A nano-silica composite hydrogel for 3D printing and wound repair

A nano-silica and composite hydrogel technology, applied in biochemical equipment and methods, prostheses, drug delivery, etc., can solve the problems of poor optical transparency, low speed, high brittleness, etc., and achieve high toughness and gelation Fast, moderate viscosity and hardness

Active Publication Date: 2019-11-05
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the water absorption characteristics and mechanical properties of the hydrogel can be changed by adjusting the degree of chemical crosslinking, the chemically crosslinked polymer hydrogel has disadvantages such as poor optical transparency, low water absorption (dehydration) rate, low strength, and high brittleness. , so it is greatly limited in application

Method used

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  • A nano-silica composite hydrogel for 3D printing and wound repair
  • A nano-silica composite hydrogel for 3D printing and wound repair
  • A nano-silica composite hydrogel for 3D printing and wound repair

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Embodiment 1

[0032] Such as figure 1 Schematic diagram of nano-silica composite hydrogel structure and figure 2 The schematic diagram of the preparation of nano-silica composite hydrogel is shown as follows:

[0033] A method for preparing a nano-silica composite hydrogel that can be used for 3D printing and wound repair such as:

[0034] (1) Synthesis of nanocomposite particles: Add 2.8mL tetraethyl orthosilicate dropwise to 147mL absolute ethanol under stirring, then add 3mL deionized water and 7.5mL 28% ammonia water, mix well and place in a water bath at 40°C Medium reflux for 8h. Subsequently, 1 mL of silane coupling agent KH590 was added to the mixed solution, refluxed in a water bath at 40°C for 8 hours, and then the mixed solution was centrifuged and washed twice to obtain silica nanoparticles with mercapto groups at the end, and the centrifuged nanoparticles were Disperse in 15mL Tris-HCl (PH=7.2), add 20mg dithiothreitol (DTT) and stir for 1h, the purpose is to open the disul...

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Abstract

The invention relates to a nano-silicon dioxide composite hydrogel for 3D printing and wound repair, and belongs to a polymeric biomaterial. Nano-silicon dioxide of which the tail end is connected with a beta-dihydroxy compound serves as an initiating agent and a cross-linking agent, gelatin of which the tail end is connected with a double bond serves as a monomer, nano-silicon dioxide and the gelatin are uniformly dispersed in an aqueous solution, and the nano-silicon dioxide composite hydrogel is prepared through enzymatic-catalysis free radical polymerization under the action of glucose and glucose oxidase. The hydrogel can be prepared at room temperature within 6 min to 30 min by adjusting the concentrations of nano-silicon dioxide with the beta-dihydroxy compound, glucose and glucose oxidase. The hydrogel has the advantages of being mild, efficient, good in mechanical property and high in biocompatibility, therefore, the hydrogel can be used for 3D printing and cell culture, and the hydrogel can be used for tissue engineering of wound repair and the like after being loaded with fibroblast growth factors.

Description

technical field [0001] The invention belongs to the technical field of polymer biomaterials, and specifically refers to a nano-silica composite hydrogel that can be used for 3D printing and wound repair. The hydrogel has biological activity and multifunctionality, and can be used as a carrier of growth factors and cells, and can be applied to the treatment of wound repair. Background technique [0002] Hydrogels are gels in which water is the dispersion medium. A part of hydrophobic groups and hydrophilic residues are introduced into the water-soluble polymer with a network cross-linked structure. joint polymer. It is a polymer network system, which is soft in nature, can maintain a certain shape, and can absorb a large amount of water. [0003] The usual hydrogel is composed of chemically cross-linked polyelectrolyte such as polyacrylamide or polyacrylic acid network, because the fracture energy is usually 10-100J / m2, so its century application range is greatly reduced. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P21/00A61L27/24A61L27/02A61L27/52A61L27/54A61L27/56A61L27/50A61L27/58B29C67/00B33Y40/00
CPCA61L27/025A61L27/24A61L27/50A61L27/52A61L27/54A61L27/56A61L27/58A61L2300/252A61L2300/412A61L2300/414A61L2300/604A61L2400/06B33Y40/00C12N5/00C12N2533/54C12P21/00
Inventor 吕雅楠王启刚胡文
Owner TONGJI UNIV
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