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High-toughness active bone repair material and preparation method thereof

A technology of bone repair and high toughness, applied in the field of medical materials, can solve the problems of prolonging the clinical treatment time of bone repair, poor matching of bone tissue growth speed, and low fracture toughness, so as to shorten the treatment time, improve osteogenic activity and mechanical strength Improved effect

Active Publication Date: 2016-09-21
吴雨潞
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, compared with the human body's own bone tissue, hydroxyapatite bone repair materials still have low strength, low fracture toughness, and high elastic modulus, so they can only be used as bone filling materials or in non-load-bearing applications. In addition, the degradation rate of hydroxyapatite bone repair materials is still relatively slow, and the matching with the growth rate of bone tissue is poor, which prolongs the clinical treatment time of bone repair and limits its application to a certain extent.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A high-toughness active bone repair material, comprising the following components in parts by weight: 10 parts of inorganic calcium salt, 10 parts of inorganic phosphate, 0.3 part of strontium carbonate, 0.5 part of magnesium sulfate, 0.1 part of cerium nitrate, and 0.7 part of cobalt nitrate 3 parts, 3 parts of lanthanum chloride, 2 parts of graphene, 0.4 part of potassium oxalate, 0.5 part of lysine, 0.2 part of cysteine, 2 parts of polyvinylpyrrolidone; Ca / in the described inorganic calcium salt and inorganic phosphate The molar ratio of the total substance of P is 1.0; the inorganic phosphate includes sodium polyphosphate and sodium pyrophosphate.

[0024] The inorganic calcium salt is calcium chloride, calcium hydroxide, and calcium nitrate in a material ratio of 3:1:2.

[0025] The inorganic phosphate is sodium polyphosphate and sodium pyrophosphate in a ratio of 4:1.

[0026] The preparation method of the high-toughness active bone repair material, the preparat...

Embodiment 2

[0032] A high-toughness active bone repair material, comprising the following components in parts by weight: 12 parts of inorganic calcium salt, 22 parts of inorganic phosphate, 0.9 part of strontium carbonate, 0.7 part of magnesium sulfate, 0.4 part of cerium nitrate, 1.3 parts of cobalt nitrate parts, 5 parts of lanthanum chloride, 3 parts of graphene, 0.8 parts of potassium oxalate, 1 part of lysine, 0.4 parts of cysteine, 4.5 parts of polyvinylpyrrolidone; the Ca / The molar ratio of the total substance of P is 1.8; the inorganic phosphate includes sodium polyphosphate and sodium pyrophosphate.

[0033] The inorganic calcium salt is calcium chloride, calcium nitrate tetrahydrate, and calcium chloride dihydrate in a material ratio of 2:1:4.

[0034] The inorganic phosphate is sodium polyphosphate and sodium pyrophosphate in a ratio of 5:2.

[0035] The preparation method of the high-toughness active bone repair material, the preparation steps are:

[0036] 1) Dissolve stro...

Embodiment 3

[0041] A high-toughness active bone repair material, comprising the following components in parts by weight: 14 parts of inorganic calcium salt, 35 parts of inorganic phosphate, 1.5 parts of strontium carbonate, 1 part of magnesium sulfate, 0.8 part of cerium nitrate, and 2 parts of cobalt nitrate 8 parts, 8 parts of lanthanum chloride, 4 parts of graphene, 1.2 parts of potassium oxalate, 1.6 parts of lysine, 0.7 parts of cysteine, 7 parts of polyvinylpyrrolidone; Ca / The molar ratio of the total substance of P is 2.5; the inorganic phosphate includes sodium polyphosphate and sodium pyrophosphate.

[0042] The inorganic calcium salt is calcium nitrate, calcium nitrate tetrahydrate and calcium chloride dihydrate in a ratio of 3:2:1.

[0043] The inorganic phosphate is sodium polyphosphate and sodium pyrophosphate in a ratio of 2:5.

[0044] The preparation method of the high-toughness active bone repair material, the preparation steps are:

[0045] 1) Dissolve strontium carbona...

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Abstract

The invention discloses a high-toughness active bone repair material and a preparation method thereof. The active bone repair material comprises the following components: inorganic calcium salt, inorganic phosphate, strontium carbonate, magnesium sulfate, cerium nitrate, cobalt nitrate, lanthanum chloride, graphene, potassium oxalate, lysine, cysteine and polyvinylpyrrolidone. The C / P total mole ratio in the inorganic calcium salt and inorganic phosphate is 1.0-2.5. The inorganic phosphate comprises sodium polyphosphate and sodium pyrophosphate. The bone repair material has the advantages of obviously higher mechanical strength, favorable compression strength, favorable toughness and high porosity (higher than 65%), is beneficial to adhesion and proliferation of human body bone cells, promotes rapid formation of new bones, promotes new bone tissues to grow into pores, enhances the osteogenesis activity of the material, is capable of increasing the bone repair rate and shortening the treatment time, and thus, has favorable application value.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a high-toughness active bone repair material and a preparation method thereof. Background technique [0002] With the rapid development of the economy, bone defects caused by traffic accidents, industrial injuries, various diseases and trauma are becoming more and more frequent, which has increased people's attention to bone repair. At present, autologous bone or allogeneic bone is mainly used for bone repair clinically. However, the source of autologous bone and natural bone is limited. At the same time, there are also problems such as rejection of allogeneic bone, complications in the repair area, and long repair and fusion time. Therefore, There is an urgent need for a new type of artificial bone repair material to solve the above problems. [0003] Hydroxyapatite is the main inorganic component of human bones and teeth. Because of its good biocompatibil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/447C04B35/622C04B38/00A61L27/50A61L27/56
CPCA61L27/50A61L27/56C04B35/447C04B35/622C04B38/0022C04B2235/442C04B2235/443C04B2235/444C04B2235/448C04B2235/5248C04B2235/602C04B2235/74C04B38/0074
Inventor 林春梅
Owner 吴雨潞