Breast implant three-dimensional structure and rapid forming method thereof

Abstract

The invention provides a breast implant three-dimensional structure and a rapid forming method thereof and belongs to the field of manufacturing of medical equipment, biological materials and organs. A breast implant comprises nerve fiber bundles, blood vessels and a mammary gland system, wherein the nerve fiber bundles and the blood vessels are formed by commixing and printing a synthesized macromolecular solution, a natural macromolecular solution, growth factors and human cells, and then culturing; the mammary gland system comprises adipose tissue, a mammary gland duct and a nipple, and are formed by commixing and printing a synthesized macromolecular solution, growth factors and human stem cells, and then transforming; and the mammary gland system is distributed between a breast dermic layer and chest tissues. By utilizing a composite multi-nozzle 3D printing technology, integrated three-dimensional construction of different materials in different directions is realized; a novel concept and a novel method are provided for rapidly manufacturing an artificial breast implant in vitro; and the disadvantages that structures of previous other forming methods are too simple and the process operation is complicated are overcome, and physiological functions of a plurality of types of structure tissues in a human breast can be simulated very well.

Description

technical field [0001] The invention belongs to the technical field of artificial manufacturing of complex organs of organisms, and involves the use of cells, synthetic polymer materials, cell matrix materials and 3D printing technology and process methods, which is different from previous tissue engineering processes. Background technique [0002] Female breasts have dual functions of lactation, feeding and aesthetics. Due to congenital dysplasia, tumor resection, trauma and other reasons, female micromastia and breast loss will seriously affect the patient's body and mind. According to the American Society of Orthopedic Surgeons, more than 5 million people worldwide underwent breast reconstruction surgery in 2004, 4 million of which were due to tumor resection [2004 American Society of Plastic Surgeons Statistics. Available from: www.plasticsurgery.org]. Breast cancer is one of the most common malignant tumors in women, with an incidence rate of 10-15%, and it is increasin...

AI Technical Summary

Problems solved by technology

[0004] Autologous transplanted fat particles cannot establish a blood supply system well. When a large amount of fat accumulates together, fat cells will be necrotic, dissolved, and absorbed due to insufficient blood supply, which can easily cause infection, hematoma, deformation, pain, induration, cysts, Necrosis and other sequelae [Vallée M, Cote J-F, Frandette J. Adipose-tissue engineering: taking advantage of the properties of human adipose-derived stem / stromal cells. Pathol Biol 2009; 57:309-317]

At present, it is generally believed that 40% to 60% of the fat particles are absorbed, fibrosis or calcification, the effect is not long-lasting, often need multiple injections to maintain the shape

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