [0002] Microcapsule technology is a technology that uses natural or synthetic polymer film-forming materials (wall materials) to embed liquid or solid drugs (capsule materials) to form tiny capsule particles with a diameter of 100-500 μm. The process of preparing microcapsule particles is referred to as microencapsulation. Widely used in additives, intermediates, pharmaceuticals, pesticides, petrochemicals, environmental protection, fine chemicals and other industries. Drug microencapsulation has the following characteristics: 1. It can reduce the incompatibility of drugs in compound preparations and isolate the reaction between drug components; 2. Cover up the bitterness or peculiar smell of drugs and reduce gastrointestinal irritation; 3. Control the drug For release, iner...

AI Technical Summary

Problems solved by technology

There are three main forms of preparing microencapsulated drugs in the prior art: one is the high-temperature spray method, which is not suitable for easily oxidized and heat-sensitive materials due to the high temperature of the inlet air, and the coating rate is not high, and it is easy to break the wall. Affect the use of drugs or other active ingredients

The second is the boiling granulation method. The powdery material is put into a closed container. Due to the hot air flow, the powdery material is suspended in the container in a fluidized state. At the same time, the adhesive is sprayed and atomized to agglomerate the powder. into small particles, but the production equipment of this method is mostly batch production, which cannot meet the requirements of the assembly line, and the product particles are irregular, and it is also not suitable for easily oxidized and heat-sensitive materials.

The third is the fluidized bed coating method, which is the main method for forming microcapsules of powdery and crystalline drugs based on physical and mechanical principles, but the coated drugs have a large specific surface area, and particles often occur during the preparation process. The phenomenon of adhesion and electrostatic adsorption, and the coating process takes a long time, consumes a lot of energy, high production cost and low production efficiency

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