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A kind of preparation method of medical chitosan temperature-sensitive hydrogel containing nano-silver

A temperature-sensitive hydrogel and chitosan technology, applied in medical science, bandages, etc., can solve the problems of preparation methods and applications that have not been reported, and achieve the effect of preventing wound infection, no cytotoxicity, and good wound infection

Active Publication Date: 2018-12-04
陕西美芙康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, the preparation method and application of medical chitosan thermosensitive hydrogel containing nano-silver using chitosan as carrier, dispersant and protective agent have not been reported.

Method used

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  • A kind of preparation method of medical chitosan temperature-sensitive hydrogel containing nano-silver
  • A kind of preparation method of medical chitosan temperature-sensitive hydrogel containing nano-silver
  • A kind of preparation method of medical chitosan temperature-sensitive hydrogel containing nano-silver

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Experimental program
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Effect test

Embodiment 1

[0038] Embodiment 1 A kind of preparation method of medical chitosan thermosensitive hydrogel containing nano-silver:

[0039](1) Grind chitosan (the chitosan used in this example was purchased from Zhejiang Aoxing Biotechnology Co., Ltd., Zhejiang) and silver nitrate into fine powders, and mix them. The mass ratio of chitosan to silver nitrate is 100:0.002 , fully and quickly ground for 1.5 hours, and irradiated with ultraviolet light for 4 hours to obtain chitosan nano-silver complex;

[0040] (2) dissolving the chitosan nano-silver complex obtained in step (1) with an aqueous solution of acetic acid with a concentration of 0.1mol / L, and preparing a chitosan nano-silver complex solution with a mass concentration of 1%;

[0041] (3) Add 56% sodium β-glycerophosphate solution to the chitosan nano-silver complex solution obtained in step (2),

[0042] The volume ratio of the chitosan nano-silver complex solution to the sodium β-glycerophosphate solution is 10:1, stir rapidly, ...

Embodiment 2

[0044] Embodiment 2 A kind of preparation method of the medical chitosan thermosensitive hydrogel containing nano-silver:

[0045] (1) Grind chitosan (the chitosan used in this example was purchased from Zhejiang Aoxing Biotechnology Co., Ltd., Zhejiang) and silver nitrate into fine powders, and mix them. The mass ratio of chitosan to silver nitrate is 100:0.1 , fully and quickly ground for 4 hours, and irradiated with ultraviolet light for 20 hours to obtain chitosan nano-silver complex;

[0046] (2) dissolving the chitosan nano-silver complex obtained in step (1) with an aqueous solution of acetic acid with a concentration of 0.25mol / L, and preparing a chitosan nano-silver complex solution with a mass concentration of 2.5%;

[0047] (3) Add 56% sodium β-glycerophosphate solution to the chitosan nano-silver complex solution obtained in step (2),

[0048] The volume ratio of the chitosan nano-silver complex solution to the sodium β-glycerophosphate solution is 10:3, stir rapi...

Embodiment 3

[0050] Embodiment 3 A kind of preparation method of the medical chitosan thermosensitive hydrogel containing nano-silver:

[0051] (1) Grind chitosan (purchased from Shandong Jiafeng Marine Biotechnology Co., Ltd.) and silver nitrate into fine powders respectively, mix them, the mass ratio of chitosan and silver nitrate is 100:0.005, fully and quickly grind for 1.8 hours, UV light irradiation for 6 hours to obtain chitosan nano-silver complex;

[0052] (2) dissolving the chitosan nano-silver complex obtained in step (1) with an aqueous solution of acetic acid with a concentration of 0.12mol / L, and preparing a chitosan nano-silver complex solution with a mass concentration of 1.5%;

[0053] (3) Add 56% sodium β-glycerophosphate solution to the chitosan nano-silver complex solution obtained in step (2),

[0054] The volume ratio of chitosan nano-silver complex solution to β-sodium glycerophosphate solution is 10:1.5, stir rapidly, add saturated disodium hydrogen phosphate buffe...

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Abstract

A preparing method of nano-silver containing medical chitosan thermosensitive hydrogel is disclosed. A product of the method is a novel medical material. The thermosensitive hydrogel has good bacteriostatic functions for Gram-negative bacteria represented by escherichia coli, Gram-positive bacteria represented by staphylococcus aureus and fungi represented by candida albicans, and is wide in bacteriostatic spectrum, free of cell toxicity, efficient and low in toxicity. After uniform spraying of the thermosensitive hydrogel, a gel film layer can be formed on the surface of a wound. The thermosensitive hydrogel is durable in bacteriostatic functions and good in gas permeability and hygroscopicity, has functions of promoting wound surface healing, arresting bleeding, arresting pain, reducing inflammation and sterilizing, can be used for burn, scald, trauma, and other large-area irregular wounds, is capable of rapidly arresting bleeding and pain, preventing infection and promoting wound healing, and can be used for bedsore, skin ulcer, tinea manus and pedis, woman colpitis, cervicitis, cervical erosion, and other skin inflammation diseases.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a preparation method of a medical chitosan temperature-sensitive hydrogel containing nano-silver. Background technique [0002] Chitosan is the only alkaline polysaccharide that exists in large quantities in nature, and it is a cationic polysaccharide formed after deacetylation of chitin. Chitosan is widely found in the shells of arthropods and the cell walls of fungi and yeasts. It is very rich in resources. It is also biodegradable, non-toxic, antibacterial, and has good biocompatibility. Deer antler glue-shell Glycan cell scaffolds can promote bone cell proliferation and activity, carboxymethyl chitosan can promote the proliferation and secretion of Schwann cells, and basement membrane matrix / chitosan can induce chondrogenic differentiation of bone marrow mesenchymal stem cells, etc. There are a large number of hydroxyl groups and amino groups on chitosan molecules, which are...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L5/08C08K3/08A61L26/00
CPCA61L26/0023A61L26/0066A61L26/0095A61L2300/104A61L2300/404C08J3/075C08K3/08C08K2003/0806C08K2201/011C08L5/08
Inventor 桑青秦东风崔凯李高青
Owner 陕西美芙康生物科技有限公司
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