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Anti-adhesion compound dural patch and preparation method thereof

An anti-adhesion and dura mater technology, applied in the field of medical materials, can solve the problems of limited anti-adhesion and anti-cerebrospinal fluid leakage, and achieve the effects of preventing cerebrospinal fluid leakage, preventing fiber shedding, and accelerating repair

Inactive Publication Date: 2017-06-30
SHANGHAI DIVINE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the existing patents, although the selection of different materials has a certain anti-adhesion function, its anti-adhesion and anti-cerebrospinal fluid leakage effects are very limited

Method used

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  • Anti-adhesion compound dural patch and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] figure 1 Be the structure of dura mater patch in the present embodiment, as figure 1 As shown, the dura mater patch is composed of a functional layer 1 and an anti-adhesion layer 2 . The functional layer 1 is a nanofiber film, and the anti-adhesion layer 2 is a dense film.

[0025] (1) Preparation of dense film: select polyethylene glycol-modified polylactic acid, the proportion of polyethylene glycol is 20%, as a copolymerized polymer raw material, with a weight average molecular weight of 200,000, dissolved in ethyl acetate, ultrasonically vibrated, filtered, press The ratio is added to a polytetrafluoroethylene plate with grooves, cast to form a film, placed in a vacuum drying oven, and vacuum-dried for 24 hours to obtain a soft and dense film with a thickness of 0.03 mm, which is the anti-adhesion layer 2.

[0026] (2) Preparation of composite structure: preparation of electrospinning stock solution: select chitosan and polylactic acid at a ratio of 50:50, dissolv...

Embodiment 2

[0031] (1) Preparation of dense film: select caprolactone-modified polylactic acid, the proportion of caprolactone is 15%, as a copolymerized polymer raw material, with a weight average molecular weight of 200,000, heated and blown into a film to obtain a soft and dense film with a thickness of 0.02mm membrane.

[0032] (2) Preparation of composite structure: preparation of electrospinning stock solution: choose polylactic acid and PEG6000 in a ratio of 70:30 and dissolve in chloroform, ultrasonically vibrate, filter, and set aside.

[0033] Add the above solution into the injection device of the spinning device, adjust the injection pump rate to 10ml / h; the voltage of the high voltage generator is 22KV, the negative pressure of the receiving device is 5KV, and the electrospinning is started to obtain the functional layer, and the functional layer and the anti-adhesion layer Cross-linking to prepare a cross-linked composite structure with the anti-adhesion layer as the base an...

Embodiment 3

[0037] Carry out rabbit animal experiment with the dura mater patch that embodiment 1, 2 makes

[0038] Select healthy rabbits, artificially create part of the dura mater defect under general anesthesia, then implant the dura mater patch for repair, suture and fix. After the operation, the animals were fed routinely and observed regularly. Six months after the operation, tissue samples were extracted according to standard requirements, and case slides were prepared. The material was obviously degraded, with a very small amount of residue, increased collagen fibers, and slight cystic wall formation at the interface; 12 months after the operation, the tissue specimen was cut, no material residue, the dura mater healed well, only traces of sutures were seen, the brain tissue was normal, and there was no abnormality reaction.

[0039] The anti-adhesion composite dura mater patch and the preparation method thereof of the present invention, the layer facing the brain is designed a...

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Abstract

The invention relates to an anti-adhesion compound dural patch and a preparation method thereof. The anti-adhesion compound dural patch comprises an anti-adhesion layer and a functional layer, wherein the anti-adhesion layer is a layer of dense membrane facing the brain; the functional layer is a layer of nanofiber membrane back to the brain; the anti-adhesion layer and the functional layer are compounded in a cross-linking mode. The invention further provides a preparation method. The preparation method comprises the steps that a layer facing the brain is designed in the dense membrane, the surface is smooth and the anti-adhesion is more effective compared with other spinning or prepared products, thus cerebrospinal fluid is effectively prevented from leaking; a layer back to the brain is a nanofiber functional layer which is beneficial for the cell attachment, promotes the cell growth, and accelerates the dural repair; and the dense membrane and the nanofiber functional layer are compounded in a cross-linking mode, wherein the anti-adhesion effect is better, the leakage problem is more avoided, and the practical value is good.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to an anti-adhesion composite dura mater patch and a preparation method thereof. Background technique [0002] Dural defect is one of the common diseases in neurosurgery, mostly caused by trauma, tumor, cerebrovascular disease, and other neurological diseases that require craniotomy. Dural defects need to be repaired in time to prevent cerebrospinal fluid leakage and external pressure, otherwise it will cause complications such as intracranial infection, brain adhesion, subcutaneous effusion, etc., which will endanger human life in severe cases. [0003] At present, there are two main types of dura mater repair materials: non-absorbable materials and absorbable materials. Non-absorbable materials will permanently remain in the body after implantation. As a foreign body, it will cause local tissue inflammation and infection after insertion. Absorbable materials will be absorbed by ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/00A61F2/02
CPCA61F2/0063A61F2/02A61F2210/0076
Inventor 刘超万隆
Owner SHANGHAI DIVINE MEDICAL TECH
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