Dental implant and surface preparation method thereof

A technology for dental implants and polydopamine, which is used in prostheses, medical science, pharmaceutical formulations, etc., can solve the problems of low bonding strength of modified coatings, improve surface hydrophilicity, improve stability and success rate, Simple preparation process

Inactive Publication Date: 2016-08-24
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to improve the biological activity of the surface of the existing dental implant and solve the shortcomings of the generally low bonding strength of the modified coating, the purpose of the present invention is to provide a dental implant and its biologically active surface treatment method to obtain a surface with Biomimetic properties Strongly adhere to dental implants with biological coatings, so that the surface of dental implants can obtain better hydrophilicity, protein adsorption and other capabilities, thereby improving the long-term stability and success rate of dental implants

Method used

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  • Dental implant and surface preparation method thereof
  • Dental implant and surface preparation method thereof
  • Dental implant and surface preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A dental implant, the surface of which is treated by:

[0022] (1) Select medical pure titanium as the substrate, and perform surface cleaning: successively undergo ultrasonic cleaning with acetone, absolute ethanol, and deionized water for 15 minutes, and then dry naturally;

[0023] (2) Configure dopamine self-polymerization precursor solution: use deionized water as solvent, configure 10mmol / L tris solution and 1mol / L hydrochloric acid solution, drop by drop into the configured tris solution Add hydrochloric acid solution until the pH value is adjusted to 8.5; use the obtained Tris buffer as a solvent, and prepare a 2 mg / ml dopamine hydrochloride solution;

[0024] (3) The dental implant treated in step (1) was vertically and completely immersed in the dopamine hydrochloride solution prepared in step (2), and the solution was magnetically stirred and soaked in an oxygen-filled environment for 12 hours, then rinsed in deionized water, and naturally After drying, the ...

Embodiment 2

[0033] A dental implant, the surface of which is treated by:

[0034] (1) Select medical pure titanium as the substrate, and perform surface cleaning: successively undergo ultrasonic cleaning with acetone, absolute ethanol, and deionized water for 15 minutes, and then dry naturally;

[0035](2) Configure dopamine self-polymerization precursor solution: use deionized water as solvent, configure 10mmol / L tris solution and 1mol / L hydrochloric acid solution, drop by drop into the configured tris solution Add hydrochloric acid solution until the pH value is adjusted to 8.5; use the obtained Tris buffer as a solvent, and prepare a 1.5 mg / ml dopamine hydrochloride solution;

[0036] (3) The dental implant treated in step (1) was vertically and completely immersed in the dopamine hydrochloride solution prepared in step (2), and the solution was magnetically stirred and soaked in an oxygen-filled environment for 12 hours, then rinsed in deionized water, and naturally After drying, the...

Embodiment 3

[0038] A dental implant, the surface of which is treated by:

[0039] (1) Select medical pure titanium as the substrate, and perform surface cleaning: successively undergo ultrasonic cleaning with acetone, absolute ethanol, and deionized water for 15 minutes, and then dry naturally;

[0040] (2) Configure dopamine self-polymerization precursor solution: use deionized water as solvent, configure 10mmol / L tris solution and 1mol / L hydrochloric acid solution, drop by drop into the configured tris solution Add hydrochloric acid solution until the pH value is adjusted to 8.5; use the obtained Tris buffer as a solvent, and prepare a 1.5 mg / ml dopamine hydrochloride solution;

[0041] (3) The dental implant treated in step (1) was vertically and completely immersed in the dopamine hydrochloride solution prepared in step (2), and the solution was magnetically stirred and soaked in an oxygen-filled environment for 18 hours, then rinsed in deionized water, and naturally After drying, th...

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Abstract

The present invention relates to a dental implant and its surface preparation method. The dental implant uses medical titanium or titanium alloy as the base material, self-polymerizes on its surface in situ to form a strongly adherent polydopamine biomimetic coating, and obtains a Dental implant surfaces with excellent bioactivity. The present invention tightly adheres a thin layer of protein analogue (polydopamine) on the surface of the implant, which can improve surface hydrophilicity and corrosion resistance, and effectively strengthen the adhesion and spreading of osteoblasts on the surface of the implant, and improve the alkaline Phosphatase activity speeds up the early osseointegration of implants, realizes the firm combination of materials and biological interfaces, thereby improving the stability and success rate of implants.

Description

technical field [0001] The invention relates to the field of dental implant materials, in particular to a dental implant and a bioactive surface treatment method thereof. Background technique [0002] Oral implant materials refer to biomaterials that are implanted into the oral and maxillofacial tissues to replace missing teeth, defective bone tissue, and correction of bone tissue deformities, so as to restore the patient's physiological shape and function. When the implant is implanted in the human body, the physical and chemical properties and surface structure of the material surface will significantly affect the adhesion, extension, growth, proliferation, and cell activity and orientation of cells. Titanium and titanium alloys have good mechanical properties and certain biocompatibility, which makes them widely used in clinical practice. However, titanium is a biologically inert material, and it still does not have biological functions. After long-term service in the bod...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/06A61L27/50
CPCA61L27/34A61L27/06A61L27/50A61L2400/18A61L2420/02A61L2430/12C08L79/02
Inventor 董超芳章彦娴王喆肖葵张达威李晓刚杨瑟飞
Owner UNIV OF SCI & TECH BEIJING
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