The invention discloses a high-yield cultivation method of scutellaria baicalensis. The method specifically comprises the following steps: step 1, land preparation; step 2, winter treatment of big ridges; step 3, winter treatment of seedling filling land; step 4, seed treatment of scutellaria baicalensis; step 5, sowing pretreatment of the big ridges and the seedling filling land; step 6, sowing in the seedling filling land; step 7, sowing of big ridge land; step 8, initial seedling management; step 9, secondary earthing up; step 10, intermediate management; step 11, flow bud removal: flower buds are directly removed when scutellaria baicalensis seedlings come forth buds. According to the high-yield cultivation method of scutellaria baicalensis, a deep frozen soil ploughing manner is adopted to remove insect pests, meanwhile, the land looseness is improved, a multi-channel nesting manner is adopted, a growing environment with loose soil and long fertilizer efficiency period can be provided for the scutellaria baicalensis, external grass covering and secondary earthing up manners are adopted, water lack or water accumulation at roots can be avoided, and the growth vigor and later yield of the scutellaria baicalensis can be guaranteed.