Terbinafine hydrochloride compound composition and preparation method and application

A technology of terbinafine hydrochloride and composition, which is applied in the field of terbinafine hydrochloride compound composition and preparation, can solve the problems of ergosterol deficiency, fungal cell death, etc., and achieve improved compliance, simple formula, and reproducible good sex effect

Inactive Publication Date: 2016-02-10
QINGDAO HAIZHIYUAN INTELLIGENT TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Terbinafine hydrochloride specifically interferes with the early steps of fungal sterol biosynthesis, thereby causing ergosterol deficiency and intracellular accumulation of squalene, leading to fungal cell death

Method used

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  • Terbinafine hydrochloride compound composition and preparation method and application
  • Terbinafine hydrochloride compound composition and preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027]A compound composition of terbinafine hydrochloride, the components and parts by weight of the composition include: 5 parts of terbinafine hydrochloride, 50 parts of seaweed, 35 parts of Cyperus cyperi, 20 parts of Amomum chinensis, 40 parts of licorice, 30 parts of myrrh, 20 parts of herb, 35 parts of dried hemp, 35 parts of cicada slough, 25 parts of water hyacinth fruit, 20 parts of flower ant insect, 30 parts of jellyfish, 20 parts of sugar powder, 25 parts of sodium carboxymethyl starch, 0.5 part of talcum powder, 0.5 part of polyoxyethylene fatty acid ester.

[0028] A preparation method of terbinafine hydrochloride compound composition, comprises the steps:

[0029] 1) preparing materials, preparing materials according to the components and parts by weight of a terbinafine hydrochloride compound composition, wherein terbinafine hydrochloride is pulverized through a 100 mesh sieve, powdered sugar, sodium carboxymethyl starch, talcum powder , polyoxyethylene fatty ...

Embodiment 2

[0036] A compound composition of terbinafine hydrochloride, the components and parts by weight of the composition include: 10 parts of terbinafine hydrochloride, 60 parts of seaweed, 40 parts of Cyperus cyperi, 25 parts of Amomum chinensis, 45 parts of licorice, 35 parts of myrrh, 25 parts of herb, 40 parts of dried hemp, 40 parts of cicada slough, 30 parts of water hyacinth, 25 parts of flower ant insect, 35 parts of jellyfish, 25 parts of sugar powder, 30 parts of sodium carboxymethyl starch, 1 part of talcum powder, 1 part of polyoxyethylene fatty acid ester.

[0037] A preparation method of terbinafine hydrochloride compound composition, comprises the steps:

[0038] 1) preparing materials, preparing materials according to the components and parts by weight of a terbinafine hydrochloride compound composition, wherein terbinafine hydrochloride is pulverized through a 100 mesh sieve, powdered sugar, sodium carboxymethyl starch, talcum powder , polyoxyethylene fatty acid est...

Embodiment 3

[0045] A compound composition of terbinafine hydrochloride, the components and parts by weight of the composition include: 7 parts of terbinafine hydrochloride, 56 parts of seaweed, 39 parts of Cyperus cyperi, 21 parts of Amomum chinensis, 43 parts of licorice, 34 parts of myrrh, 22 parts of herb, 36 parts of dried hemp, 38 parts of cicada slough, 29 parts of water hyacinth, 23 parts of flower ant insects, 34 parts of jellyfish, 22 parts of powdered sugar, 27 parts of sodium carboxymethyl starch, 0.8 part of talcum powder, 0.6 part of polyoxyethylene fatty acid ester.

[0046] A preparation method of terbinafine hydrochloride compound composition, comprises the steps:

[0047] 1) preparing materials, preparing materials according to the components and parts by weight of a terbinafine hydrochloride compound composition, wherein terbinafine hydrochloride is pulverized through a 100 mesh sieve, powdered sugar, sodium carboxymethyl starch, talcum powder , polyoxyethylene fatty ac...

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Abstract

The invention discloses a terbinafine hydrochloride compound composition and a preparation method and application. The compound composition is prepared from terbinafine hydrochloride, seaweed, rhizoma cyperi, amomun fruit, licorice roots, myrrh, rhizoma atractylodis, roots of angled bittersweet, periostracum cicada, phoenix eye nuts, yellow ants, Japanese worms, powdered sugar, powdered sugar, talcum powder and polyoxyethylene aliphatate. The preparation method comprises the steps of raw material preparation, extraction of effective components of traditional Chinese medicine active pharmaceutical ingredients, granulation, size stabilization and tabletting. According to the compound composition, a mixture of traditional Chinese medicine and western medicine is adopted, both symptoms and root causes of tinea are treated, the therapeutic advantages of the traditional Chinese medicine and the western medicine are both exerted, and the toxic and side effects of the terbinafine hydrochloride are overcome. The method capable of killing bacteria, diminishing inflammation, promoting granulation, draining toxin, removing pain, relieving itching, clearing heat, promoting eruption and removing moisture is adopted to rapidly relieve the symptoms such as pain, red swelling, pruritus, erosion and desquamation of a patient, and then a therapeutic method capable of tonifying Qi, strengthening the spleen, helping digestion, promoting the appetite, promoting Qi circulation to relieve distension, regulating the stomach and preventing or arresting vomiting is adopted to overcome the side effects of the terbinafine hydrochloride.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a compound composition of terbinafine hydrochloride, a preparation method and application thereof. Background technique [0002] Terbinafine hydrochloride is an allylamine antifungal drug, which inhibits squalene cyclooxygenase in the process of ergosterol synthesis in fungal cells, and makes squalene accumulate in cells to play a bactericidal effect. The sensitivity of human cells to terbinafine hydrochloride is one ten thousandth of that of fungi. It has a broad-spectrum antifungal effect, has a bactericidal effect on skin fungi, and has a bacteriostatic effect on Candida albicans. It is suitable for skin and nail infections caused by superficial fungi, such as tinea corporis, jock itch, athlete's foot, onychomycosis, and skin Candida albicans infections caused by Trichophyton, Microsporum canis, and Epidermophyton flocculus. Terbinafine hydrochloride specifically...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61P17/00A61P31/10A61K35/64A61K31/137
Inventor 王芬黄清华赵田孙强
Owner QINGDAO HAIZHIYUAN INTELLIGENT TECH
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