P-oxanone and L-phenylalanine copolymer and application thereof

A technology of phenylalanine and copolymer, which is applied in the field of p-oxycyclohexanone and L-phenylalanine copolymer and its application, and can solve problems such as poor mechanical strength

Active Publication Date: 2017-08-04
川北医学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, the mechanical strength of the film made by single PDPA is very poor due to being limited by its molecular weight; therefore, this single film is still difficult to operate in practical applications. The L-phenylalanine copolymer system is still a difficult problem for those skilled in the art, especially the application in the medicine of the disease caused by cell fibrosis, such as anti-adhesion materials, etc.

Method used

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  • P-oxanone and L-phenylalanine copolymer and application thereof
  • P-oxanone and L-phenylalanine copolymer and application thereof
  • P-oxanone and L-phenylalanine copolymer and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Preparation and Characterization of PDPA Polymer

[0046] Table 1. PDPA series polymers

[0047]

[0048] a GPC method to determine its weight average molecular weight

[0049] Characterization of PDPA polymer

[0050] The L-phenylalanine content of PDPA polymerized by NMR 1 HNMR determination, specifically 1 For HNMR, see literature (J.APPL.POLYM.SCI.2013, DOI: 10.1002 / APP.39455).

[0051] Polymer molecular weight is determined by GPC method (DMF mobile phase), and the results are shown in Table 1.

Embodiment 2

[0053] Preparation method of each implant material

[0054] 1) Preparation method of medicine for preventing and treating scar hyperplasia and abdominal wall fibrosis

[0055] After the PDPA-5 polymer was synthesized, it was dissolved in chloroform, stirred and filtered to remove insoluble matter, and the obtained filtrate was slowly dropped into ether while stirring, and the polymer powder was precipitated, and the residual organic solvent was removed by vacuum drying for 24 hours. The obtained dry polymer powder is the implant drug used.

[0056] 2) Preparation method of composite film for preventing postoperative abdominal adhesion

[0057] Dissolve PDPA and PLGA in hexafluoroisopropanol according to the corresponding mass ratio to prepare a concentrated solution with a concentration of 10% w / v, and perform electrospinning to prepare a porous fiber membrane. The preparation parameters are as follows: injection rate 1mL / h , Voltage 8kv, ambient temperature 30°C, ambient re...

Embodiment 3

[0061] Experiment on the effect of preventing and treating scar hyperplasia in epidermal wounds

[0062] The precondition of the test is to use natural uninfected New Zealand rabbits or SD rats to carry out relevant experimental tests, divide the animals into random groups, 5 animals in each group, and test the experimental groups continuously.

[0063] 1) Circular incision on the inner skin of the rabbit ear 1

[0064] Use a circular drill to make a circular incision on the inner skin of the New Zealand rabbit's auricle to the cartilage layer, remove the cut circular skin, apply Example 1 prepared according to the method in Example 2 to the wound once a day within one week after the operation Polymer PDPA-5 powder / Bactobang ointment (stir the PDPA powder evenly into the Bactobang ointment, the following groups are made in the same way), and the control groups are: Bactobang ointment, L-phenylalanine / Bactobang ointment, D-phenylalanine / Bactobang ointment, no treatment bla...

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Abstract

The invention relates to an application of a p-oxanone and L-phenylalanine copolymer as shown in a structural formula (I) in preparing a drug for treating diseases induced by cell fibrosis, a pharmaceutical composition taking the copolymer as an active ingredient, an application of the compound and the pharmaceutical composition in preparing a drug for treating diseases induced by cell fibrosis, an application in preparing a drug for treating abdominal fibrosis caused by hyperplasia of skin scar tissue and repetitive stimulation, and an application in preparing a material for treating adhesion of postoperative abdominal tissues.

Description

technical field [0001] The invention relates to an L-phenylalanine system copolymer, in particular to a p-oxycyclohexanone-L-phenylalanine copolymer and its application. Background technique [0002] Fibroblasts are the main repair cells for body damage, and their massive proliferation and apoptosis inhibition is one of the biological basis of scar tissue formation. Based on the current understanding of scar tissue formation, fibroblasts are activated in a certain differentiation state due to their own changes, and are not regulated by growth factors to become cancer cell growth models, which is the main cause of scar formation. In addition, a large number of fibroblasts proliferate and secrete a large number of growth factors, collagen, and fibrin, which eventually lead to collagen deposition, which leads to abdominal wall fibrosis and postoperative abdominal adhesions in long-term peritoneal dialysis patients. When the peritoneum is poorly healed, fibroblasts signal the d...

Claims

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Application Information

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IPC IPC(8): A61K31/785A61P17/02A61P17/00A61L31/06A61L31/14A61L31/16
CPCA61K31/785A61L31/06A61L31/14A61L31/16A61L2300/216A61L2300/40C08L77/12
Inventor 王冰陈钏罗乐沈成义朱江牛丽静吴昌强董军冯成敏肖鑫张小明
Owner 川北医学院
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