Production method for drug balloon

Abstract

The invention discloses a production method for a drug balloon. The production method comprises the following steps: 1) preparing a medicinal solution; 2) spraying the medicinal solution on the surface of a balloon with layer by layer through a multi-time spraying technology. The production method has the beneficial effects that an oversaturated paclitaxel medicinal solution is prepared, and is directly applied to ultrasonic spraying to obtain a completely-crystallized medicinal coating. The multi-time spraying technology is used, and the medicinal coating is subjected to solvent steam treatment to obtain a medicinal coating with a small crystal size and a good binding effect between the crystal and a substrate. The drug balloon produced by the production method has the advantages that medicinal loss can be lowered greatly in passing and expanding processes, and the drug utilization rate is increased.

Description

technical field [0001] The invention relates to the technical field of production of drug balloons, in particular to a production method of drug balloons. Background technique [0002] Drug balloon is a new type of therapeutic balloon drug release technology developed on the basis of interventional techniques such as balloon dilatation or balloon angioplasty. It coats the surface of the balloon with anti-proliferative drugs, such as paclitaxel, When the balloon reaches the lesion site, the blood vessel wall is stretched and expanded, and when it comes into contact with the intima of the blood vessel wall, the drug is rapidly released and transferred in the local blood vessel wall, and the drug plays an anti-vascular intimal hyperplasia effect locally , so as to prevent vascular restenosis after vascular intervention. [0003] The drug of choice for drug balloons is paclitaxel. Since paclitaxel is fat-soluble, it can be rapidly absorbed by vascular smooth muscle cells and re...

AI Technical Summary

Problems solved by technology

[0020] In order to solve the problem that the drug crystals of the drug balloon obtained by the prior art are large in size, the crystals are loose, and the combination between the crystal and the carrier is not firm, resulting in a low firmness of the drug coating. There will be a large loss, the drug utilization rate is low, and the large crystal size may cause the drug coating to produce drug particles during the operation. These drug particles enter the microcirculatory system or capillaries along with the blood circulation, which is easy to cause thrombus blockage However, the present invention provides a method for producing drug balloons, which can produce drug balloons with high drug coating firmness and small drug particle size, which can greatly reduce drug loss during drug balloon crossing and expansion. Improve drug utilization

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