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Azithromycin tablet and preparation method thereof

A technology of azithromycin tablets, azithromycin, applied in the field of medicine to achieve the effect of good quality, good compressibility and high reliability

Active Publication Date: 2017-10-24
YANGTZE RIVER PHARM GRP SICHUAN HAIRONG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, the dissolution behavior, content uniformity, and related substances of azithromycin tablets currently on the market need to be further improved.

Method used

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  • Azithromycin tablet and preparation method thereof
  • Azithromycin tablet and preparation method thereof
  • Azithromycin tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation of embodiment 1 azithromycin sheet of the present invention

[0031] 1. Raw and auxiliary materials: 250g of azithromycin, 30g of lactose, 100g of anhydrous calcium hydrogen phosphate, 4.59 parts of hypromellose, 4g of sodium lauryl sulfate, 26g of croscarmellose sodium, 4g of silicon dioxide, hard Magnesium fatty acid 1g, Opadry coating powder 40g

[0032] 2. Preparation method:

[0033] 1) Weigh 250g of azithromycin, 30g of lactose, 100g of anhydrous calcium hydrogen phosphate and mix well;

[0034] 2) E30 hypromellose was prepared into a solution with a mass fraction of 4.59%, and 100ml was added to make granules;

[0035] 3) drying at 60°C;

[0036] 4) passing the obtained dry granules through a 20-mesh sieve, and sizing;

[0037] 5) Add 4 g of sodium lauryl sulfate, 26 g of croscarmellose sodium, 4 g of silicon dioxide and 1 g of magnesium stearate through a 100-mesh sieve according to weight, and mix evenly again;

[0038] 6) tablet forming to...

Embodiment 2

[0041] The preparation of embodiment 2 azithromycin tablets of the present invention

[0042] 1. Raw materials: 250g of azithromycin, 35g of lactose, 80g of anhydrous calcium hydrogen phosphate, 3g of hypromellose, 3g of sodium lauryl sulfate, 20g of croscarmellose sodium, 3g of silicon dioxide, stearin Magnesium acid 1g, Opadry coating powder 40g.

[0043] 2. Preparation method:

[0044] 1) Weigh 250g of azithromycin, 35g of lactose, and 80g of anhydrous calcium hydrogen phosphate and mix well;

[0045] 2) Prepare E30 hypromellose into a solution with a mass fraction of 3%, take 100ml and add it to make granules;

[0046] 3) drying at 60°C;

[0047] 4) passing the obtained dry granules through a 20-mesh sieve, and sizing;

[0048] 5) Add 3 g of sodium lauryl sulfate, 20 g of croscarmellose sodium, 3 g of silicon dioxide and 1 g of magnesium stearate passed through a 100-mesh sieve according to weight, and mix evenly again;

[0049] 6) tablet forming to obtain azithromyci...

Embodiment 3

[0052] The preparation of embodiment 3 azithromycin tablets of the present invention

[0053] 1. Raw materials: Azithromycin 250g, lactose 40g, anhydrous calcium hydrogen phosphate 100g, hypromellose 8g, sodium lauryl sulfate 8g, croscarmellose sodium 40g, silicon dioxide 8g, stearin Magnesium acid 1g, Opadry coating powder 40g.

[0054] 2. Preparation method:

[0055] 1) Weigh 250g of azithromycin, 40g of lactose, 100g of anhydrous calcium hydrogen phosphate and mix well;

[0056] 2) Prepare E30 hypromellose into a solution with a mass fraction of 8%, and add 100ml to make granules;

[0057] 3) drying at 60°C;

[0058] 4) passing the obtained dry granules through a 20-mesh sieve, and sizing;

[0059] 5) Add 8 g of sodium lauryl sulfate, 40 g of croscarmellose sodium, 8 g of silicon dioxide and 1 g of magnesium stearate through a 100-mesh sieve according to weight, and mix again;

[0060] 6) tablet forming to obtain azithromycin tablets;

[0061] 7) Weigh 40g of white Opad...

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Abstract

The invention discloses an azithromycin tablet. The azithromycin tablet is prepared by taking azithromycin as an active ingredient and adding a filling agent, an adhesive, a disintegrating agent, a surfactant, a flow aid, a lubricating agent and a water-soluble polymer. The azithromycin tablet disclosed by the invention has the advantages of high quality, simple and convenient preparation technology and wide application prospect.

Description

technical field [0001] The invention relates to an azithromycin tablet and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Azithromycin (AM) is a 15-membered macrolide antibiotic. With the following characteristics: [0003] AM achieves antibacterial effect by inhibiting protein synthesis of ribosomal 50s subunit. It has antibacterial activity against a variety of aerobic and anaerobic Gram-positive bacteria and can inhibit many important aerobic and anaerobic Gram-negative bacteria. It is active against common pathogenic bacteria Chlamydia trachomatis and urea-dissolving urea bacteria isolated from the genitourinary system, and also has antibacterial activity against atypical respiratory pathogens Chlamydia pneumoniae and Mycoplasma pneumoniae. The sensitivity of clinically isolated Campylobacter jejuni to AM was higher than that of erythromycin and clarithromycin. Clinical isolates of Helicobacter pylori are very sensitiv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/36A61K31/7052A61K47/38A61P31/04A61P17/00A61P11/00A61P15/00A61P19/04
CPCA61K9/2009A61K9/2013A61K9/2018A61K9/2054A61K9/2095A61K9/2866A61K31/7052
Inventor 吴金伟李元波谢义鹏颜欢刘璇蒋小兵邹笑一蓝海
Owner YANGTZE RIVER PHARM GRP SICHUAN HAIRONG PHARM CO LTD
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