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Zwitterionic random copolymer surface modification coating with epoxy functional group, preparation method and application

A technology of random copolymers and epoxy functional groups, which can be used in coatings, drug delivery, and pharmaceutical formulations. It can solve the problems of weakened anticoagulant performance, achieve simple preparation technology, mild preparation conditions, and improve biocompatibility Effects on blood compatibility

Active Publication Date: 2019-06-21
天津渤化讯创科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method can only temporarily improve its blood compatibility. With the loss of surface heparin, the anticoagulant properties of PVC are gradually weakened. However, there are few reports on the fixation of zwitterionic materials to the surface of PVC.

Method used

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  • Zwitterionic random copolymer surface modification coating with epoxy functional group, preparation method and application
  • Zwitterionic random copolymer surface modification coating with epoxy functional group, preparation method and application
  • Zwitterionic random copolymer surface modification coating with epoxy functional group, preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0027] Preparation of poly(SA-TMA-GMA) coating on the surface of polyvinyl chloride (PVC) film

[0028]First, the PVC membrane was cleaned with ethanol aqueous solution for 30 min in an ultrasonic cleaner and dried in a nitrogen stream.

[0029] Then, add ethylenediamine aqueous solution with a concentration of 70% into the reaction bottle, and then quickly immerse the PVC film in the ethylenediamine aqueous solution, and react at 80° C. for 1 hour. After the reaction, wash the surface of PVC with a large amount of deionized water to remove unreacted ethylenediamine molecules on the surface, then dry it with nitrogen flow, and finally put the film in a vacuum drying oven and dry it to constant weight at room temperature to obtain PVC- NH 2 . The concentration of ethylenediamine aqueous solution, reaction temperature and time can be adjusted as required.

[0030] Finally, the surface-aminated PVC membrane was immersed in 10 mg / mL poly(SA-TMA-GMA) terpolymer STG1 in PBS buffe...

Embodiment 2～4

[0046] By the method of embodiment 1, the difference is that other composition poly(SA-TMA-GMA) ternary random copolymers are used instead of STG1 to modify the surface coating, as shown in Table 2 and image 3 .

Embodiment 5

[0048] According to the method of Example 10, a PVC pipe of 1 m was cleaned with ethanol aqueous solution for 30 min in an ultrasonic cleaner, and dried in a nitrogen stream. Then, a section of the PVC pipe was sealed, and a 70% aqueous solution of ethylenediamine was added into the pipe, and reacted at 80° C. for 1 h. After the reaction, rinse the PVC tube with a large amount of deionized water to remove unreacted ethylenediamine molecules on the surface, and then inject 10 mg / mL poly(SA-TMA-GMA) terpolymer STG1 in PBS into the tube Buffer solution, reacted at 60°C for 2h under shaking. The tubes were then removed and rinsed repeatedly with deionized water to remove physically attached copolymer to the surface. Finally, the film was put into a vacuum drying oven, and dried to a constant weight at room temperature to obtain a coating of the PVC pipe inner surface modification copolymer STG1. As in Table 2.

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Abstract

The invention relates to a coating modified with zwitterion random copolymers on the surface and containing epoxy functional groups as well as a preparation method and an application of the coating. The coating is a surface coating formed by chemically bonding random copolymers of 3-sulfopropyl methacrylate, methacryloyloxyethyl trimethyl ammonium chloride and glycidyl methacrylate to a material surface through a reaction between epoxy groups and material surface active groups; the material surface with the active groups is soaked in an aqueous solution of the zwitterion random copolymers with the epoxy functional groups or a PBS (poly butylenes succinate) buffer solution and is subjected to a reaction for 2-6 h under the magnetic stirring action at the temperature of 20-60 DEG C, the material surface is enabled to be grafted with the copolymers to form the coating, the copolymers physically attached to the material surface are removed through repeated washing with deionized water, then the coating is placed in a vacuum drying oven and dried to the constant weight at the room temperature, and the random copolymer surface coating with the material surface modified is obtained. The coating is applicable to surface modification of medical apparatus, catheters, blood contact materials and the like.

Description

technical field [0001] The present invention relates to a zwitterionic random copolymer surface-modified coating with epoxy functional groups, as well as a preparation method and application, and is characterized in that the zwitterionic random copolymer surface-modified coating has better anti-bioadhesion properties , which is an innovative new material and surface modification technology. [0002] technical background [0003] Medical catheters, blood storage bags, surgical guide wires and various extracorporeal circulation devices have been widely used clinically. However, the existing devices still have biocompatibility problems during use, often causing non-specific adsorption of some biomolecules or organisms such as proteins, cells, and bacteria on the surface of the material, especially when they are in direct contact with blood, platelet adhesion will be induced , the formation of thrombus. Therefore, it is of great significance to modify the surface of biomedical ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/34A61L27/50A61L29/14A61L29/08
CPCA61L27/34A61L27/50A61L29/085A61L29/14A61L2400/18A61L2420/02C08L33/14
Inventor 董岸杰唐敏捷邓联东
Owner 天津渤化讯创科技有限公司
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