Clarithromycin derivatives and their preparation methods and applications

A technology for clarithromycin and derivatives, applied in the field of clarithromycin derivatives, can solve the problems of complicated operation steps, high cost, unsuitable for screening and detection of large-scale samples, etc., and achieves the analysis of large sample volume, low cost and high sensitivity. Effect
CN106588857BActive Publication Date: 2019-11-12深圳市绿诗源生物技术有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
深圳市绿诗源生物技术有限公司
Publication Date
2019-11-12

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Abstract

The invention discloses a clarithromycin derivative, and a preparation method and application thereof. The invention aims to provide the clarithromycin clarithromycin derivative which can maintain the feature structure of clarithromycin to the greatest degree and has an active group capable of coupling with carrier protein; an artificial antigen and an antibody are prepared from the clarithromycin derivative to be used for detecting macrolide compounds; according to the technical scheme, the structure of the clarithromycin derivative is as shown in the following formula; the clarithromycin artificial antigen is prepared by coupling the clarithromycin derivative with the carrier protein; the invention belongs to the field of a biotechnology; and (the formula is as shown in the description).
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Description

technical field

[0001] The invention belongs to the field of biotechnology, and specifically relates to a clarithromycin derivative and the application of the clarithromycin derivative as a hapten in the preparation of a clarithromycin coating agent and an immunogen. Background technique

[0002] Clarithromycin belongs to macrolide antibiotics and is effective against most Gram-positive bacteria, some Gram-negative bacteria and some atypical pathogenic bacteria (mycoplasma, chlamydia, etc.). It is one of the second-generation derivatives of erythromycin. The main members of the second-generation derivatives of erythromycin include roxithromycin, azithromycin, clarithromycin, and dirithromycin. Because its second-generation derivatives avoid being destroyed by gastric acid, improve the absorption rate, and have stronger antibacterial activity, they are widely used as first-line drugs for the treatment of respiratory tract infections.

[0003] However, it has been reported r...

Claims

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