Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of porous structural ceramic material

A ceramic material and porous structure technology, which is applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of poor pore connectivity and complicated process of porous scaffolds, and achieve the effect of less impurities, simple process and convenient operation

Inactive Publication Date: 2017-03-22
SOUTHWEST JIAOTONG UNIV
View PDF4 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, if hard inorganic particles are used to form pores, it is difficult to form surface-to-surface contact between particles, and the porous scaffold has poor pore penetration; wax balls and polymethyl methacrylate particles are used as pore-forming agents, which need to be promoted by adding organic solvents. Particles are slightly soluble, forming surface-to-surface contact to improve the connectivity between the macropores of porous materials, but the process is more complicated

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of porous structural ceramic material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Step 1. Preparation of ceramic slurry: Take 5g of anhydrous lithium chloride and add it to 100mL dimethylacetamide. After the dissolution is complete, add 0.7g of chitin to form a sol after dissolution, and then add 10g of hydroxyapatite powder to make it evenly mixed , kept heating and stirring during this process, to obtain a ceramic slurry with a mass volume ratio of 10%.

[0017] Step 2: Take 200ml of deionized water and heat it to 65°C, add 2g of sodium alginate, and after it dissolves, form droplets through the needle of a 5ml syringe at room temperature and freely drop them into a calcium chloride solution with a mass-volume ratio of 1% to cross-link to form a spherical shape Sodium alginate gel particles, filter out the gel particles, add deionized water to wash to remove residual calcium chloride.

[0018] Step 3. Soak the spherical sodium alginate gel particles obtained in Step 2 in pure ethanol for ten minutes, then filter out, and repeat the ethanol soaking ...

Embodiment 2

[0022] Step 1. Preparation of ceramic slurry: Take 5g of anhydrous lithium chloride and add it to 100mL dimethylacetamide. After the dissolution is complete, add 0.7g of chitin to form a sol after dissolution, and then add 20g of hydroxyapatite powder to make it evenly mixed , keep heating and stirring during this process, and obtain a ceramic slurry with a mass volume ratio of 20%.

[0023] Step 2: Take 200ml of deionized water and heat it to 65°C, add 2g of sodium alginate, and after dissolving, form a droplet at room temperature through the needle of a 20ml syringe and freely drop it into a calcium chloride solution with a mass-volume ratio of 1% to form spherical alginate Sodium gel particles, filter out the gel particles, add deionized water to wash and remove residual calcium chloride.

[0024] Step 3: Soak the spherical sodium alginate gel particles in pure ethanol for ten minutes, filter out, and repeat the ethanol soaking step three times to obtain solidified sodium a...

Embodiment 3

[0028] Step 1. Preparation of ceramic slurry: Take 100ml of deionized water and heat it to 65°C, add 4g of gelatin, add 2g of carboxymethyl chitosan after dissolving, add 1.2g of sodium citrate after five minutes, and then add 35g of biphasic phosphoric acid Calcium (hydroxyapatite / tricalcium phosphate) powder was mixed uniformly, and heating and stirring were kept during the process to obtain a ceramic slurry with a mass volume ratio of 35%.

[0029] Step 2: Take 200ml of deionized water and heat it to 65°C, add 3g of sodium alginate, after it dissolves, form a droplet at room temperature through the needle of a 20ml syringe and freely drop it into a calcium chloride solution with a mass-volume ratio of 1% to form spherical alginate Sodium gel particles, filter out the gel particles, add deionized water to wash and remove residual calcium chloride.

[0030] Step 3: Soak the spherical sodium alginate gel particles in pure ethanol for ten minutes, then filter out, and repeat th...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention provides a preparation method of a porous structural ceramic material, and belongs to the technical field of ceramic material preparation methods. The preparation method comprises the following steps: I, preparing a ceramic slurry which contains 10-35% of calcium phosphate in mass-volume percentage; II, preparing sodium alginate particles: preparing a sodium alginate solution which is 1-2% in mass-volume percentage, promoting free dropping of the solution into 1% of a calcium chloride solution in the form of liquid drops by virtue of a needle, and conducting cross-linking, so that the spherical sodium alginate gel particles are prepared; III, repeatedly soaking the spherical sodium alginate gel particles obtained in the step II in pure ethanol for three times, so that cured sodium alginate particles are obtained, wherein each time lasts for 10min; IV, stacking the cured sodium alginate particles obtained in the step III in a die, applying pressure so that the particles get into face-to-face contact, injecting the ceramic slurry into the die so as to obtain a porous material in the form of a gel in the die after the gelatinization of the slurry, and drying the porous material at 40 DEG C so as to obtain an initial blank; and V, calcining the initial blank at furnace temperature of 500 DEG C for 1h, and sintering the initial blank at increased temperature of 1000-1200 DEG C, so that the porous structural ceramic material is prepared.

Description

technical field [0001] The invention belongs to the technical field of ceramic material preparation methods, in particular to the preparation technology of porous structure bioceramic supports. Background technique [0002] Bioceramic has excellent biocompatibility when used as artificial bone material, and is non-toxic and non-irritating. The bioceramic material that guides or induces bone tissue growth is mainly in the form of a three-dimensional porous perforated scaffold, which not only plays a supporting role in bone tissue culture and bone regeneration therapy, provides space for tissue growth, but also provides cells for adhesion and proliferation. and differentiation sites, thereby guiding the regeneration and repair of damaged tissues. The permeability and porosity of the porous scaffold determine the growth of blood vessels, so as to ensure the nutrients and oxygen necessary to maintain the metabolism of cells in the scaffold, so that cells with osteogenic differe...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/56A61L27/10A61L27/12A61L27/20A61L27/02
CPCA61L27/025A61L27/10A61L27/12A61L27/20A61L27/56A61L2430/02C08L5/04
Inventor 翁杰匙峰智伟周腾何旭周杰屈树新汪建新
Owner SOUTHWEST JIAOTONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com