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Preparation method and application of porous core-shell double-metal organic framework nano drug carrier

A technology of organic framework and nano-drug loading, which is applied in preparations for in vivo experiments, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve problems such as complex methods of photothermal agents, cancer side effects, and cumbersome steps. Achieve excellent light-to-heat conversion ability and overcome poor water solubility

Active Publication Date: 2016-07-27
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the photothermal agent synthesized by this method is not only complicated in method and cumbersome in steps, but also has certain toxic and side effects in the treatment of cancer by doxorubicin.

Method used

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  • Preparation method and application of porous core-shell double-metal organic framework nano drug carrier
  • Preparation method and application of porous core-shell double-metal organic framework nano drug carrier
  • Preparation method and application of porous core-shell double-metal organic framework nano drug carrier

Examples

Experimental program
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Effect test

Embodiment 1

[0040]Dissolve 0.3g potassium ferricyanate and 1g polyvinylpyrrolidone in 80.0mL water, stir well, add 70μl hydrochloric acid solution with a mass concentration of 37% to make the pH value of the solution reach 2, and react at 60-90°C for 15-18h under airtight conditions , then cooled to room temperature, washed three times with ethanol and distilled water, and dried to obtain Prussian blue porous metal organic framework nanoparticles. Embodiment 2: the preparation of nano drug carrier

Embodiment 2

[0040]Dissolve 0.3g potassium ferricyanate and 1g polyvinylpyrrolidone in 80.0mL water, stir well, add 70μl hydrochloric acid solution with a mass concentration of 37% to make the pH value of the solution reach 2, and react at 60-90°C for 15-18h under airtight conditions , then cooled to room temperature, washed three times with ethanol and distilled water, and dried to obtain Prussian blue porous metal organic framework nanoparticles. Embodiment 2: the preparation of nano drug carrier

[0041] Place 25 mg of Prussian blue nanoparticles prepared in Example 1 in 7.5 mL of ferric chloride ethanol solution with a concentration of 3.5 mmol / L, and soak for 30 min at room temperature to allow the carbon layer to fully absorb ferric ions; centrifuge to remove the supernatant After that, add 7.5mL ethanol solution of trimesic acid with a concentration of 1.2mmol / L, react at 60°C for 30min, centrifuge to remove the supernatant after the reaction, repeat the above steps for coating 16 t...

Embodiment 3

[0043] Example 3: Loading of natural anticancer drug artemisinin

[0044] Disperse 5 mg of nano-drug carrier prepared in Example 2 in 1 mL of artemisinin-acetone solution with a concentration of 5 mg / mL, and after stirring for 30 min, add 6 mL of distilled water dropwise at a rate of 0.1-1 mL / min, and continue stirring until The acetone in the system was completely volatilized, and the stirring speed was 1000r / min. After the acetone was completely volatilized, it was washed with deionized water and centrifuged to remove unloaded artemisinin, and then vacuum-dried at 40°C for 6 hours to obtain drug-loaded particles. After the supernatant was collected, the drug loading was detected with an ultraviolet-visible spectrophotometer, and the loading was 848 mg / g, and the drug loading was detected with a Fourier transform infrared spectrometer (FT-IR).

[0045] According to the infrared spectrogram of present embodiment 3 products ( Figure 8 ), at 1737cm -1 and 800-1200cm -1 The p...

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Abstract

The invention discloses a preparation method and application of a porous core-shell double-metal organic framework nano drug carrier. The porous core-shell double-metal organic framework nano drug carrier takes a Prussian blue porous metal organic framework nano particle as a core, and an iron-containing porous metal organic framework MIL-100 covers the surface of a Prussian blue porous metal organic framework. The drug carrier disclosed by the invention can be used for carrying a natural drug artemisinin and the disadvantage that the water solubility of the artemisinin is poor is overcome; more artemisinin is delivered to tumor focus positions through intravenous infusion; after the artemisinin reaches the tumor positions, tumor cells are located in an acidic microenvironment, so that the iron-containing porous metal organic framework on the outer layer can be degraded and the carried artemisinin is released; meanwhile, under the irradiation of 808nm laser, the core Prussian blue nano particle can generate partial high heat for directly killing the tumor cells; finally, the synergistic anticancer effect combining artemisinin chemical therapy and Prussian blue photo-thermal therapy is realized.

Description

1. Technical field [0001] The invention relates to a preparation method and anti-tumor application of a porous core-shell bimetallic organic framework nano drug carrier. A core-shell porous nano particle is synthesized by a chemical method, which has the functions of fluorescence imaging and magnetic resonance imaging, and has It is pH-responsive, and can degrade and release the loaded artemisinin drug under acidic conditions to realize chemotherapy; at the same time, the core-shell nanoparticles have near-infrared photothermal conversion ability to realize photothermal therapy. Finally, the artemisinin-loaded nanoparticles integrate diagnosis, chemotherapy and photothermal therapy, and belong to the field of drug carriers. 2. Background technology [0002] Cancer is one of the greatest disease threats facing human beings. With the acceleration of global aging and the increase of behavioral activities related to carcinogenicity, the incidence of cancer continues to rise. Tr...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/51A61K47/02A61K31/366A61K49/00A61K49/06A61P35/00
CPCA61K9/5115A61K31/366A61K41/0052A61K49/0017A61K49/06A61K2300/00
Inventor 陈乾旺汪冬冬时若鸿陈汝慧
Owner UNIV OF SCI & TECH OF CHINA
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