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A method for preparing non-toxic antibacterial coating on the surface of medical implant material

A technology for implanting materials and antibacterial coatings, applied in coatings, pharmaceutical formulations, medical science, etc., can solve problems such as increased cytotoxicity, achieve the effects of increasing cell proliferation, enhancing biomedical functions, and reducing cytotoxicity

Active Publication Date: 2019-07-19
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the introduction of Ag nanoparticles has the risk of increased cytotoxicity to a certain extent. How to maintain the antibacterial properties of the implant surface and greatly reduce or eliminate toxicity is a major challenge for the surface functionalization of medical biomaterials today, and urgent research is needed. solve

Method used

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  • A method for preparing non-toxic antibacterial coating on the surface of medical implant material
  • A method for preparing non-toxic antibacterial coating on the surface of medical implant material
  • A method for preparing non-toxic antibacterial coating on the surface of medical implant material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Nano-silver / Cyclone dipeptide composite films were prepared by pulse electrodeposition. The 10mm×10mm×2mm pure titanium plate was polished step by step with sandpaper to No. 1500, then ultrasonically cleaned with deionized water, acetone, ethanol and deionized water for 10 min respectively, and then dried. A 0.5% HF solution was prepared as the electrolyte, the polished titanium plate was used as the anode, and the large-area platinum electrode was used as the cathode to form a two-electrode electrolytic cell. The mechanical stirring of 200 r / min was applied to the system, the water bath was kept at a constant temperature, and the temperature of the system was controlled to be room temperature, about 25 °C. A regulated power supply was used to provide power to the electrolytic cell and electrochemical anodization was carried out under the condition of 20V constant voltage for 20min.

[0038] The electrolyte contains AgNO 3 0.01mol / L, NaNO 3 0.1mol / L, the concentratio...

Embodiment 2

[0040] The silver mirror reaction was used to prepare the nano-silver / proglutamate dipeptide composite film. The pretreatment method and electrochemical anodic oxidation treatment process of 10mm × 10mm × 2mm pure titanium plate are the same as those in Example 1. Now add 10 ml of silver ammonia solution, add 3 ml of 2 mol / L glucose solution, and the concentration of proglutamate dipeptide is 0.05 mol / L. The resulting titanium or titanium alloy is immersed in the solution, rinsed with deionized water after the reaction, and dried in the air. The anodized titanium or titanium alloy is immersed in the solution, rinsed with deionized water after the reaction, and dried in the air. The temperature is controlled at 25°C, and the reaction time is 20min. , to obtain a uniform distribution in TiO 2 The Ag nanoparticles in the mouth of the nanotube and in the tube, the particle size of the Ag nanoparticles is 30-60 nm (the present invention generally describes this morphology as morpho...

Embodiment 3

[0042] Nano-silver / Cyclone dipeptide composite film was prepared by ultraviolet light reduction method. The pretreatment method and electrochemical anodic oxidation treatment process of 10mm×10mm×2mm pure titanium plate are the same as in Example 1, and the preparation solution: AgNO-containing 3 1mol / L, the concentration of C-glutamate dipeptide is 0.05mol / L, the anodized titanium or titanium alloy is immersed in the solution, rinsed with deionized water, dried, soaked for 10min, taken out and placed in a mercury lamp (200W, 100mW / cm 2 ) under irradiation for 10 min, a uniform distribution of TiO particles can be obtained. 2 The Ag nanoparticles in the mouth of the nanotube and in the tube, the particle size of the Ag nanoparticles is 1-10 nm (the present invention generally describes this morphology as morphology three, such as image 3 shown). Adjusting the soaking time and soaking times can control the particle size of Ag nanoparticles to change within 1-30 nm, and the p...

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Abstract

The invention discloses a method for preparing a nontoxic antibacterial coating on the surface of a medical implant material and relates to a medical implant material. The invention provides the method for preparing the nontoxic antibacterial coating on the surface of the medical implant material, wherein the cytotoxicity of a silver composite membrane layer on the surface of an implant material can be remarkably reduced while excellent antibacterial property is maintained, and the method is mainly applied to the antibacterial modification of the implant surface in bone and tooth replacement and tissue regenerative medicine. The method comprises the following steps: pretreating the to-be-treated medical implant material; preparing a solution containing AgNO3, short peptide and electrolyte or reductive substance; and building a nano silver / short peptide composite membrane layer on the surface of the medical implant material. The cytotoxicity of the nano silver membrane layer on the surface of the implant material can be remarkably reduced while excellent antibacterial property is maintained. The method can be applied to the nontoxic antibacterial modification of the surfaces of multiple implants. The method is simple in technology, requires small investment and can be widely applied to the surface modification of medical implants while large-scale production can be realized.

Description

technical field [0001] The invention relates to medical implant materials, in particular to a method for preparing a non-toxic antibacterial coating on the surface of medical implant materials. Background technique [0002] In recent years, medical implant materials, including medical implants such as titanium and its alloys, stainless steel, ceramics and polymers, have been widely used in surgical implant materials, such as artificial joints, dental implants, vascular stents, bone plates Bone nails and other implants and medical devices. Bio-inorganic non-metallic composite materials and polymer materials are widely used in human soft and hard tissue restorations, artificial organs and so on. The antibacterial properties of medical implant materials are very important in the early stage of implantation. Nano-silver, as a broad-spectrum antibacterial agent, is introduced into the surface of medical implant materials, which can effectively improve the antibacterial propertie...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/28A61L27/54
CPCA61L27/28A61L27/306A61L27/54A61L2300/104A61L2300/252A61L2300/404A61L2300/606A61L2400/06
Inventor 林昌健宋然赵玉芬梁建鹤唐果杨云张艳梅高玉兴付川
Owner XIAMEN UNIV
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