Method for preparing high-purity phloretin by utilizing shaddock peels

Abstract

The invention discloses a method for preparing high-purity phloretin by utilizing shaddock peels. The method comprises the following steps: after crushing dried shaddock peels, extracting through water refluxing to obtain an extracting solution; adding an acid solution into the extracting solution, and carrying out an acid hydrolysis reaction; carrying out a hydrogenation reaction on a hydrolysis reaction product; acidifying and recrystallizing a hydrolysis reaction product in sequence to obtain the product. The method takes the shaddock peels as the direct raw material, so that the cost is low; the method has the advantages of simple process steps, high phloretin yield and high purity, and meets industrial production requirements.

Description

technical field [0001] The invention relates to a method for preparing high-purity phloretin from pomelo peel, which belongs to the field of separation and purification of natural medicines. Background technique [0002] [0003] Phloretin chemical name: 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone. Mainly distributed in the peel and root bark of juicy fruits such as apples and pears. Phloretin is a new type of natural skin whitening agent recently developed by foreign countries, and researches and develops new drugs by studying the relationship between compound structure and curative effect, and studies its mechanism of action and metabolic process in vivo. in progress. Studies have shown that phloretin has the following effects: [0004] (1) Anti-oxidation and anti-free radical effects: Phloretin has strong anti-oxidation properties, and the anti-oxidation concentration of oil is between 10 and 30ppm, which can remove free radicals in the skin, and free...

AI Technical Summary

Problems solved by technology

[0008] The content of phloretin in natural plants is scarce and the extraction rate is low, which limits the development and application of phloretin

Chinese patent (publication number CN103922914A) discloses a preparation method of high-purity phloretin, which specifically discloses that litchi peel is used as raw material, and litchi peel extract is prepared by heating with a high-purity, weakly polar solvent, and the obtained extract is subjected to liquid-liquid extraction. (including two-phase extraction), membrane technology separation and other separation and purification process steps to obtain high-purity phloretin. The process is complicated, the equipment required is expensive, and the yield of phloretin is low.

Chinese patent (publication number CN104292094A) discloses a preparation method of high-purity phloretin, which specifically discloses the steps of using apple root bark as a raw material, crushing, extraction, concentration, centrifugation, purification of macroporous adsorption resin, crystallization, acid hydrolysis, etc. , the phloretin produced industrially, the process is complicated, and the yield is low

Chinese patent (publication number CN103230408B) specifically discloses the use of naringin in the presence of lye and rare metal catalysts to carry out catalytic hydrogenation with hydrogen at medium pressure and normal temperature or under heating, and then collect naringin dihydrochalcone from the reaction system , then use naringin dihydrochalcone to heat and hydrolyze under the action of dilute acid, and purify to obtain phloretin. The initial raw material adopted in this method is naringin, and naringin itself is a kind of difficult compound to obtain, and its preparation method is loaded down with trivial details, The price is relatively expensive, which is not conducive to industrial application production

The steps for obtaining naringin or hesperidin in these methods are cumbersome and inefficient, resulting in limitations in the subsequent industrial production of phloretin

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