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Dentin desensitization material resistant to acid, abrasion and caries and preparation method thereof

A dentin and desensitization technology, applied in the field of biomedical engineering, can solve problems such as unreported research, achieve the effect of process parameter control, simple preparation process, and caries prevention

Active Publication Date: 2019-12-10
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, no research has been reported on this

Method used

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  • Dentin desensitization material resistant to acid, abrasion and caries and preparation method thereof
  • Dentin desensitization material resistant to acid, abrasion and caries and preparation method thereof
  • Dentin desensitization material resistant to acid, abrasion and caries and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] (1) At room temperature, weigh 0.944 g of calcium nitrate tetrahydrate and 0.3168 g of diammonium hydrogen phosphate into a beaker filled with 60 mL of double-distilled water, respectively, and dissolve them in a beaker filled with 60 mL of double-distilled water. Sonicate for 5 minutes at a power of 400 W. Place on a magnetic stirrer and stir for 15 minutes to obtain liquid I and liquid II respectively;

[0038] (2) Weigh 0.24 g of dry mesoporous silicon powder into a beaker filled with 20 mL of double-distilled water, and disperse ultrasonically for 5 minutes at a power of 400 W to obtain liquid III, which is then placed on a magnetic stirrer at a stirring speed of Slowly add liquid I to liquid III dropwise at 200 rpm, adjust and keep the pH value between 10-10.5, stir for 12 hours to obtain liquid IV;

[0039] (3) Slowly add liquid II to liquid IV dropwise at a stirring speed of 200 rpm, adjust and maintain the pH value between 10-10.5, and stir for 30 hours to obtai...

Embodiment 2

[0046] (1) At room temperature, weigh 1.888g of calcium nitrate tetrahydrate and 0.6336g of diammonium hydrogen phosphate into a beaker filled with 60 mL of double-distilled water, respectively, and dissolve them in a beaker filled with 60 mL of double-distilled water. Sonicate for 5 minutes at a power of 400 W. Stir on a magnetic stirrer at 400 rpm for 15 minutes to obtain liquid I and liquid II respectively;

[0047] (2) Weigh 0.48 g of dry mesoporous silicon powder into a beaker filled with 20 mL of double-distilled water, and disperse ultrasonically for 5 minutes at a power of 400 W to obtain liquid III, which is then placed on a magnetic stirrer at a stirring speed of Slowly add liquid I to liquid III dropwise at 300 rpm, adjust and maintain the pH value between 10-10.5, stir for 12 hours to obtain liquid IV;

[0048] (3) Slowly add liquid II to liquid IV dropwise at a stirring speed of 300 rpm, adjust and maintain the pH value between 10-10.5, and stir for 30 hours to ob...

Embodiment 3

[0055] (1) At room temperature, weigh 3.776g of calcium nitrate tetrahydrate and 1.2672g of diammonium hydrogen phosphate into a beaker filled with 60 mL of double-distilled water, respectively, and dissolve them in a beaker filled with 60 mL of double-distilled water. Put it on a magnetic stirrer and stir for 15 minutes to obtain liquid I and liquid II respectively;

[0056] (2) Weigh 0.96 g of dry mesoporous silicon powder into a beaker filled with 40 mL of double-distilled water, and ultrasonically disperse at a power of 400 W for 5 minutes to obtain liquid III, which is then placed on a magnetic stirrer at a stirring speed of Slowly add liquid I to liquid III dropwise at 400 rpm, adjust and maintain the pH value between 10-10.5, stir for 12 hours to obtain liquid IV;

[0057] (3) Slowly add liquid II to liquid IV dropwise at a stirring speed of 400 rpm, adjust and maintain the pH value between 10-10.5, and stir for 30 hours to obtain liquid V;

[0058] (4) After aging for...

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Abstract

The invention discloses an acid-resistant, wear-resistant and anticarious dentin desensitizing material and a preparation method thereof. An EGCG (epigallocatechin gallate)-loaded nano hydroxyapatite / mesoporous silicon composite material is prepared by utilizing characteristics of high biological activity and inhibition of formation of a cariogenic bacterium biofilm of EGCG, characteristics of strong adsorption, acid resistance and wear resistance of mesoporous silicon nano-particles, and characteristic of mineralization promotion of nano hydroxyapatite. The prepared composite material has the advantages of simple and convenient process, easy parameter control, stable material structure, good dispersity, uniform particle size, and high loading rate and high release rate of EGCG. The EGCG-loaded nano hydroxyapatite / mesoporous silicon composite material prepared with the preparation method provided by the invention can be used as an acid-resistant, wear-resistant and anticarious dentin desensitizing material, to effectively close dentinal tubules in treatment of dentin hypersensitivity on the one hand, and effectively inhibit the formation of the cariogenic bacterium biofilm and prevent caries diseases on the other hand.

Description

technical field [0001] The invention relates to the field of biomedical engineering, in particular to an acid-resistant, wear-resistant and caries-resistant dentin desensitization material and a preparation method thereof. Background technique [0002] As one of the most common oral diseases in adults, dentine sensitivity mainly results from the exposure of dentinal tubules caused by enamel loss and / or gingival recession, which causes transient, sharp pain. According to classical hydrodynamic theory (Brannstrom M. J Am Dent Assoc, 1963;66:366–370.), effective sealing of dentinal tubules is considered to be a reliable means of reducing fluid flow in the tubules and thus relieving sensitivity symptoms. After decades of development, satisfactory results have been achieved in the treatment of dentin hypersensitivity by sealing dentinal tubules with oxalate, fluoride, adhesives, and laser treatment. However, in the complex oral environment, the closed tubules are often difficult...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K6/033A61K6/027A61K6/838
CPCA61K6/20A61K6/69A61K6/831A61K6/838
Inventor 黄翠喻健杨宏业
Owner WUHAN UNIV
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