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A kind of biological patch and preparation method

A biological patch and patch technology, applied in the field of medical devices, can solve the problems of long peritoneal time, expensive process, easy to cause adhesion, etc., and achieve the effects of increasing surface area, simple process, and enhancing cell adhesion performance.

Active Publication Date: 2019-11-15
CHANGZHOU CONDINER MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the natural polymer materials mentioned in this technique, such as hyaluronic acid, chitosan, etc., degrade too quickly, and the regeneration of the peritoneum takes longer
Other natural polymer materials mentioned, such as collagen and gelatin, usually become very hard after drying and heat pressing, which can easily cause tissue scratches and cause foreign body sensation
[0006] In addition, the above-mentioned patch products also have the problems of introducing toxic substances due to chemical reactions, because the existing patches are easy to delaminate, have poor flexibility and easily cause adhesion, and the preparation process is relatively expensive.

Method used

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  • A kind of biological patch and preparation method
  • A kind of biological patch and preparation method
  • A kind of biological patch and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Preparation of bio-patch

[0038] 1. Dissolving collagen extracted from bovine Achilles tendon in hexafluoroisopropanol to obtain a collagen solution with a concentration of 5 wt %;

[0039] 2. Place the polypropylene (PP) mesh in a collagen solution with a concentration of 5wt%, and freeze-dry it to obtain a collagen-polypropylene membrane;

[0040] 3. PLA-PCL copolymer (70% PLA, 30% PCL copolymer) is dissolved in acetone and made concentration is the polymer solution of 10wt%;

[0041] 4. Immerse the collagen-polypropylene membrane in the PLA-PCL copolymer acetone solution, so that the PLA-PCL copolymer acetone solution enters the pores of the collagen-polypropylene membrane, and use a low-temperature decompression process to obtain anti-adhesion regeneration after drying biological patch;

[0042] 5. Carry out radiation sterilization to the obtained biological patch.

[0043] The biologically extracted collagen used in this example is derived from extracts of pig ...

Embodiment 2

[0045] 1. Dissolving biologically extracted collagen in dioxane to obtain a collagen solution with a concentration of 5wt%;

[0046] 2. Put the polypropylene (PP) mesh into the collagen solution, and freeze-dry to obtain the collagen-PP membrane;

[0047] 3. What is the concentration of PHB dissolved in ethyl acetate? wt% polymer solution;

[0048] 4. Immerse the collagen-PP membrane in the PLCL solution but not completely, let the PHB solution enter the pores of the collagen-PP membrane, adopt a low-temperature decompression process, and dry to obtain an anti-adhesion regenerative biological patch;

[0049] 5. Carry out radiation sterilization to the obtained biological patch.

[0050] The biologically extracted collagen used in this example is skin collagen, which is derived from pig skin. The layers of the patch prepared in this example are well bonded, cut without delamination, soaked in 37°C physiological saline solution for 24 hours without delamination, and very soft. ...

Embodiment 3

[0052] 1. Dissolving the biologically extracted collagen in DMSO to obtain a collagen solution with a concentration of 5wt%;

[0053] 2. Put the polypropylene (PP) mesh into the collagen solution, and freeze-dry to obtain the collagen-PP membrane;

[0054] 3. What is the concentration of dissolving PLA in ethanol? wt% polymer solution;

[0055] 4. Immerse the collagen-PP membrane in the PLA solution, but not completely, so that the PLA solution enters the pores of the collagen-PP membrane, adopt a low-temperature decompression process, and dry to obtain an anti-adhesion regenerative biological patch;

[0056] 5. Carry out radiation sterilization to the obtained biological patch.

[0057] The biologically extracted collagen used in this example is collagen, which is derived from bovine bone. The layers of the patch prepared in this example are well bonded, cut without delamination, soaked in 37°C physiological saline solution for 24 hours without delamination, and very soft....

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Abstract

The invention discloses a biological repair sheet. The biological repair sheet comprises a middle layer providing a mechanical support for the biological repair sheet, an anti-adhesion layer which is connected to the middle layer, is located at one side of the middle layer and is used for preventing tissue and organ adhesion, and a biological regeneration material layer which is connected to the middle layer, is located at the other side of the middle layer and is used for promoting soft tissue regeneration and inhibiting scars. The invention also discloses a preparation method of the biological repair sheet. The biological repair sheet has physical inlaying effects so that all the layers of the biological repair sheet are bonded tightly and are difficultly separated, the last step of hot pressing for strengthening is avoided and heating-caused biodegradable polyester material degradation is avoided. A sponge structure is formed through a freeze-drying technology so that the biological repair sheet is soft. The biological repair sheet has good softness.

Description

technical field [0001] The invention relates to implant materials in the field of medical instruments. More specifically, it relates to a biological patch and a preparation method thereof. Background technique [0002] At present, biological meshes are used in many surgical operations, especially hernia meshes and pelvic floor meshes are the most widely used. The purpose of using meshes is to reinforce and bridge damaged or weak soft tissues. Biological patches are currently used more maturely, with ePTFE as the raw material of puffed patch, and PP as the raw material of the patch woven by spinning. These two kinds of patches have been used clinically for many years. However, after a long period of clinical use, some disadvantages of the two types of patches have gradually emerged. First, due to poor flexibility, the foreign body sensation after implantation in the human body is strong. Secondly, due to the difference in mechanical compliance between the body and the surrou...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/12A61L31/06A61L31/04A61L31/14
CPCA61L31/044A61L31/048A61L31/06A61L31/146C08L89/00C08L67/04C08L23/12
Inventor 陈小菊承建荣王盛束秋红葛妮娜
Owner CHANGZHOU CONDINER MEDICAL TECH
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