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Compound drug carrier for multi-response mechanism and preparation method thereof

A drug and carrier technology, which is applied in the field of multi-response mechanism compound drug carrier and its preparation, can solve the problems of drug waste and other problems, and achieve the effect of easy operation, simple process and less damage

Active Publication Date: 2017-01-18
UNIV OF SCI & TECH BEIJING
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The present invention aims to solve the problem of drug waste in the administration process of traditional drugs, and synthesizes a multi-response mechanism polymer-wrapped FePt nanocomposite drug carrier, which is made of polymer-wrapped FePt nanometers, wherein the polymer includes isopropyl propylene Amide (NIPAM), Acrylamide (AA)

Method used

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  • Compound drug carrier for multi-response mechanism and preparation method thereof
  • Compound drug carrier for multi-response mechanism and preparation method thereof
  • Compound drug carrier for multi-response mechanism and preparation method thereof

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preparation example Construction

[0025] The invention relates to a multi-response mechanism polymer-wrapped FePt nanocomposite drug carrier and a preparation method thereof, which is characterized in that it has three response mechanisms of thermal response, magnetic response and pH response. The preparation of composite drug carrier is specifically carried out according to the following steps:

[0026] 1. Preparation of FePt nanoparticles: solid Pt(acac) is housed in a three-necked flask 2 and Fe(acac) 3 , add oleylamine and 1,6-hexadecanediol, mix and stir, and place in a protective atmosphere; the solution is purified at room temperature, and then slowly heated to 100 ° C ~ 120 ° C in a protective atmosphere; add oleic acid, and maintain the temperature; then raise the temperature to 280°C to 300°C, and maintain the temperature; finally, slowly cool the solution to room temperature, and magnetically separate the precipitate in the solution;

[0027] 2. Preparation of FePt nanoparticles functionalized wit...

Embodiment 1

[0032] 1. Preparation of FePt nanoparticles: Add 0.5mmol solid Pt(acac) in a three-necked flask 2 and 0.5mol of Fe(acac) 3 Add 10ml of oleylamine and 0.16ml of oleic acid, mix and stir, and place in a protective atmosphere of nitrogen. The solution was purified at room temperature for 0.5h, then slowly heated to 110°C in a protective atmosphere and kept for 0.5h; oleic acid was added to the flask and kept at the temperature; then the temperature was raised to 290°C and kept for 0.5h; finally, the solution was Slowly cool to room temperature, and magnetically separate the precipitate in the solution;

[0033] 2. Preparation of FePt nanoparticles functionalized with ammonia radicals: Dissolve 20 mg of the solid FePt prepared in 1 in ethanol, oscillate with ultrasonic waves, then add 60 mg of 2-aminoethanethiol (2-Aminoethanethiol) and mix magnetically at room temperature for 24 hours , and finally magnetic separation and washing;

[0034] 3. Preparation of carbon-carbon doubl...

Embodiment 2

[0038] 1. Preparation of FePt nanoparticles: Solid Pt(acac) in a three-necked flask 2 0.5mmol, Fe(acac) 3 0.5mol, add 10ml oleylamine and 0.16ml oleic acid, mix and stir, and place in a protective atmosphere; the solution is purified at room temperature for 0.5h, and then slowly heated to 110°C in a protective atmosphere for 0.5h; Add oleic acid and keep the temperature; then raise the temperature to 290°C and keep it for 0.5h; finally, slowly cool the solution to room temperature, and magnetically separate the precipitate in the solution;

[0039] 2. Preparation of FePt nanoparticles functionalized with ammonia radicals: Dissolve 20 mg of the solid FePt prepared in 1 in ethanol, oscillate with ultrasonic waves, then add 60 mg of 2-aminoethanethiol (2-Aminoethanethiol) and mix magnetically at room temperature for 24 hours , and finally magnetic separation and washing;

[0040] 3. Preparation of carbon-carbon double bonds on FePt nanoparticles modification: the synthesized Fe...

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Abstract

The invention relates to a compound drug carrier for multi-response mechanism and preparation method thereof. The compound drug carrier achieves three types of response mechanisms, exogenous stimulus magnetic fields, heat and endogenous stimulus pH, to regulate drug target release. The present invention provides a method to control drugs to release fixed concentration quantity drug in the target area within certain time. The method solves the problem of drug or medicine waste arising from traditional methods. The present invention alters the lowest solution temperature of polymer liquids through regulating the structure of molecular entity in the syntheses process of polymers. Through altering the temperature, the method regulates the physical characteristics of nanometer drug carrier to control the release of drug targets. FePt nanometer granule wrapped by polymers alters the polymer temperature through regulating the magnetic fields to cause the polymer to have phase transformation, to achieve the purpose of controlling drug releases. The nanometer carrier has superior cell compatibility, high cell intake rate and low cell toxic, and has wide application prospect in regulating the release of drug target and treating cancer diseases.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a multi-response mechanism composite drug carrier and a preparation method thereof. Background technique [0002] With the continuous miniaturization of material systems, nanotechnology has become an indispensable and important element in various fields, and has achieved amazing results in the practical application of many technologies. Nanomaterials (such as metals, metal oxides, carbon materials, and semiconductor materials) exhibit novel physical, chemical, and biological properties due to their structure and composition, and have been widely used in catalysis, separation, sensors, optics, energy, and electronics. and other fields. With the rapid development of nanotechnology, nanomedicine (nanomedicine) gradually shows strong vitality. In addition, it is also an emerging discipline formed by combining nanotechnology with the fields of chemistry, biology, medi...

Claims

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Application Information

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IPC IPC(8): A61K47/34A61K47/02
Inventor 张跃彭玉山廖庆亮
Owner UNIV OF SCI & TECH BEIJING
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