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A photodynamic therapy system and method for continuously generating singlet oxygen

A technology based on singlet oxygen and lanthanides, applied in photodynamic therapy, phototherapy, treatment, etc., can solve problems such as insufficient singlet oxygen and poor effect of photodynamic therapy systems

Active Publication Date: 2020-08-18
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the above defects or improvement needs of the prior art, the present invention provides a multifunctional lanthanide nanoparticle, a preparation method thereof, a method for generating singlet oxygen by using the nanoparticle and a photodynamic therapy system, the purpose of which is to By constructing the lanthanide nanoparticles, the near-infrared laser is used to excite the lanthanide nanoparticles, combined with a hyperbaric oxygen chamber, to achieve oxygen supply and oxygenation, thereby promoting the targeted delivery of nanoparticle drugs and the generation of singlet oxygen. This solves the technical problems of insufficient singlet oxygen generation and poor photodynamic therapy system effects in the prior art

Method used

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  • A photodynamic therapy system and method for continuously generating singlet oxygen
  • A photodynamic therapy system and method for continuously generating singlet oxygen
  • A photodynamic therapy system and method for continuously generating singlet oxygen

Examples

Experimental program
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preparation example Construction

[0058] The preparation method of the above-mentioned lanthanide nanoparticles, comprising the steps of:

[0059] 1) Add oleic acid and octadecene to the mixture of gadolinium acetate, yttrium acetate, erbium acetate and calcium acetate, heat up to 130-160°C under an inert gas environment, and stir for 45-60 minutes to obtain solution A;

[0060] 2) Cooling the solution A to 20-30° C., adding a methanol solution of sodium hydroxide / ammonium fluoride dropwise to the solution A to obtain a solution B;

[0061] 3) Heating the solution B to 50-70°C, vacuuming to remove methanol, raising the temperature to 260-320°C at 5-20°C / min in an inert gas environment, and reacting for 30-50min to obtain oil-soluble NaGd (1-x-y-z) f 4 :Yb x , Er y , Ca z nanoparticle mixture;

[0062] 4) the oil-soluble NaGd (1-x-y-z) f 4 :Yb x , Er y , Ca z Cool the nanoparticle mixture to 20-30°C, add 2-4 times the volume of ethanol, and centrifuge to obtain oil-soluble NaGd (1-x-y-z) f 4 :Yb x ...

Embodiment 1

[0088] Preparation of NaGd 0.7 f 4 :Yb 0.18 , Er 0.02, Ca 0.1 @NaYb 0.9 f 4 : Ca 0.1 @NaNd 0.6 f 4 :Gd 0.3 , Ca 0.1 @mSiO 2 -Rose Bengal

[0089] 1.1 Preparation of NaGd 0.7 f 4 :Yb 0.18 , Er 0.02 , Ca 0.1

[0090] 1) Weigh 0.7mmol of gadolinium acetate, 0.18mmol of yttrium acetate, 0.02mmol of erbium acetate, and 0.1mmol of calcium acetate, add 4ml of oleic acid and 7ml of octadecene, heat up to 140°C under an argon atmosphere, and stir for 1h to obtain Solution A;

[0091] 2) Cool solution A to room temperature, add 10 ml of methanol solution containing 4 mmol sodium hydroxide / ammonium fluoride dropwise to solution A with a peristaltic pump, control the speed of the peristaltic pump, and adjust the dropping rate to 0.3 ml / min to obtain solution B ;

[0092] 3) Solution B was heated to 60°C, vacuumed to remove methanol, heated to 280°C at 10°C / min under argon atmosphere, and reacted for 60 minutes to obtain oil-soluble NaGd 0.7 f 4 :Yb 0.18 , Er 0.02 ,...

Embodiment 2

[0116] NaGd 0.73 f 4 :Yb 0.2 ,E r0.02 , Ca 0.05 @NaYb 0.95 f 4 : Ca 0.05 @NaNd 0.65 f 4 :Gd 0.3 , Ca 0.05 @mSiO 2 or

[0117] NaGd 0.7 f 4 :Yb 0.2 ,E r0.05 , Ca 0.05 @NaYb 0.95 f 4 : Ca 0.05 @NaNd 0.65 f 4 :Gd 0.3 , Ca 0.05 @mSiO 2 It can also be prepared according to a method similar to Example 1. The particle size of the oil-soluble nanoparticles of the present invention is regulated by adjusting the reaction temperature and time. The higher the temperature and the longer the reaction time, the larger the particle size of the oil-soluble nanoparticles .

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Abstract

The invention discloses a multifunctional lanthanide nanoparticle, a preparation method thereof, a method for generating singlet oxygen by using the nanoparticle and a photodynamic therapy system. The lanthanide is excited by a near-infrared laser in combination with a hyperbaric oxygen chamber. Nanoparticles can realize oxygen supply sensitization, thereby promoting the targeted delivery of nanoparticle drugs and the generation of singlet oxygen, thereby solving the technical problems of insufficient generation of singlet oxygen and poor effect of photodynamic therapy systems in the prior art.

Description

technical field [0001] The invention belongs to the field of medical equipment, and more specifically relates to a photodynamic therapy system. Background technique [0002] Photodynamic therapy is a non-invasive treatment method, which has been widely used in the treatment of clinical superficial tumors. It has the advantages of high selectivity, less toxic side effects, and less trauma. However, the wavelengths absorbed by photosensitizers are mostly ultraviolet or visible light, and the tissue penetration depth of light in this band is shallow; secondly, photosensitizers rely on oxygen to generate oxygen free radicals, and the microenvironment of hypoxia in tumor tissues leads to low production rates. Therefore, improving the penetration depth of light in the tissue, alleviating the hypoxia at the tumor site, and increasing the single-line oxygen production rate are difficult problems to be overcome in clinical photodynamic therapy. [0003] The penetration depth of ligh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/04A61K41/00A61K9/14A61K47/02A61P35/00A61N5/067A61G10/02
CPCA61G10/026A61K9/143A61K41/0057A61K41/0071A61N5/062A61N2005/0659A61N5/067
Inventor 杨祥良张燕李静秋
Owner HUAZHONG UNIV OF SCI & TECH
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