Preparation method of biodegradable polyurethane acrylate carrier released by coating medicine

A polyurethane acrylate, biodegradable technology, used in coatings, prostheses, medical science and other directions, can solve problems such as low utilization rate, and achieve the effect of improving hydrophilicity and improving degradation rate

Inactive Publication Date: 2016-05-04
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Microorganisms will form biofilms on the surface of implants or medical equipment, requiring high levels of antibiotics to inhibit bacteria, and the utilization rate is low

Method used

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  • Preparation method of biodegradable polyurethane acrylate carrier released by coating medicine
  • Preparation method of biodegradable polyurethane acrylate carrier released by coating medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Synthesis of polyether ester diol: Add 5.00 g of initiator polyethylene glycol (Mw400) into a 100 mL round bottom flask, vacuumize at 100 ° C for 3 h, then cool down to room temperature, and add ε-caprolactone 32.50g, add catalyst stannous octoate 0.1125g, pass into N 2 Raise the temperature to 130°C, react for 24 hours, and stop the reaction. The obtained product was poured into excess cold n-hexane and diethyl ether, centrifuged and precipitated, dried in a vacuum oven at 50°C for 24 hours, and transferred to a drying tower for later use.

[0023] (2) Preparation of polyurethane acrylate: Add 0.005mol of polyether ester diol to a 100mL round-bottomed flask and vacuumize for 3 hours at 100°C, then cool down to room temperature, and add 0.01mol of hexamethylene diisocyanate and catalyst organic bismuth in turn 0.0500g, reacted at 80°C under nitrogen protection for 3h. The reaction system was cooled to 45°C, and 0.01mol hydroxyethyl methacrylate was added to contin...

Embodiment 2

[0026] (1) Synthesis of polyether ester diol: Add 5 g of polyethylene glycol (Mw400) starter into a 100 mL round bottom flask, vacuumize at 100 °C for 3 h, then cool down to room temperature, add ε-caprolactone 20 g , add 0.075g catalyst stannous octoate, feed N 2 Raise the temperature to 130°C, react for 24 hours, and stop the reaction. The obtained product was poured into excess cold n-hexane and diethyl ether, centrifuged and precipitated, dried in a vacuum oven at 50°C for 24 hours, and transferred to a drying tower for later use.

[0027] (2) Preparation of polyurethane acrylate: Add 0.01mol of the obtained polyether ester diol into a 100mL round-bottomed flask and vacuumize for 3 hours at 100°C, then cool down to room temperature, and add 0.02mol of hexamethylene diisocyanate and catalyst in turn Organic bismuth 0.0700g was reacted at 80°C under nitrogen protection for 3h. Cool the reaction system to 45° C., add 0.02 mol hydroxyethyl methacrylate to continue the reacti...

Embodiment 3

[0030](1) Synthesis of polyether ester diol: Add 5 g of polyethylene glycol (Mw400) starter into a 100 mL round bottom flask, vacuumize at 100 °C for 3 h, then cool down to room temperature, add ε-caprolactone 20 g , add 0.075g of catalyst stannous octoate, pass into N 2 Raise the temperature to 130°C, react for 24 hours, and stop the reaction. The obtained product was poured into excess cold n-hexane and diethyl ether, centrifuged and precipitated, dried in a vacuum oven at 50°C for 24 hours, and transferred to a drying tower for later use.

[0031] (2) Preparation of polyurethane acrylate: Add 0.01mol of the obtained polyether ester diol into a 100mL round-bottomed flask and vacuumize for 3 hours at 100°C, then cool down to room temperature, and add 0.02mol of isophorone diisocyanate and catalyst organic Bismuth 0.0733g was reacted at 80°C under nitrogen protection for 3h. Cool the reaction system to 45° C., add 0.02 mol hydroxyethyl methacrylate to continue the reaction a...

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Abstract

The invention relates to a preparation method of a biodegradable polyurethane acrylate carrier released by coating medicine. The preparation method includes the process that poly(ether-ester) diols is synthesized, a polyurethane acrylate coating is prepared, and medicine loading is performed. The preparation method has the advantages that by means of a molecular design method, a poly(ether-ester) soft segment is introduced in a polyurethane acrylate main chain, the hydrophilicity of the coating can be effectively improved and the degradation rate of the coating can be effectively increased; the polyurethane acrylate coating is obtained through an ultraviolet curing method, and time and labor are saved; after the coating loaded with antibiotics, the antibacterial effect is achieved, the coating is biodegradable, and degradation products of the coating are non-toxic, and it is avoided that pH of the system is changed and inflammation is caused.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a preparation method of a biodegradable polyurethane acrylate carrier coated with drug release. Background technique [0002] Implants or medical device coatings, commercial sterilization techniques are often autoclave, ethylene oxide, and gamma radiation, but are often subject to bacterial infection. Microorganisms will form biofilms on the surface of implants or medical equipment, requiring high levels of antibiotics to inhibit bacteria, and the utilization rate is low. And the biofilm can also attract other bacteria and cause infection. Therefore, it is necessary to attach a coating with antibiotic drugs on the surface of the implant or medical device to kill bacteria or inhibit the growth of bacterial adhesion. [0003] Urethane acrylate, as a reactive oligomer, is a polyurethane with a double bond at the end, obtained by a two-step process from di- or polyisocyanate, diba...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/67C08G18/42A61L27/34A61L27/54A61L31/10A61L31/16
CPCC08G18/672A61L27/34A61L27/54A61L31/10A61L31/16A61L2300/406C08G18/4277C08G18/428C08G2230/00C08G18/42C08L75/14
Inventor 张嵘冯学鹏蒋晓菡
Owner CHANGZHOU UNIV
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