Huperzine A production method suitable for industrial production

Abstract

The invention provides a huperzine A production method suitable for industrial production and relates to a huperzine A production method. The huperzine A production method comprises the following specific steps of pretreatment of raw materials, extraction, centrifugation, ultra-filtration, nano-filtration, PH value regulation, concentration, microwave drying and smashing. The huperzine A production method adopts a membrane technology for separation and purification. Compared with other purification modes such as macroporous resin adsorption and solvent extraction, the huperzine A production method has the advantages of being safe, environmentally friendly and capable of saving energy, only using a pure water solvent, not adopting an organic solvent and the like, the operation is simple, the product is safe, environmentally friendly, good and inexpensive, and continuous large-scale industrial production can be achieved.

Description

technical field [0001] The invention relates to a production method of huperzine A, in particular to a method suitable for industrial production of high-purity huperzine A. Background technique [0002] Huperzine A is used for middle-aged and elderly people with benign memory impairment and various types of dementia, memory cognitive function and emotional behavior disorders. Can still be used to treat myasthenia gravis. Its Chinese aliases are: Fordine, Haberin, Zhulin Ante. This product is a reversible cholinesterase inhibitor, which has a selective inhibitory effect on true cholinesterase and has high biological activity. [0003] At present, there are more and more diseases such as benign memory impairment and various types of dementia, memory cognitive function and emotional behavior disorders in middle-aged and elderly people, and the demand for this product is also increasing. At present, huperzine A has a good therapeutic effect on this type of disease in the worl...

AI Technical Summary

Problems solved by technology

At present, huperzine A has a good therapeutic effect on this type of disease in the world, and there are many pharmacological and toxicological studies on huperzine A abroad, but there is almost no separation and purification of huperzine A. For the purification and separation of huperzine A, solvent extraction is more used for separation, and there are more solvent residues, which affect the curative effect

[0004] CN 102617469A discloses a method for extracting huperzine A of Melaleuca, which comprises pulverizing the medicinal material of Melaleuca, ultrasonically extracting with acid solution, concentrating, adjusting pH with ammonia water, extracting with chloroform, dissolving acid solution again, and filtering with activated carbon for impurity removal , secondary ammonia water to adjust the pH value, chloroform extraction again, crystallization and recrystallization, and finally the product is dried. The purity of huperzine A in the product reaches 99%, and the yield of huperzine A is about 0.016%. Due to the process of repeated extraction , large loss, low yield and high cost

CN101693689A discloses a new method for extracting and separating high-purity huperzine A from the Melaleuca Tower. The method is to properly pulverize the medicinal material of the Melaleuca Tower, extract it with acid water, adjust the pH with ammonia water, absorb and separate the macroporous resin, and high-speed countercurrent Chromatographic purification, concentration and drying to obtain the finished product, the purity of huperzine A in the finished product can reach more than 98%, but in the process of this method, the investment of high-speed countercurrent chromatography equipment is large and the processing capacity is limited, so it is difficult to adapt to industrial production

CN 101602727A discloses a preparation method of huperzine A. The method is to use acid liquid to extract the coarse powder of the melaleuca tower, and prepare huperzine A with a purity of 90% through ion exchange, macroporous resin adsorption separation, crystallization and recrystallization. % more than the product, although the technique of this method is simple, operability is strong, but yield is unsatisfactory

CN102491946 A discloses a method for separating and purifying huperzine A by molecular imprinting technology. In this method, ultrasonic countercurrent extraction is carried out on the melaleuca medicinal material, and after concentration and decolorization, molecular imprinting polymerization, crystallization and recrystallization can prepare huperzine A with a purity of 99%. For the above products, the inventive method directly carries out ultrasonic countercurrent extraction of medicinal materials. Since the content of active ingredients in the Melaleuca tower is extremely low, there are many impurities extracted, which hinders the transfer of active substances in the solvent to a certain extent and affects the extraction yield of huperzine A. , which is unfavorable to the purification of subsequent processes; in addition, the molecular imprinting technology used in this method has high operability requirements, complicated control, and immature technology, which is only suitable for small batch production and is not conducive to scale-up and industrial production.