Preparation method of composite carboxymethyl chitosan/graphene oxide/polyacrylamide hydrogel

A technology of carboxymethyl chitosan and composite hydrogel is applied in the field of preparation of carboxymethyl chitosan/graphene oxide/polyacrylamide composite hydrogel, which can solve the problem of low elongation at break, low tensile strength problems such as poor tensile strength and mechanical properties, to achieve the effects of good biocompatibility, improved mechanical properties, and easy operation

Active Publication Date: 2017-02-22
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Polyacrylamide hydrogel is widely used in the field of biomedicine (such as tissue engineering, drug release, etc.) because of its low toxicity and good biocompatibility, but its mechanical properties are poor.
Most of the hydrogels are formed by absorbing and swelling the three-dimensional hydrophilic polymer network cross-linked by covalent bonds, and usually exhibit the characteristics of poor mechanical properties (such as: brittle, low elongation at break, low tensile strength, etc.), Therefore, its application fields are limited to a certain extent, how to improve the mechanical properties of hydrogels has become a hot research topic for scholars in recent years.

Method used

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  • Preparation method of composite carboxymethyl chitosan/graphene oxide/polyacrylamide hydrogel
  • Preparation method of composite carboxymethyl chitosan/graphene oxide/polyacrylamide hydrogel
  • Preparation method of composite carboxymethyl chitosan/graphene oxide/polyacrylamide hydrogel

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Embodiment 1

[0034] The preparation method of carboxymethyl chitosan:

[0035] A: First soak 5g of chitosan in 45ml of isopropanol and swell at room temperature for 17h, then add 30g of 50wt% sodium hydroxide solution for alkalization for 2h, stir mechanically at 50°C, and add in isopropanol drop by drop. The chloroacetic acid solution of propanol (8.5g chloroacetic acid is dissolved in 5ml isopropanol), reacted 4h, the product obtained was first washed with 1wt% dilute hydrochloric acid until it was close to neutrality, and then the volume fraction was 90% ethanol, no Wash with water and ethanol for 3-4 times, filter with suction, and dry in an oven at 45° C. to obtain crude carboxymethyl chitosan.

[0036] B: Dissolve the crude product in deionized water, stir to make it fully dissolved, add excess acetone to precipitate carboxymethyl chitosan, and wash the precipitated carboxymethyl chitosan with absolute ethanol 3-4 times, then vacuum Dried in an oven to obtain pure carboxymethyl chit...

Embodiment 2

[0046] The preparation method of carboxymethyl chitosan is identical with embodiment.

[0047] Preparation method of carboxymethyl chitosan / graphene oxide / polyacrylamide composite hydrogel

[0048] (1) Preparation of graphene oxide aqueous solution: Weigh 0.3g of graphite oxide powder, add it to a 250ml beaker, add 150ml of deionized water, stir for 3h to make it evenly dispersed; use a cell pulverizer to crush and peel off for 1h, and centrifuge at 600rpm for 1h to remove After the lower layer is precipitated, centrifuge at 10,000rpm for 2 hours to remove the upper layer solution, add deionized water to the lower layer of precipitation, and stir evenly to obtain a graphene oxide aqueous solution with a concentration of 3.68 mg / ml;

[0049] (2) Prepare initiator aqueous solution: take by weighing initiator potassium persulfate 2g and dissolve 100ml deionized water, fully stir and make it dissolve completely, obtain the potassium persulfate aqueous solution that concentration i...

Embodiment 3

[0055] The preparation method of carboxymethyl chitosan is with embodiment 1.

[0056] (1) Preparation of graphene oxide aqueous solution: Weigh 0.3g of graphite oxide powder, add it to a 250ml beaker, add 150ml of deionized water, stir for 3h to make it evenly dispersed; use a cell pulverizer to crush and peel off for 1h, and centrifuge at 600rpm for 1h to remove After the lower layer is precipitated, centrifuge at 10,000rpm for 2 hours to remove the upper layer solution, add deionized water to the lower layer of sediment, and stir evenly to obtain a graphene oxide aqueous solution with a concentration of 3.46mg / ml;

[0057] (2) Prepare initiator aqueous solution: take by weighing initiator potassium persulfate 2g and dissolve 100ml deionized water, fully stir and make it dissolve completely, obtain the potassium persulfate aqueous solution that concentration is 0.02g / ml;

[0058] (3) Preparation of carboxymethyl chitosan / graphene oxide / polyacrylamide composite hydrogel: add ...

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Abstract

The invention relates to a preparation method of a composite carboxymethyl chitosan/graphene oxide/polyacrylamide hydrogel. The preparation method includes the steps of adding CMCTs (carboxymethyl chitosan) in a GO (graphene oxide) solution, stirring, adding AM (acrylamide), and stirring to obtain a CMCTs/GO/AM dispersion solution; under the conditions of stirring and ice-water bath, adding an initiator solution and an accelerating agent into the dispersion solution, and stirring to obtain a mixed solution; placing the mixed solution in a container, vacuumizing, inflating nitrogen, sealing, and reacting at a room temperature for 8-12 hours to obtain the composite carboxymethyl chitosan/graphene oxide/polyacrylamide hydrogel. The preparation method is simple in preparing process, easy to operate and beneficial to industrial production; the prepared composite carboxymethyl chitosan/graphene oxide/polyacrylamide hydrogel is high in biocompatibility, mechanical property and toughness, can be used for artificial skin, artificial ligament and the like and has a potential application value in histological engineering.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, in particular to a preparation method of carboxymethyl chitosan / graphene oxide / polyacrylamide composite hydrogel. Background technique [0002] Carboxymethyl chitosan is a water-soluble chitosan derivative prepared by reacting chitosan with chloroacetic acid under strong alkaline conditions. It is an amphoteric polyelectrolyte, non-toxic, tasteless, and has good biological properties. compatibility and degradability. Due to the introduction of carboxyl groups, the solubility of carboxymethyl chitosan is better than that of chitosan, and it can be dissolved in aqueous solution in a wide pH range, which greatly broadens its application fields, such as agriculture, medicine, sewage treatment, cosmetics, tissue engineering etc. [0003] Graphene oxide is an important derivative of graphene. It is a product obtained by oxidizing and exfoliating natural flake graphite under strong acid cond...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L33/26C08L5/08C08K7/00C08K3/04C08F120/56
CPCC08F120/56C08J3/075C08J2333/26C08J2405/08C08L33/26C08L5/08C08K7/00C08K3/04
Inventor 于俊荣陈阳胡祖明王彦诸静
Owner DONGHUA UNIV
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