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Medical adhesive containing catechol polymer and preparation method thereof

A technology of catechol and polymers, which is applied in the field of medical adhesives containing catechol polymers and its preparation, can solve the problems of low biotoxicity and low degradation rate, and achieve good adhesion tissue effect and low degradation rate. Moderate, simple synthesis and preparation process

Inactive Publication Date: 2017-07-18
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to overcome the defects and insufficiencies of the prior art adhesives for traditional Chinese medicine, improve the catechol-containing polymer synthesized in the previous stage, and then prepare a kind of adhesive tissue with good effect and strong bond strength. A medical adhesive that can be adjusted, has low biotoxicity, has a good degradation rate, and can effectively promote wound healing

Method used

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  • Medical adhesive containing catechol polymer and preparation method thereof
  • Medical adhesive containing catechol polymer and preparation method thereof
  • Medical adhesive containing catechol polymer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] 1. Preparation:

[0051](1) Weigh 1.0 g of dopamine-N,N'-methylenebisacrylamide, 1.2 g of propane sultone, and 0.2 g of sodium bromide in 10 mL of N,N-dimethylformamide (o-phenyl The molar ratio of diphenol repeating units to cyclic monomers was 1:3), sonicated for 20 min to obtain a clear solution, and reacted at 45 °C for 20 h. After the reaction is completed, the resulting mixed system is concentrated by vacuum distillation, and then precipitated twice in tetrahydrofuran to remove unreacted propane sultone, dissolved with N,N-dimethylformamide and transferred to a dialysis bag Dialyzed at 4°C for 2 days, freeze-dried to obtain an improved catechol-containing polymer, whose structural formula is as follows:

[0052]

[0053] (2) Weigh 17 mg of the obtained improved catechol-containing polymer (catechol unit concentration is 2.6 mol / L) and dissolve it in 20 μL dimethyl sulfoxide, sonicate for 20 min, add 1% catechol 500 nm silicon dioxide particles, ultrasonic 10 ...

Embodiment 2

[0058] 1. Preparation

[0059] (1) Weigh 1.0 g of 6-hydroxydopamine-1,6-hexanediol diacrylate copolymer, 0.6 g of styrene oxide, and 0.1 g of lithium bromide in 10 mL of N,N-dimethylacetamide (o-phenyl The molar ratio of diphenol repeating units to cyclic monomers was 1:2), sonicated for 20 min to obtain a clear solution, and reacted at 45 °C for 35 h. After the reaction was completed, the resulting mixed system was concentrated by distillation under reduced pressure, and then precipitated in ethanol twice to remove unreacted lithium bromide. The precipitate was dissolved with N,N-dimethylacetamide and transferred to a dialysis bag for dialysis at 4 °C for 2 days, freeze-dried to obtain an improved catechol-containing polymer, and its structural formula is as follows:

[0060]

[0061] (2) Weigh 21 mg of the obtained improved catechol-containing polymer (catechol unit concentration is 2.6 mol / L) and dissolve it in 20 μL N,N-dimethylacetamide, sonicate for 20 min, add mass ...

Embodiment 3

[0066] 1. Preparation

[0067] (1) Weigh 1.0 g 1-(3,4-dihydroxyphenyl)-2-aminoethanol-N,N'-bis(acryloyl)cystamine copolymer, 0.2 g epichlorohydrin, 0.5 mL Hydrochloric acid was dissolved in 10 mL of N,N-dimethylformamide / water 1:1 mixed solvent (the molar ratio of catechol repeating unit to cyclic monomer was 1:1), and a clear solution was obtained by ultrasonication for 20 min. React at 45 °C for 15 h. After the reaction was completed, the resulting mixed system was concentrated by vacuum distillation, and the precipitate was dissolved with N,N-dimethylformamide, then transferred to a dialysis bag for dialysis at 4 °C for 2 days, and then freeze-dried to obtain an improved catechol-containing A polymer whose structural formula is as follows:

[0068]

[0069] (2) Weigh 23 mg of the obtained improved catechol-containing polymer (catechol unit concentration is 2.6 mol / L) and dissolve it in 20 μL dimethyl sulfoxide, sonicate for 20 min, add 300 nm silica particles, sonicat...

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Abstract

The invention belongs to the technical field of a biomedical material and discloses a medical adhesive containing catechol polymer. A preparation method comprises the following steps: performing ring-opening reaction on catechol polymer with a tertiary amine group on a main chain, grafting side chains with different structures and different grafting ratios on the main chain of the polymer to acquire modified polymer containing catechol, and then interacting the polymer with the silicon dioxide nano-particle and an oxidizing agent, thereby acquiring the medical adhesive. The medical adhesive prepared according to the invention has better adhesive property, adjustable adhering strength and degradation property, low biotoxicity and capability of effectively promoting wound healing; the synthetic preparation process is simple; the medical adhesive has an excellent application prospect.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a medical adhesive containing a catechol polymer and a preparation method thereof. Background technique [0002] "Medical adhesives" in a broad sense means medical supplies including adhesive plasters, hemostatic agents and surgical adhesives, and in a narrow sense means those directly used in medical fields including dermatology, gastroenterology, vascular surgery and plastic surgery adhesive. Medical adhesives have the advantages of no secondary injury, simple and quick operation, and can effectively prevent the leakage of gas or body fluid, etc., and their clinical applications are becoming more and more extensive. Because the medical adhesive directly contacts the skin, it should be biocompatible, and the adhesive and its degradation products should not be toxic or harmful to the body, that is, biocompatible. In addition, it should exhibit good adhe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G73/02C09J179/02C09J11/04A61L24/00A61L24/06
CPCA61L24/0042A61L24/06C09J11/04C09J179/02C08G73/02C08K3/36
Inventor 陈永明赖欣宜彭勃
Owner SUN YAT SEN UNIV
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