A cis-lycopene preparation boosting immunity and a preparing method thereof

A cis-lycopene and immunity-enhancing technology, which is applied in pill delivery, active ingredients of hydrocarbon compounds, drug combinations, etc., can solve the problems of loss of curative effect, cis-trans isomerization, oxidative degradation, and difficulty in absorption, etc., to achieve Enhance immunity, stabilize content, and facilitate absorption

Active Publication Date: 2016-03-30
南京远见生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Currently commercially available lycopene preparations are basically soft capsules made of lycopene oleoresin, which mainly include the following: 1. Lycopene is unstable and easily oxidized or decomposed by light to lose its curative effect; 2. Lycopene It mainly exists in the trans structure that is difficult for the human body to absorb; 3. Lycopene is insoluble in water and floats in the gastric juice in the state of oil droplets, which is difficult to absorb
[0005] Due to the special chain structure of lycopene and the existence of unsaturated double bonds, its stability is extremely poor, and it is prone to cis-trans isomerization and oxidative degradation. , heat, and oxygen are more sensitive; therefore, it is particularly important to invent a lycopene preparation rich in cis-lycopene to overcome the defects of the current preparation

Method used

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  • A cis-lycopene preparation boosting immunity and a preparing method thereof
  • A cis-lycopene preparation boosting immunity and a preparing method thereof
  • A cis-lycopene preparation boosting immunity and a preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Mix 100g of lycopene oleoresin (containing 10% lycopene, of which cis-lycopene accounts for 3.1%) with 100g of water and 150g of β-cyclodextrin, stir and grind at 50°C for 60min, transfer the wet material to microwave In the vacuum drying box, the vacuum degree in the box is below 0.1Mpa, turn on the microwave, control the microwave power to 8w / g, and process for 90min. The lycopene / beta-cyclodextrin mixture in the obtained product is crushed and sieved after 2.5 parts of the above mixture Add 1 part of microcrystalline cellulose, 1 part of pregelatinized starch, 0.01 part of sodium carboxymethyl starch, 0.01 part of silicon dioxide, and 0.01 part of magnesium stearate, mix well, and directly compress the whole powder into tablets, 500 mg per tablet, to make The tablet is ready for use, and the content of cis-lycopene in the tablet is 0.8%.

Embodiment 2

[0038] (1) Solubilization experiment

[0039] Standard curve: draw the standard curve of Sudan I pigment according to the GB14215-2008 method, and plot the absorbance value A against C (μg / ml) to obtain the standard curve: A=0.3074C+0.0105 (r=0.9999), λ=485nm.

[0040] Take the lycopene tablets prepared in Example 1 and an appropriate amount (about 5g) of 10% lycopene oleoresin, put them in a 100ml volumetric flask, add purified water (about 80ml), ultrasonicate for 15min, let cool to room temperature, dilute to volume, and filter , take an appropriate amount of filtrate, extract with toluene, dilute, measure the absorbance at 485nm, and calculate the solubility of lycopene and the solubilization multiple according to the absorbance.

[0041]Lycopene oleoresin (10%) has a solubility of lycopene in water at room temperature: 0.086 μg / ml

[0042] The solubility of lycopene tablets in water at room temperature is: 4.958μg / ml

[0043] The results show that: lycopene in the table...

Embodiment 3 Embodiment 1

[0060] The pharmacodynamic test of embodiment 3 embodiment 1 tablet

[0061] 1. Experimental animals and experimental content

[0062] 18-22g healthy female clean-grade ICR mice (animal certificate number: SCXK (Shanghai) 2007-0005), were randomly divided into 4 groups according to body weight in batches, 10 in each group, and were divided into 5 batches for mouse spleen lymphatic Cell transformation test and NK cell activity test; dinitrofluorobenzene-induced delayed-type hypersensitivity (DTH) test in mice; antibody-producing cell test and serum hemolysin test; mouse carbon clearance test; mouse peritoneal macrophages phagocytosis of chicken Red blood cell test. SPF-level experimental animal environmental facility certificate: SYXK (Su) 2012-0037. All animals were given sterilized mouse feed and sterilized water for free access.

[0063] 2. Dose design

[0064] The recommended daily intake for adults (based on 60kg body weight) is 1000mg (total lycopene is 20mg, which con...

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Abstract

A cis-lycopene preparation boosting immunity and a preparing method thereof are disclosed. The cis-lycopene preparation comprises 2.5-11 parts by weight of a raw material rich in cis-lycopene and 0.5-5.23 parts by weight of conventional pharmaceutic adjuvants. The raw material rich in cis-lycopene is prepared by (1) fully mixing lycopene oleoresin with beta-cyclodextrin to form a lycopene-beta-cyclodextrin mixture, and (2) treating the lycopene-beta-cyclodextrin mixture through heating or microwaves under vacuum to convert trans-lycopene into cis-lycopene until the water content is lower than 10.0% so as to obtain the raw material rich in cis-lycopene. The cis-lycopene preparation boosting immunity is provided. The content of the cis-lycopene in the preparation reaches 2% and is stable. The preparation has an effect of boosting immunity.

Description

technical field [0001] The invention belongs to the field of preparations, and relates to a cis-lycopene preparation capable of enhancing immunity and a preparation method thereof. Background technique [0002] Lycopene is a kind of carotenoid, which is a linear polyunsaturated olefin composed of 11 conjugated double bonds and 2 non-conjugated double bonds, and its molecular formula is C 40 h 56 , molecular weight 536.85. Lycopene is widely present in plants, and red fruits such as ripe tomatoes, watermelons, carrots, and red grapefruits contain more red fruits, and it also widely exists in various organs and tissues of the human body, including blood, adrenal glands, Testes, liver, etc. contain more lycopene, because lycopene is a fat-soluble natural pigment used as a food additive, it has a strong ability to scavenge free radicals and resist oxidation, it quenches singlet oxygen, and scavenge free radicals The ability is 100 times that of vitamin E, a commonly used anti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/01A61P37/04A61K9/20
Inventor 孙红日董祥玉孙晓东
Owner 南京远见生物工程有限公司
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