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Surface modifying method of orthopedic implanted medical instrument

A surface modification and device technology, which is applied in the fields of pharmaceutical formulation, dentistry, medical science, etc., can solve the problems of curative effect discount, lack of targeting mechanism, etc., and achieve the effect of preventing loosening and increasing service life

Active Publication Date: 2016-02-17
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this invention is still limited to the systemic administration of the above two types of drugs, and lacks a targeting mechanism. When the drug concentration is fixed, the effective concentration of the drug reaching the lesion is reduced due to blood dilution and metabolism, and the curative effect is greatly reduced.

Method used

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  • Surface modifying method of orthopedic implanted medical instrument
  • Surface modifying method of orthopedic implanted medical instrument
  • Surface modifying method of orthopedic implanted medical instrument

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1. Preparation of "Sr-BPs" film layer by "micro-arc oxidation-simulated body fluid method"

[0043] The Ti-6Al-4V porous scaffold 3D printed by electron beam melting was used as the sample. It has been determined that its diameter is 10mm, its height is 5mm, its pillar and pore size are about 400μm and 682μm respectively, and its porosity is 73% ( figure 2 ). The above scaffolds were powder blown, acetone-ethanol-deionized water ultrasonically cleaned and dried at 60°C, and then placed at room temperature for subsequent processing. Under the scanning electron microscope, some incompletely melted titanium powder microspheres bonded to the surface can be observed.

[0044] Firstly, a strontium-doped calcium phosphate surface (pretreatment film layer) with biological activity and microporous structure is prepared. Micro-arc oxidation was carried out in constant voltage mode by using JHMAO-6H pulsed DC power supply of Beijing Golden Arc Lvbao. The above bracket...

Embodiment 2

[0047] Example 2, "Sr-BPs" film layer prepared by "micro-arc oxidation-hydrothermal method"

[0048]The microporous structure on the surface of the stent after the above-mentioned micro-arc oxidation endows it with a large specific surface area and reactivity, which can be used as a template for a secondary reaction, and then induced by the hydrothermal reaction of a weak alkaline solution. With the micropores as the center, it can be used in A disordered nanorod-like structure is formed at its periphery. The "micropore-nanorod" composite hierarchical structure (intermediate layer) has a higher specific surface area and biological activity than a single microporous structure, and can directly utilize the PO of BPs without SBF induction. 4 3- and the Ca-rich surface of the nanorods 2+ The principle of electrostatic adsorption combined with BPs. The morphology of nanorods after adsorbing BPs is as follows: Figure 4 shown. The bright area in the figure is the C-rich element...

Embodiment 3

[0052] Example 3, "Sr-BPs" film layer prepared by "alkali heat-simulated body fluid method"

[0053] First, according to every 5-10mL alkaline solution / sample, use NaOH solution with a concentration gradient of 1M, 2.5M, 5M, 10M to carry out alkaline heat treatment at a temperature of 100-240°C, and the reaction time varies from 1-48h, so that the final Nanowire (nanofiber) film layers with different thicknesses and diameters were obtained on the surface of the titanium alloy. The obtained scaffold was washed with a large amount of deionized water to remove residual alkaline ions, and then dried at 60°C. Through this step, we can obtain nanowires with a diameter of 8-10 nm and a length of tens of microns to hundreds of microns ( Figure 5 ). In terms of composition, the nanowire "kaolin-like" layered structure has a large lattice activity and a super ion exchange capacity. Therefore most ions (Mg 2+ , Ca 2+ 、Sr 2+ , Zn 2+ 、Ag + 、Cu + etc.) can be compared with the Na ...

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Abstract

The invention discloses a surface modifying method of an orthopedic implanted medical instrument. An active strontium salt and a bisphosphonate are loaded on the surface of the implanted instrument. In-situ long-time controllable release of the active strontium salt (osteogenic component and bone resorption inhibitor) and bisphosphonate (bone resorption inhibitor) around the implanted instrument, synergistic effect of the active strontium salt and the bisphosphonate is utilized, and inhibiting of absorption of original bones and promoting of generation of new bones are realized so as to achieve the objective of quick-sound integration of an orthopedic transplanted device (prosthesis) with surrounding bone tissue. The orthopedic implanted instrument realizing surface modification through the method is especially suitable for treatment of pathologically induced bone absorption and fracture patients.

Description

technical field [0001] The invention relates to a method for modifying the surface of orthopedic medical devices, especially for bone resorption around implants after orthopedic (prosthetic) transplantation and osteoporosis patients who need orthopedic (prosthetic) transplantation, and belongs to the surface modification method of medical materials. Sexuality and its drug sustained release field. Background technique [0002] A major problem faced by patients with orthopedic graft components or joint prostheses (such as hip and knee replacements) is that most prostheses start to fail around five years after implantation, with a failure rate of 20–30% and a rapid rate of failure. Exponential growth. Generally, after 10-15 years of hip joint prosthesis, the aging phenomenon of the implant will occur. Not only the prosthesis is loose, the function is gradually lost, but also the implant site is frequently painful, and a second revision operation is eventually required. The pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/28A61L27/30A61L27/54A61K6/02
Inventor 贾昭君成艳修鹏
Owner PEKING UNIV
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