A kind of preparation method of 7-methoxyflavone

A technology of methoxyflavone and benzoyl chloride, which is applied in the field of preparation of 7-methoxyflavone, can solve the problems of reduced product yield, complicated preparation process, loss, etc., and achieves simple operation, easy industrial production, and short route Effect
CN106083793BInactive Publication Date: 2018-04-10JIAXING UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JIAXING UNIV
Publication Date
2018-04-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a preparation method of 7-methoxyflavone and belongs to the field of chemical synthesis. The preparation method comprises that paeonol and benzoyl chloride as raw materials undergo an esterification reaction in the presence of triethylamine base, then the reaction mixed solution is subjected to simple suction filtration so that triethylamine hydrochloride is removed, potassium tert-butoxide is directly added into the filtrate, the mixture undergoes a reaction at the normal temperature, dibutyltin oxide is added into the reaction product, and the formed reaction mixed solution is subjected to heating backflow dehydration so that 7-methoxyflavone is obtained. The technical route has the characteristics of less process, operation simpleness, no pollution, desiccant reuse and industrial production easiness. The preparation method is an economic and simple 7-methoxyflavone preparation method.
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Description

technical field

[0001] The invention belongs to the field of chemical synthesis, and more specifically relates to a preparation method of 7-methoxyflavone. Background technique

[0002] 7-methoxyflavone is a kind of flavonoids with strong biological activity, which has the functions of preventing and treating diabetes, anti-cancer, anti-inflammation, anti-oxidation, anti-mutagenesis and cardiovascular. Because natural 7-methoxyflavone compounds are limited by natural content, and there are certain difficulties in separation and purification. Therefore, the research on the chemical synthesis of 7-methoxyflavone has important practical significance.

[0003] The reported methods for the synthesis of 7-methoxyflavone mainly use the Baker-Venkataraman method, Rries rearrangement, iodine catalysis, solid-phase supported catalysis, microwave-assisted synthesis, and organic base DBU catalyzed cyclization, etc., but these methods all exist The shortcomings of long route, low total...

Claims

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