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A kind of preparation method of iron dextran

A technology of iron dextran and dextran, which is applied in the field of preparation of iron dextran, can solve the problems of uneven molecular weight distribution of dextran raw materials, low iron content of dextran iron, serious environmental pollution, etc., and achieve easy control of process conditions, fewer procedures, and lower ion content Effect

Active Publication Date: 2021-01-15
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The traditional oxidation method is potassium cyanide, but it is more toxic
Later, a patent proposed alkalization, that is, the use of concentrated alkali for activation, but the amount of alkali used is relatively large, and at the same time it is neutralized with acid, which also causes acid pollution.
[0005] At present, many processes have problems such as difficult production, high toxicity, and serious environmental pollution, and the obtained iron dextran has the disadvantages of low iron content, poor solubility, and poor stability.
And the dextran raw material obtained by acid hydrolysis and fermentation has the disadvantages of uneven molecular weight distribution and complicated process

Method used

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  • A kind of preparation method of iron dextran

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Effect test

Embodiment 1

[0028] The preparation method of iron dextran in the present embodiment is as follows:

[0029] 1. Using sucrose as a substrate, synthesize high molecular weight dextran in the presence of dextran sucrase, and then add dextranase to degrade high molecular weight dextran to obtain dextran with a molecular weight of 5000-7500Da; the concentration of sucrose in the reaction system is 300mg / mL, and the dextran The concentration of invertase is 3.0U / mL, the concentration of dextranase is 3.0U / mL, the reaction temperature is 35°C, and the reaction time is 250-300min;

[0030] 2. Add 24g of low-molecular-weight dextran obtained in step 1 into a three-neck flask, add 60ml of pure water, dissolve, raise the temperature to 35°C, adjust the pH value to 5-12 with 20% (w / w) NaOH solution, and then drop Add 36ml of sodium hypochlorite mixed solution (active chlorine content is 5%) and maintain the pH value at 5-12 during the dropwise addition of sodium hypochlorite mixed solution, and perfo...

Embodiment 2

[0034] The preparation method of iron dextran in the present embodiment is as follows:

[0035] 1. Using sucrose as a substrate, synthesize high molecular weight dextran in the presence of dextran sucrase, and then add dextranase to degrade high molecular weight dextran to obtain dextran with a molecular weight of 5000-7500Da; the concentration of sucrose in the reaction system is 300mg / mL, and the dextran The concentration of sucrase is 3.0 U / mL, the concentration of dextranase is 3.0 U / mL, the reaction temperature is 35° C., and the reaction time is 250-300 min.

[0036] 2. Add 24g of low-molecular-weight dextran obtained in step 1 into a three-neck flask, add 70ml of pure water, dissolve, raise the temperature to 45°C, adjust the pH value to 5-12 with 20% (w / w) NaOH solution, and then drop Add 26ml of sodium hypochlorite mixed solution (active chlorine content is 5%) and maintain the pH value at 5-12 during the dropwise addition of sodium hypochlorite, and oxidize at 45°C f...

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Abstract

The invention discloses a preparation method of iron-dextrin. The preparation method comprises the following steps: preparing low molecular weight dextran through bi-enzyme (dextransucrase-dextranase) synergy, and then oxidizing dextran by taking sodium hypochlorite mixed liquor as an oxidizing agent, so as to obtain an oxidation-type dextran; simultaneously titrating and complexing with weak base and acid-base to prepare iron-dextrin and curing iron-dextrin under the conditions of high temperature and high pH value, so as to obtain cured iron-dextrin; filtering unreacted dextran and micromolecule iron-dextrin and ions therein with biological membranes with different molecular weights, so as to obtain purified iron-dextrin. The iron-dextrin prepared by the invention is uniform in distribution of the molecular weight, high in stability and less in content of impurities. Various indexes of iron-dextrin synthesized by the method conform to the requirements of Chinese pharmacopoeia, and the solubility of iron-dextrin is very good.

Description

technical field [0001] The invention relates to a preparation method of iron dextran iron supplement for iron deficiency anemia. Background technique [0002] Iron deficiency anemia is the most common type of anemia. Iron deficiency anemia can be caused by insufficient iron intake, iron absorption disorder, and excessive iron loss when the amount of iron increases, and patients may have fatigue, fatigue, dizziness, growth retardation in children, and mental retardation. , economically underdeveloped areas and infants, women of childbearing age significantly increased. Iron dextran can also be used as a drug for preventing and treating iron deficiency anemia in piglets. [0003] Iron dextran, also known as iron dextran, is a complex of dextran with a weight average molecular weight (Mw) of 5000-7500Da and ferric hydroxide, with an iron content of not less than 25%. The appearance of this product is brown to black amorphous or crystalline powder, odorless, astringent, hygro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P19/08C08B37/02
CPCC08B37/0021C12P19/08
Inventor 张洪斌陈爽花敬涵胡雪芹
Owner HEFEI UNIV OF TECH
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