Strychnine percutaneous patch for treating hemiplegia and preparation method thereof

Abstract

The invention belongs to the technical field of medicines, and relates to a strychnine percutaneous patch for treating hemiplegia and a preparation method thereof. The patch consists of a backing layer, a medicine storage bank and an antisticking layer, wherein the medicine storage bank comprises main medicines of strychnine, a transdermal enhancer and a pressure sensitive adhesive; the consumption of the strychnine accounts for 0.2 weight percent to 10 weight percent of the mass of the medicine storage bank; the transdermal enhancer accounts for 0.5 weight percent to 20 weight percent of the mass of the medicine storage bank. The strychnine contained by the patch can be constantly released from the medicine storage bank; the constant-speed percutaneous absorption is realized; the relatively stable blood concentration is maintained, so that the patch can avoid toxic reaction caused by plasma drug peak concentration during strychnine injection administration; a safe and efficient novel preparation is provided for the strychnine for clinically treating the hemiplegia; foreseeable social and economic values are realized.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and relates to a strychnine transdermal patch for treating hemiplegia and a preparation method thereof. Background technique [0002] Stroke, commonly known as stroke, is an acute cerebral blood circulation disorder caused by various predisposing factors that cause stenosis, occlusion or rupture of the intracerebral artery. In my country, stroke is a disease of middle-aged and elderly people with very high morbidity, mortality, and disability. 50-70% of surviving patients have severe sequelae such as hemiplegia and aphasia, which brings a heavy burden to society and families. At present, treatment methods such as exercise therapy, physical therapy, and rehabilitation engineering are mainly used for stroke hemiplegia, but these methods mostly require the participation of professional medical staff, and the rehabilitation cycle is long and the treatment cost is high. At present, there are few clinical...

AI Technical Summary

Problems solved by technology

However, due to the excellent barrier function of the stratum corneum of the skin, the transdermal penetration rate of the drug is often very low, and it is difficult to achieve the effective blood drug concentration of the whole body through transdermal absorption.

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