Silicon dioxide nanofiber membrane, and preparation method and application thereof

A technology of nanofiber membrane and silica, which is applied in fiber treatment, DNA preparation, spinning solution preparation, etc. It can solve the problems of small specific surface area of ​​silica gel membrane, unfavorable large-scale production, complex process conditions, etc., and achieve surface energy and The effect of high surface activity, small thickness and simple preparation method

Inactive Publication Date: 2017-07-11
MATERIAL & IND TECH RES INST BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Although the prior art uses electrospinning technology to prepare a silica gel membrane for adsorbing RNA, it needs to add a directing agent, and high temperature reaction is required to form a silicon source, followed by calcination, modification, etc., and the process conditions are relatively complicated. The obtained silica gel membrane has a small specific surface area, and then the filtration efficiency is low, and the preparation cost is high, which is not conducive to large-scale production

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  • Silicon dioxide nanofiber membrane, and preparation method and application thereof
  • Silicon dioxide nanofiber membrane, and preparation method and application thereof
  • Silicon dioxide nanofiber membrane, and preparation method and application thereof

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Embodiment approach

[0031] According to a preferred embodiment of the present invention, the density of the silica nanofiber membrane is 1-4kg / m 3 , preferably 1.2-2kg / m 3 .

[0032] In the present invention, the density of the silica nanofiber membrane refers to the measured mass per unit volume at room temperature.

[0033] According to a preferred embodiment of the present invention, the thickness of the silica nanofiber membrane is 25-55 μm, preferably 30-50 μm.

[0034] In the present invention, the thickness of the silica nanofiber film is measured by a spiral micrometer.

[0035] According to a preferred embodiment of the present invention, the silica nanofiber membrane is prepared by electrospinning technology using nano-silicon dioxide as a silicon source.

[0036] According to a preferred embodiment of the present invention, the average particle diameter of the nano silicon dioxide is 20-120 nm, preferably 20-50 nm. Adopting this preferred average particle diameter can make the fibe...

Embodiment 1

[0073] (1) Weigh 5g of silica nanospheres (with an average particle size of 40nm) and dissolve them in 35g of N,N-dimethylformamide, then add 0.8g of polyethylene glycol 400 (Sinopharm) dropwise, stir and use Ultrasonic the cell disruptor for 2 hours, put it into a grinding disperser, grind and disperse for 8 hours to obtain a nano-silica dispersion, and the SEM image of the nano-silica dispersion is as follows figure 1 As shown, it can be seen from the figure that the nano-silica dispersion is evenly dispersed;

[0074] (2) Weigh 10g of polyacrylonitrile (Bailingwei Technology Co., Ltd.) and dissolve it in 49.2g of N,N-dimethylformamide, and stir it ultrasonically to obtain a polymer solution;

[0075] (3) Pour the nano silicon dioxide dispersion described in step (1) into the polymer solution described in step (2), and stir to obtain a spinning solution, the viscosity of which is 1400cP;

[0076] (4) Utilize electrospinning technology to process the spinning solution descri...

Embodiment 2

[0086] (1) Weigh 3g of silica nanowires (average particle size 20nm) and dissolve them in 20g of dimethyl sulfoxide, then add 0.5g of carboxymethyl cellulose (C104984, Aladdin) dropwise, stir and use cell breaker Ultrasonic instrument for 2 hours, put into a grinding disperser to grind and disperse for 8 hours to obtain a nano-silica dispersion;

[0087] (2) Weigh 7g of polylactic acid (2003D, Nature Works, USA) and dissolve it in 69.5g of N,N-dimethylformamide, and stir it ultrasonically to obtain a polymer solution;

[0088] (3) Pour the nano silicon dioxide dispersion liquid described in step (1) into the polymer solution described in step (2), and stir to obtain a spinning solution, the viscosity of the spinning solution is 800cP;

[0089] (4) Utilize electrospinning technology to process the spinning solution described in step (3), extract 15ml spinning solution with a disposable syringe (diameter 2cm), the implementation parameters of electrospinning technology include: ...

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Abstract

The invention relates to the field of nanometer materials, and discloses a silicon dioxide nanofiber membrane, and a preparation method and application thereof. The method comprises the following steps: (1) preparing spinning solution containing nanosilicon dioxide, a surface active agent, a high-molecular polymer and solvent, and (2) processing the spinning solution prepared in step (1) by utilizing electrospinning technique, and drying to obtain the silicon dioxide nanofiber membrane, wherein the average grain diameter of the nanosilicon dioxide in step (1) ranges from 20nm to 120nm. The fiber diameters of the silicon dioxide nanofiber membrane which is prepared by the method provided by the invention range from 80nm to 600nm; the thickness is small; therefore, the bore diameter and specific surface area of the silicon dioxide nanofiber membrane are relatively large; the surface energy and surface activity are high; the silicon dioxide nanofiber membrane provided by the invention can be applied into an RNA (ribose nucleic acid) extraction kit adsorbing column, and has the advantages that the extraction scope and category are wide, the extraction is rapid, simple and convenient, the purification rate is high, and the ratio of performance to price is high.

Description

technical field [0001] The present invention relates to the field of nanomaterials, in particular to a silica nanofiber membrane, a method for preparing a silica nanofiber membrane, and the silica nanofiber membrane and silica nanofiber prepared by the method Application of membranes in RNA adsorption. Background technique [0002] At present, silica gel is the most widely used polar adsorbent. It has a porous network structure. Its main advantage is that it is chemically inert and has a large adsorption capacity. It is easy to prepare porous materials of different types, different pore sizes, and different surface areas. non-toxic silicone. The main methods of traditional RNA extraction are to use similar compatibility principle to extract or use chemical reagents to extract nucleic acid (boiling lysis method, phenol-chloroform method). These two methods are likely to cause environmental pollution due to the large use of organic solvents, such as phenol and chloroform. T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/728D01D1/02D01D5/00C12N15/10
CPCC12N15/1003D01D1/02D01D5/0015D04H1/728
Inventor 程雪于卫昆赵秀婷
Owner MATERIAL & IND TECH RES INST BEIJING
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