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Anhydrous toothpaste for repairing demineralized tooth enamel and dentin and preparation method thereof

A toothpaste and calcite technology, which is applied in the field of daily life chemicals, can solve the problems of paste instability, thermodynamic imbalance, chemical reaction, etc., and achieve the effect of uniform and stable paste, easy industrialization, and simple process

Active Publication Date: 2020-04-21
HANGZHOU JIAOJIE ORAL HEALTH CARE PRODS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, some water-soluble phosphates such as disodium hydrogen phosphate and calcium carbonate have thermodynamic imbalance in the water-containing paste, and chemical reactions will occur, causing the paste to be unstable

Method used

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  • Anhydrous toothpaste for repairing demineralized tooth enamel and dentin and preparation method thereof
  • Anhydrous toothpaste for repairing demineralized tooth enamel and dentin and preparation method thereof
  • Anhydrous toothpaste for repairing demineralized tooth enamel and dentin and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0046] The preparation method of described anhydrous toothpaste, comprises the steps:

[0047] S1. Put the above components in a mixer at 800rpm and stir for 40min;

[0048] S2, vacuum degassing into paste.

[0049] Example Toothpaste 2

[0050] The present embodiment provides a kind of anhydrous toothpaste 2, by mass percentage, is made up of following raw material:

[0051]Polyethylene glycol 400 6.0wt%, micron grade calcium carbonate 8wt%, hydrated silicon dioxide 22wt%, the mass ratio of disodium hydrogen phosphate is 3.41wt%, carbomer 0.4wt%, saccharin 0.22wt%, lemon Zinc acid 0.1 wt%, sodium lauryl sulfate 2.0 wt%, sodium monofluorophosphate 0.76 wt%, essence 1.2 wt%, the rest is glycerin; the micron calcium carbonate is calcite crystal form, filtered through a 1200-mesh sieve , with an average particle size of 13 µm or less.

[0052] The preparation method of described anhydrous toothpaste, comprises the steps:

[0053] S1. Put the above components in a mixer at 80...

experiment example 1

[0067] Experimental example 1 In vitro repair experiment of demineralized tooth enamel

[0068] First, prepare simulated oral saliva (SOF), the specific components are as follows: 137.35 mM NaCl, 4.17 mM NaHCO 3 , 3.01 mM KCl, 7.17 mM K 2 HPO 4 •3H 2 O, 1.53 mM MgCl 2 •6H 2 O, 20.00 mM HCl, 0.90 mM CaCl 2 , 0.51 mM Na 2 SO4 and Tris adjust the pH to 7.0.

[0069] Use a low-speed diamond cutting machine (SYJ-160 low-speed diamond cutting machine) to cut bovine teeth to prepare enamel slices with a thickness of 2 mm, and then polish them with 200, 400, 1000, 2000 and 4000-mesh silicon carbide water sandpaper until the surface is bright Smooth; finally polished smooth with 3M polishing paper (3 microns), and ultrasonically cleaned in deionized water for 3 min, set aside. Use a micro-Vickers hardness tester (HV-1000Z type, load 500gf, 15 seconds) to measure the micro-Vickers hardness of the enamel surface. According to the hardness, select the appropriate enamel samples an...

experiment example 2

[0072] Experimental example 2 In vitro repair experiment of demineralized dentin

[0073] Healthy third molars extracted due to orthodontics (informed consent of the patients) were collected in a stomatological hospital, fully cleaned and put into 0.5 wt% thymol aqueous solution. Use a low-speed diamond cutting machine (SYJ-160 low-speed diamond cutting machine) to prepare dentin slices with a thickness of 2 mm, and then polish them with 200, 400, 1000, 2000 and 4000 mesh silicon carbide water sandpaper until the surface is bright and smooth; Polished with 3M polishing paper (3 microns), ultrasonically cleaned in deionized water for 3 min, and set aside.

[0074] Before use, put each dentin slice in 36 wt% phosphoric acid aqueous solution for demineralization treatment for 2 min, then rinse with deionized water for 3 min, take out 3 dentin slices as samples before toothpaste treatment for characterization analysis, and divide the rest randomly Into 4 groups, 3 tablets in each...

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Abstract

The invention relate to anhydrous toothpaste containing water-soluble phosphate, micron-sized calcium carbonate and fluoride. The mass percent of water-soluble phosphate is larger than 2.0 wt%, the mass percent of micron-sized calcium carbonate is less than 40 wt%, the mass ratio range of water-soluble phosphate and micron-sized calcium carbonate is 1 / 10-5, and the mass concentration of fluorine of fluoride in the toothpaste is less than 8.0 wt%. When the anhydrous toothpaste containing water-soluble phosphate and micron-sized calcium carbonate is used, biological mineralization can be helped to be conducted on demineralized enamel and demineralized dentin slices, the enamel surface is repaired, the bore diameters of dental canaliculi on the dentin dental face is reduced, and even dentinal tubules are blocked. At the same time, fluoride is hydrolyzed to generate fluoride ions, the mineralization process of hydroxyapatite in teeth is promoted, and the repairing function of the toothpaste on enamel and dentin is improved.

Description

technical field [0001] The invention belongs to the technical field of daily life chemicals, and in particular relates to an anhydrous toothpaste capable of mineralizing and repairing demineralized tooth enamel and demineralized dentin and a preparation method thereof. Background technique [0002] Toothpaste has become a necessity in people's daily life. With the improvement of people's living standards, the emergence of bad diet structure and high sugar intake threaten people's oral health. High sugars, especially sucrose, that remain in the mouth and are broken down into acids that attack the tooth enamel and exposed dentin, causing demineralization of the enamel and dentin and, in severe cases, causing caries, tooth loss, or tooth sensitivity A series of diseases, such as serious impact on people's health. Therefore, it is of great significance to develop a toothpaste that can restore the surface of demineralized enamel and demineralized dentin. [0003] Anhydrous too...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/24A61K8/19A61Q11/00
CPCA61K8/19A61K8/24A61K2800/31A61Q11/00
Inventor 丁观军程吉平吴兴合
Owner HANGZHOU JIAOJIE ORAL HEALTH CARE PRODS
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