Graphene oxide/manganese tungstate/polyethylene glycol nano-hybrid material and its preparation
A nano-hybrid material, polyethylene glycol technology, applied in wave energy or particle radiation treatment materials, preparation of X-ray contrast agents, preparations for in vivo tests, etc., can solve the problems of difficult CT diagnosis and low sensitivity, etc. To achieve the effects of excellent dispersibility and biocompatibility, simple preparation process and easy availability of raw materials
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Embodiment 1
[0050] GO / MnWO 4 The preparation of the / PEG nanometer multifunctional material includes the following steps.
[0051] (1) Weigh 50mg Mn(NO 3 ) 2 4H 2 Dissolve O in 20mL of triethylene glycol, then disperse 70mg of GO in 20mL of triethylene glycol, stir and mix the above solution and adjust the pH value to 6;
[0052] (2) Weigh 66mg Na 2 WO 4 2H 2 O was dissolved in 5 mL of deionized water, slowly added to the mixed solution in step (1), and after stirring for 30 min, 2 mL of an aqueous solution containing 113 mg of aminocaproic acid was added to the mixed solution in (1) and (2) steps;
[0053] (3) Heat the solution obtained above to 220°C under high-speed stirring. After reacting for 2 hours, add 10 mL of triethylene glycol dissolved with 500 mg of PEG (1500), continue the reaction for 1 hour, and then naturally cool the reaction system to room temperature;
[0054] (4) The reaction solution finally obtained in the above steps was washed three times with ethanol and u...
Embodiment 2
[0060] GO / MnWO prepared in Example 1 4 / PEG nanomaterial aqueous solution was prepared as 0, 25, 50, 75, 100, 150, 200 μg / mL solutions, and the heating performance and photothermal cycle stability of the solutions were tested under 808nm laser irradiation.
[0061] Figure 5 GO / MnWO in this example 4 Visible-near-infrared spectra of materials with different concentrations of / PEG. It can be observed that the absorbance of nanomaterials in the near-infrared increases with the increase of concentration.
[0062] Figure 6 GO / MnWO in this example 4 / PEG different concentration materials at 808nm, 1.2W / cm 2 The temperature rise curve of laser irradiation for 10 minutes, which verifies the GO / MnWO 4 / PEG can produce photothermal effects under near-infrared laser irradiation.
[0063] Figure 7 GO / MnWO in this example 4 / PEG different concentration materials at 808nm, 1.2W / cm 2 In the visible-near-infrared image after 10 minutes of laser irradiation, the visible-near-infrar...
Embodiment 3
[0066] GO / MnWO prepared in Example 1 4 / PEG nanomaterial water was prepared as aqueous solutions with different concentrations, and its MRI imaging properties were obtained under the magnetic field strength of 0.5T.
[0067] Figure 9 For GO / MnWO in Example 3 4 / T of PEG material dispersed in water 1 Weighted imaging image, with the increase of solution concentration, the content of Mn element increases, T 1 The more obvious the weighted imaging effect is, the r of the material 1 The value is 11.34Mm -1 the s -1 r 2 24.06Mm -1 the s -1 ,r 2 / r 1 = 2.12, suitable as T 1 contrast agent. These data also suggest that GO / MnWO 4 / PEG nanomaterials can be used as good T 1 contrast agent.
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