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Preparation method of bone scaffold composite material

A technology of composite materials and bone scaffolds, applied in the field of preparation of bone scaffold composite materials, can solve the problems of high price, economic loss of patients, tissue necrosis, etc., and achieve cost reduction, strong comprehensive bone repair ability, and good biocompatibility Effect

Active Publication Date: 2017-09-15
NORTHWEST UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Take Bio-Oss bone powder in Switzerland as an example. Although it has an absolute dominant position in the market, it has the following disadvantages: (1) It is expensive, which not only hinders the popularization of bone implant surgery, but also brings economic losses to patients ; (2) Powdered osteogenic materials have poor osteogenic performance and can easily lead to tissue necrosis; (3) There is only a calcined deimmunization process without surface modification and lack of bone growth promotion
The sale of a brand of Shanxi "Gurui" is not only difficult to shake the dominance of imported materials, but also, like "Bio-oss", has not undergone surface modification treatment, and still lacks the effect of promoting bone growth

Method used

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  • Preparation method of bone scaffold composite material
  • Preparation method of bone scaffold composite material
  • Preparation method of bone scaffold composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Calcination of natural bovine cancellous bone by ammonium dihydrogen phosphate method:

[0045] 1.2 Calcination of adult bovine cancellous bone and fetal bovine cancellous bone:

[0046] 1.2.1 Bone preparation and organic matter removal

[0047] Saw off the metaphysis of fresh fetal bovine femur from the femur with a small saw, change the liquid several times with 0.5M / L sodium hydroxide solution under normal pressure, boil to remove grease, and then saw into 10×5×5 (mm 3 ) large and small bone fragments; soak in 0.3M sodium hydroxide solution for 48 hours, and soak in 10% hydrogen peroxide solution for 12 hours.

[0048] 1.2.2 Calcination by sodium pyrophosphate method and ammonium dihydrogen phosphate method

[0049] Step 1: After the filter paper absorbs most of the water, dry it at 80°C for 12 hours; put the dried bone into a muffle furnace for calcination, raise the temperature slowly (5°C / min), maintain it at 800°C for 6 hours, and then follow the furnace Cooli...

Embodiment 2

[0063] The relationship between the microstructure and biomechanical properties of bone scaffold materials and bone defect repair:

[0064] After implanted in the body, the bone scaffold material will fully contact with tissues, cells, etc., provide them with growth space, and provide good transporters for metabolites, inflammatory factors, cytokines, etc. during the growth process. Therefore, in addition to the chemical properties of the bone scaffold material itself, the microstructure and mechanical properties of the bone scaffold material are also one of the important factors affecting its osteogenesis. The microstructure such as pore size, porosity and pore distribution and the Young's modulus of the material not only provide the necessary environment for cell adhesion, differentiation and proliferation, but also can significantly affect the response of cells and the degradation of materials during bone repair.

[0065]The pore size of the porous scaffold material is of g...

Embodiment 3

[0125] Preparation of zinc + chitosan surface-modified bone scaffold material and detection of biocompatibility and osteogenesis ability:

[0126] 1.1 Preparation of fetal bovine bone + zinc + chitosan composite material:

[0127] The preparation method of fetal bovine bone is the same as 1.2.1 and 1.2.2 in Example 1. Prepare 500ml of 0.25M ZnCl solution. Use negative pressure suction to fully combine the ZnCl solution with the calcined bone, 60 ° C water bath for 1 hour, and then prepare by low-temperature calcination; prepare 20ml chitosan acetic acid solution (10g / L) and use negative pressure suction to make the chitosan acetic acid solution Full access to Zn-containing 2+ Fetal bovine bone calcined bone, kept at 4°C for 24h; its Zn 2+ The specific detection methods of content and calcium-phosphorus ratio, pore size, surface microstructure observation, porosity detection, compressive strength and Young's modulus are the same as the corresponding methods in the first and ...

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Abstract

The invention discloses a preparation method of a bone scaffold composite material. The preparation method comprises the following steps: 1) preparing a [beta]-TCP ([beta]-tertiary calcium phosphate) calcined bone block; 2) preparing a [beta]-TCP / Zn2+ calcined bone block; 3) preparing a [beta]-TCP / CS composite scaffold material; and 4) preparing the [beta]-TCP / Zn2+ / CS porous composite scaffold material. The preparation method of the bone scaffold composite material provided by the invention has the beneficial effects that fetal bovine cancellous bone (the [beta]-tertiary calcium phosphate), which undergoes secondary calcining by virtue of an ammonium dihydrogen phosphate method and accepts double surface modification, namely adding zinc and adding chitosan, is a bone scaffold material which is good in biocompatibility and comprehensive bone repair capacity; meanwhile, along with large-area popularization of serum therapy, fetal calf serum plants in China achieve large-scale development, dosage of fetal calf serum is gradually increased while natural bovine cancellous bone, as a surplus material of producing the fetal calf serum, is wasted off; and with the full use of the bovine cancellous bone, costs of two medical industries can be reduced.

Description

technical field [0001] The invention relates to the technical field of medical material preparation, in particular to a method for preparing a bone scaffold composite material. Background technique [0002] Jaw defect can lead to the loss of the function of the oral and jaw system, which has a huge impact on people's life and work. Implanting bone scaffold materials to achieve bone defect repair is an effective treatment approach. In recent years, with the increase of trauma, tumors and other diseases, coupled with the approach of aging society, the incidence of jaw defects in the population is gradually increasing, and the demand for bone scaffold materials is also increasing. At present, the powder-type imported material occupies an absolute dominant position in the jaw bone scaffold material market in my country. This material is expensive and cannot be used for repairing bone defects with large wounds (above 8mm), and lacks osteogenesis due to lack of surface modificatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/12A61L27/30A61L27/34A61L27/50A61L27/56
CPCA61L27/12A61L27/306A61L27/34A61L27/3608A61L27/3687A61L27/3691A61L27/50A61L27/56A61L2400/18A61L2420/04A61L2430/02A61L2430/40C08L5/08
Inventor 周建业焦康礼张轩宋天柱张菊梅郑欣胡晓潘李志强
Owner NORTHWEST UNIVERSITY FOR NATIONALITIES
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