Preparation method of graphene oxide-based hybrid biological functional coating

A graphene, hybrid technology, applied in coating, metal material coating process, nanotechnology for materials and surface science, etc., can solve the problems of low mechanical properties and fast degradation speed of collagen, and achieve excellent biological The effect of function, less equipment investment, and simple and easy preparation method

Active Publication Date: 2017-02-22
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, collagen has low mechanical properties and degrades rapidly

Method used

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  • Preparation method of graphene oxide-based hybrid biological functional coating
  • Preparation method of graphene oxide-based hybrid biological functional coating
  • Preparation method of graphene oxide-based hybrid biological functional coating

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Ultrasonic disperse graphene oxide into a 1.5mg / ml solution, take 50ml and add 0.0849g silver nitrate, stir for 30 minutes, and place in vacuum for 2 days;

[0030] (2) irradiate the solution with 273.5nm ultraviolet light for 1 hour under stirring condition, and set aside;

[0031] (3) Polish the titanium sheet to a smooth mirror surface with sandpaper of specifications 240#, 400#, 600#, 800#, and 1200# respectively, and then use HF:1moL / LHNO with a volume ratio of 1:4:5 3 :H 2 The mixed solution of O is chemically etched for 2 minutes;

[0032] (4) Then put it into a reaction kettle filled with 4mol / L KOH solution, put the reaction kettle into an oven, react at 80°C for 90 minutes, and finally take it out for washing and drying;

[0033] (5) The titanium sheet after the above treatment was immersed in 2 mg / mL dopamine Tris-HCl (pH=8.5) buffer solution in the dark, left for 24 hours, taken out, washed and dried. Immerse again in the graphene oxide / nano-silver co...

Embodiment 2

[0035] (1) Prepare the graphene oxide / silver nitrate solution whose concentration is 2.5mg / L and 0.03mol / L respectively, place the prepared graphene oxide / silver nitrate solution in vacuum for 3 days, then irradiate with ultraviolet light under continuous stirring Reduction to obtain a graphene oxide composite material uniformly loaded with nano-silver;

[0036] (2) After polishing the surface of a titanium metal disc with a diameter of 6mm and a thickness of 2.5mm with sandpaper step by step, ultrasonically clean it in acetone, distilled water, and alcohol in sequence, and then put it into a reaction kettle filled with a KOH solution with a concentration of 3mol / L , put the reactor into an oven, react at 60°C for 90 minutes, take it out, wash and dry;

[0037] (3) Immerse the titanium sheet after the above treatment in a dark condition with a concentration of 3 mg / ml and place it in a dopamine Tris-HCl buffer solution with a pH of 8.5 for 20 hours, take it out, wash and dry i...

Embodiment 3

[0040] (1) Prepare graphene oxide / silver nitrate solutions with concentrations of 2mg / L and 0.02mol / L respectively, place the prepared graphene oxide / silver nitrate solution in vacuum for 3 days, then irradiate and reduce with ultraviolet light under continuous stirring Obtain a graphene oxide composite material uniformly loaded with nano-silver;

[0041](2) Grind the titanium sheet with sandpaper of 240#, 400#, 600#, 800#, and 1200# on a polishing grinder to a smooth mirror surface, and then use concentrated H with a volume ratio of 3:1 2 SO 4 :H 2 o 2 The mixed solution chemically etched for 30 minutes;

[0042] (3) The titanium sheet after the above treatment was immersed in 2 mg / mL dopamine Tris-HCl (pH=8.5) buffer solution in the dark, left for 24 hours, taken out, washed and dried. Then immerse in the graphene oxide / nano-silver composite material prepared above for 24h. Take out, wash and dry;

[0043] (4) Collagen is dissolved in 3.5% acetic acid solution to make ...

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Abstract

The invention relates to a preparation method of a graphene-oxide-based hybrid biological functional coating. The preparation method comprises the following steps: 1, preparing a graphene oxide/nanosilver composite material; 2, treating a titanium sheet; 3, grafting the titanium sheet with the graphene oxide/nanosilver composite material; 4, preparing a graphene oxide/nanosilver/collagen hybrid coating. The preparation method has the advantages as follows: (1) by a method for reducing nanosilver by using ultraviolet, the uniformly-dispersed nanosilver with a small size can be obtained, and adverse effects on the environment are avoided; (2) on the basis of graphene oxide, graphene oxide, collagen and nanosilver are organically combined, and through coordinated action of the three components, respective shortcomings can be improved, so that the graphene-oxide-based hybrid biological functional coating has a more excellent biological function; (3) when the preparation method provided by the invention is used for preparing the graphene oxide-based hybrid biological functional coating, the equipment investment and the implementing difficulty are low; the preparation method is simple and feasible; by the preparation method, too much influence on the environment is avoided.

Description

technical field [0001] The invention relates to a preparation method of a functional coating, in particular to a preparation method of a graphene oxide-based hybrid biological functional coating. Background technique [0002] Biomedical materials are materials that are used to diagnose, treat, repair, or replace diseased tissues and organs of living organisms or enhance their functions, and will not have adverse effects on biological tissues. It can be divided into medical metal materials, medical polymer materials, medical ceramics and medical composite materials. Medical titanium metal has excellent mechanical properties, strong corrosion resistance, low elastic modulus, good biocompatibility and other excellent characteristics. It is currently a commonly used internal fixation material in orthopedics. Load parts are widely used. [0003] However, more and more people have paid attention to the bacterial infection caused by medical implants, and once it occurs, it will n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/30A61L27/50A61L27/54C23C18/14B82Y30/00C23F1/26C23F1/38
CPCA61L27/306A61L27/34A61L27/50A61L27/54A61L2300/104A61L2300/404A61L2400/18A61L2430/02B82Y30/00C23C18/14C23F1/26C23F1/38C08L89/00
Inventor 吴水林谢显洲刘想梅刘泽慧
Owner HUBEI UNIV
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